GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	49779990	135837	None	0	Human	Functional	pEC50	=	10.2	10.2	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1	nan
	CHEMBL3730217	135837	None	0	Human	Functional	pEC50	=	10.2	10.2	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1	nan
	67496162	135601	None	0	Human	Functional	pEC50	=	10	10.0	457	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	4.2	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728769	135601	None	0	Human	Functional	pEC50	=	10	10.0	457	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	4.2	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495697	135638	None	0	Human	Functional	pEC50	=	9.9	9.9	8912	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	5	3	3	3.9	NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3729012	135638	None	0	Human	Functional	pEC50	=	9.9	9.9	8912	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	5	3	3	3.9	NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67495547	135399	None	0	Human	Functional	pEC50	=	9.8	9.8	3630	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	8	3	3	3.5	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727613	135399	None	0	Human	Functional	pEC50	=	9.8	9.8	3630	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	8	3	3	3.5	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496555	135629	None	0	Human	Functional	pEC50	=	9.7	9.7	9999	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	4	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	CHEMBL3728932	135629	None	0	Human	Functional	pEC50	=	9.7	9.7	9999	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	4	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	67495917	135672	None	0	Human	Functional	pEC50	=	9.6	9.6	21877	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	5	2	2	4.0	CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729214	135672	None	0	Human	Functional	pEC50	=	9.6	9.6	21877	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	5	2	2	4.0	CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	124093849	183182	None	0	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	330	4	2	3	3.1	COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113194
	CHEMBL4794375	183182	None	0	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	330	4	2	3	3.1	COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113194
	127024365	135809	None	0	Human	Functional	pEC50	=	9.5	9.5	575	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1	nan
	CHEMBL3730056	135809	None	0	Human	Functional	pEC50	=	9.5	9.5	575	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1	nan
	67496467	135873	None	0	Human	Functional	pEC50	=	9.5	9.5	3388	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	3.1	NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730438	135873	None	0	Human	Functional	pEC50	=	9.5	9.5	3388	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	3.1	NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	127024366	135824	None	0	Human	Functional	pEC50	=	9.5	9.5	676	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1	nan
	CHEMBL3730133	135824	None	0	Human	Functional	pEC50	=	9.5	9.5	676	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1	nan
	67495052	136082	None	0	Human	Functional	pEC50	=	9.5	9.5	43	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	8	2	3	4.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731671	136082	None	0	Human	Functional	pEC50	=	9.5	9.5	43	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	8	2	3	4.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495909	135706	None	0	Human	Functional	pEC50	=	9.4	9.4	501	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	8	2	3	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1	nan
	CHEMBL3729434	135706	None	0	Human	Functional	pEC50	=	9.4	9.4	501	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	8	2	3	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1	nan
	67495424	136248	None	0	Human	Functional	pEC50	=	9.4	9.4	3090	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	2	3	2.9	CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732621	136248	None	0	Human	Functional	pEC50	=	9.4	9.4	3090	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	2	3	2.9	CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422323	135988	None	0	Human	Functional	pEC50	=	9.4	9.4	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	8	3	5	3.1	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3731107	135988	None	0	Human	Functional	pEC50	=	9.4	9.4	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	8	3	5	3.1	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	87422349	136019	None	0	Human	Functional	pEC50	=	9.4	9.4	758	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1	nan
	CHEMBL3731259	136019	None	0	Human	Functional	pEC50	=	9.4	9.4	758	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1	nan
	67496515	135946	None	0	Human	Functional	pEC50	=	9.3	9.3	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	433	6	3	3	2.4	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3730874	135946	None	0	Human	Functional	pEC50	=	9.3	9.3	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	433	6	3	3	2.4	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	87422373	135398	None	0	Human	Functional	pEC50	=	9.3	9.3	2570	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	7	3	5	2.8	NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3727601	135398	None	0	Human	Functional	pEC50	=	9.3	9.3	2570	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	7	3	5	2.8	NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	67496242	135584	None	0	Human	Functional	pEC50	=	9.3	9.3	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	8	2	4	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1	nan
	CHEMBL3728644	135584	None	0	Human	Functional	pEC50	=	9.3	9.3	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	8	2	4	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1	nan
	67495587	135999	None	0	Human	Functional	pEC50	=	9.3	9.3	758	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	3	4.0	NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	CHEMBL3731166	135999	None	0	Human	Functional	pEC50	=	9.3	9.3	758	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	3	4.0	NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	87422150	135511	None	0	Human	Functional	pEC50	=	9.2	9.2	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	8	3	5	2.9	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728245	135511	None	0	Human	Functional	pEC50	=	9.2	9.2	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	8	3	5	2.9	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495044	135708	None	0	Human	Functional	pEC50	=	9.2	9.2	61	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	4.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729460	135708	None	0	Human	Functional	pEC50	=	9.2	9.2	61	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	4.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1	nan
	67495611	136152	None	0	Human	Functional	pEC50	=	9.2	9.2	933	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	4.3	CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3732081	136152	None	0	Human	Functional	pEC50	=	9.2	9.2	933	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	4.3	CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	67496319	135827	None	0	Human	Functional	pEC50	=	9.1	9.1	131	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	9	2	4	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1	nan
	CHEMBL3730159	135827	None	0	Human	Functional	pEC50	=	9.1	9.1	131	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	9	2	4	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1	nan
	67495075	135990	None	0	Human	Functional	pEC50	=	9.1	9.1	3235	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	5	3	3	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	CHEMBL3731113	135990	None	0	Human	Functional	pEC50	=	9.1	9.1	3235	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	5	3	3	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	67496410	136293	None	0	Human	Functional	pEC50	=	9.1	9.1	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.3	O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732902	136293	None	0	Human	Functional	pEC50	=	9.1	9.1	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.3	O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	71526099	182496	None	2	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113194
	CHEMBL4785302	182496	None	2	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113194
	67495605	136077	None	0	Human	Functional	pEC50	=	9.1	9.1	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	528	8	2	4	3.8	CN1CCCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3731635	136077	None	0	Human	Functional	pEC50	=	9.1	9.1	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	528	8	2	4	3.8	CN1CCCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496025	135639	None	0	Human	Functional	pEC50	=	9.0	9.0	1621	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	429	4	3	3	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1	nan
	CHEMBL3729013	135639	None	0	Human	Functional	pEC50	=	9.0	9.0	1621	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	429	4	3	3	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1	nan
	67495735	135676	None	0	Human	Functional	pEC50	=	9.0	9.0	741	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	3	3	3.3	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729228	135676	None	0	Human	Functional	pEC50	=	9.0	9.0	741	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	3	3	3.3	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	457933	218213	None	24	Human	Functional	pEC50	=	9	9.0	10	3	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C	10.1021/jm900592h
	CHEMBL552527	218213	None	24	Human	Functional	pEC50	=	9	9.0	10	3	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C	10.1021/jm900592h
	67495663	135680	None	0	Human	Functional	pEC50	=	9	9.0	331	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	3	4.5	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729246	135680	None	0	Human	Functional	pEC50	=	9	9.0	331	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	3	4.5	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496799	136048	None	0	Human	Functional	pEC50	=	9	9.0	1288	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	6	3	3	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	CHEMBL3731461	136048	None	0	Human	Functional	pEC50	=	9	9.0	1288	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	6	3	3	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	71525458	91747	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	413	7	4	3	3.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NC(C)(C)C(=O)O	10.1021/ml400179m
	CHEMBL2408793	91747	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	413	7	4	3	3.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NC(C)(C)C(=O)O	10.1021/ml400179m
	87422149	135998	None	0	Human	Functional	pEC50	=	9.0	9.0	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731163	135998	None	0	Human	Functional	pEC50	=	9.0	9.0	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495489	136113	None	0	Human	Functional	pEC50	=	9.0	9.0	4265	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	3	3	2.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731849	136113	None	0	Human	Functional	pEC50	=	9.0	9.0	4265	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	3	3	2.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	89685025	135833	None	0	Human	Functional	pEC50	=	8.9	8.9	1412	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	529	4	2	4	4.3	CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	CHEMBL3730197	135833	None	0	Human	Functional	pEC50	=	8.9	8.9	1412	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	529	4	2	4	4.3	CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	87422150	135511	None	0	Human	Functional	pEC50	=	8.9	8.9	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	8	3	5	2.9	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728245	135511	None	0	Human	Functional	pEC50	=	8.9	8.9	512	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	8	3	5	2.9	NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495157	135717	None	0	Human	Functional	pEC50	=	8.9	8.9	3388	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	4	2	2	4.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCC1)C21CC1	nan
	CHEMBL3729500	135717	None	0	Human	Functional	pEC50	=	8.9	8.9	3388	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	4	2	2	4.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCC1)C21CC1	nan
	127036711	135855	None	0	Human	Functional	pEC50	=	8.9	8.9	47	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	9	2	4	3.5	O=C(NCc1ccc(Br)nc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730330	135855	None	0	Human	Functional	pEC50	=	8.9	8.9	47	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	9	2	4	3.5	O=C(NCc1ccc(Br)nc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496296	136122	None	0	Human	Functional	pEC50	=	8.9	8.9	89	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.3	O=C(Nc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731889	136122	None	0	Human	Functional	pEC50	=	8.9	8.9	89	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.3	O=C(Nc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496273	136237	None	0	Human	Functional	pEC50	=	8.9	8.9	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	7	2	4	3.2	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)CC1	nan
	CHEMBL3732566	136237	None	0	Human	Functional	pEC50	=	8.9	8.9	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	7	2	4	3.2	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)CC1	nan
	87422149	135998	None	0	Human	Functional	pEC50	=	8.9	8.9	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731163	135998	None	0	Human	Functional	pEC50	=	8.9	8.9	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495854	136205	None	0	Human	Functional	pEC50	=	8.9	8.9	2754	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	6	3	3	2.7	NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732404	136205	None	0	Human	Functional	pEC50	=	8.9	8.9	2754	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	6	3	3	2.7	NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495754	136402	None	0	Human	Functional	pEC50	=	8.9	8.9	5370	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	529	10	2	4	4.2	COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728573	136402	None	0	Human	Functional	pEC50	=	8.9	8.9	5370	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	529	10	2	4	4.2	COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733986	136402	None	0	Human	Functional	pEC50	=	8.9	8.9	5370	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	529	10	2	4	4.2	COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495370	135714	None	0	Human	Functional	pEC50	=	8.8	8.8	3467	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	5	2	3	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1	nan
	CHEMBL3729487	135714	None	0	Human	Functional	pEC50	=	8.8	8.8	3467	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	5	2	3	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1	nan
	87421981	135366	None	0	Human	Functional	pEC50	=	8.8	8.8	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	8	2	4	3.5	O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727408	135366	None	0	Human	Functional	pEC50	=	8.8	8.8	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	8	2	4	3.5	O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496224	135570	None	0	Human	Functional	pEC50	=	8.7	8.7	1258	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	420	6	3	3	2.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	CHEMBL3728559	135570	None	0	Human	Functional	pEC50	=	8.7	8.7	1258	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	420	6	3	3	2.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	67495939	136309	None	0	Human	Functional	pEC50	=	8.7	8.7	1096	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	8	2	3	3.8	CCOCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733012	136309	None	0	Human	Functional	pEC50	=	8.7	8.7	1096	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	8	2	3	3.8	CCOCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495657	136400	None	0	Human	Functional	pEC50	=	8.7	8.7	4168	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.6	CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1	nan
	CHEMBL3731167	136400	None	0	Human	Functional	pEC50	=	8.7	8.7	4168	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.6	CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1	nan
	CHEMBL3733984	136400	None	0	Human	Functional	pEC50	=	8.7	8.7	4168	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.6	CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1	nan
	42629962	180821	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	377	6	1	8	3.0	CC(=O)c1coc(Cn2ccc(NC(=O)c3ncoc3-c3ccccc3)n2)n1	10.1016/j.ejmech.2021.113194
	CHEMBL4755656	180821	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	377	6	1	8	3.0	CC(=O)c1coc(Cn2ccc(NC(=O)c3ncoc3-c3ccccc3)n2)n1	10.1016/j.ejmech.2021.113194
	146597621	191446	None	0	Human	Functional	pEC50	=	8	8.0	33	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5191583	191446	None	0	Human	Functional	pEC50	=	8	8.0	33	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67495008	135469	None	0	Human	Functional	pEC50	=	8	8.0	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	8	2	5	4.1	O=C(Nc1ccc2scnc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728025	135469	None	0	Human	Functional	pEC50	=	8	8.0	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	8	2	5	4.1	O=C(Nc1ccc2scnc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496354	135798	None	0	Human	Functional	pEC50	=	8	8.0	489	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	403	5	3	3	2.3	NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729988	135798	None	0	Human	Functional	pEC50	=	8	8.0	489	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	403	5	3	3	2.3	NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	57378085	153769	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	442	6	2	9	3.4	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(Cl)c2)o1	nan
	CHEMBL3981311	153769	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	442	6	2	9	3.4	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(Cl)c2)o1	nan
	57378194	150610	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	408	6	2	9	2.8	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2ccccc2)o1	nan
	CHEMBL3954589	150610	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	408	6	2	9	2.8	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2ccccc2)o1	nan
	22430370	79811	None	6	Human	Functional	pEC50	=	7	7.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	390	3	2	4	4.1	Cc1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL211885	79811	None	6	Human	Functional	pEC50	=	7	7.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	390	3	2	4	4.1	Cc1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	44413564	138858	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	396	5	2	4	4.9	CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2006.04.068
	CHEMBL378064	138858	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	396	5	2	4	4.9	CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2006.04.068
	25238441	19140	None	6	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	348	5	2	2	3.8	COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL1289381	19140	None	6	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	348	5	2	2	3.8	COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1	10.1016/j.bmc.2015.03.062
	67495644	135463	None	0	Human	Functional	pEC50	=	7	7.0	87	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	5	3	3	3.4	NC(=O)C1CCCCC1NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728007	135463	None	0	Human	Functional	pEC50	=	7	7.0	87	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	5	3	3	3.4	NC(=O)C1CCCCC1NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	71698362	90737	None	0	Human	Functional	pEC50	=	6	6.0	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	455	6	1	6	3.2	COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391446	90737	None	0	Human	Functional	pEC50	=	6	6.0	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	455	6	1	6	3.2	COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	122181323	121930	None	0	Mouse	Functional	pEC50	=	6	6.0	-2	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590074	121930	None	0	Mouse	Functional	pEC50	=	6	6.0	-2	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168273654	190435	None	0	Human	Functional	pEC50	=	6	6.0	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5176452	190435	None	0	Human	Functional	pEC50	=	6	6.0	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	708867	121978	None	12	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	347	5	2	4	4.0	COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Cl)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL3590214	121978	None	12	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	347	5	2	4	4.0	COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Cl)nc2c1	10.1016/j.bmc.2015.03.062
	87422106	135914	None	0	Human	Functional	pEC50	=	5	5.0	-46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	498	8	2	5	4.7	O=C(Nc1nc2ccc(Cl)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730690	135914	None	0	Human	Functional	pEC50	=	5	5.0	-46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	498	8	2	5	4.7	O=C(Nc1nc2ccc(Cl)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496037	136145	None	0	Human	Functional	pEC50	=	5	5.0	-27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1ccc(F)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732039	136145	None	0	Human	Functional	pEC50	=	5	5.0	-27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1ccc(F)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	24776345	155565	None	5	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	3	1	4	4.3	COc1ccc2[nH]c(C(=O)N3CCC(n4c(C)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL404003	155565	None	5	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	3	1	4	4.3	COc1ccc2[nH]c(C(=O)N3CCC(n4c(C)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	67496375	136312	None	0	Human	Functional	pEC50	=	7.0	7.0	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	7	2	2	4.5	CCCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733047	136312	None	0	Human	Functional	pEC50	=	7.0	7.0	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	7	2	2	4.5	CCCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495422	136339	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733207	136339	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL5075000	216841	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCNCC2)C1=O	10.1016/j.ejmech.2021.113805
	67495590	136389	None	0	Human	Functional	pEC50	=	5.0	5.0	-30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1	nan
	CHEMBL3730542	136389	None	0	Human	Functional	pEC50	=	5.0	5.0	-30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1	nan
	CHEMBL3733974	136389	None	0	Human	Functional	pEC50	=	5.0	5.0	-30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1	nan
	67496493	136397	None	0	Human	Functional	pEC50	=	5.0	5.0	-141	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	11	2	4	3.9	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br	nan
	CHEMBL3728781	136397	None	0	Human	Functional	pEC50	=	5.0	5.0	-141	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	11	2	4	3.9	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br	nan
	CHEMBL3733981	136397	None	0	Human	Functional	pEC50	=	5.0	5.0	-141	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	11	2	4	3.9	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br	nan
	67496529	135611	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	8	3	6	1.1	CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728812	135611	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	8	3	6	1.1	CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495926	135983	None	0	Human	Functional	pEC50	=	5.0	5.0	-524	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	497	9	2	3	4.5	CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)NCCc3ccc(Cl)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3731064	135983	None	0	Human	Functional	pEC50	=	5.0	5.0	-524	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	497	9	2	3	4.5	CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)NCCc3ccc(Cl)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	92263206	174277	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	CHEMBL4547265	174277	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry	ChEMBL	465	8	3	5	3.5	COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C	10.1039/C9MD00336C
	67495041	136322	None	0	Human	Functional	pEC50	=	7.0	7.0	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	9	3	6	3.4	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCc2nc4ccccc4[nH]2)C32CC2)n1	nan
	CHEMBL3733092	136322	None	0	Human	Functional	pEC50	=	7.0	7.0	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	9	3	6	3.4	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCc2nc4ccccc4[nH]2)C32CC2)n1	nan
	87422369	135594	None	0	Human	Functional	pEC50	=	5.0	5.0	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	490	9	2	4	3.8	O=C(NCc1cc(Cl)nc(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728722	135594	None	0	Human	Functional	pEC50	=	5.0	5.0	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	490	9	2	4	3.8	O=C(NCc1cc(Cl)nc(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44236330	194956	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	194956	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	155524563	171028	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4455225	171028	None	0	Human	Functional	pEC50	=	5.0	5.0	1	2	Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry	ChEMBL	435	9	3	4	3.2	COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	87422340	135796	None	0	Human	Functional	pEC50	=	8.0	8.0	831	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	8	3	6	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCOCCO)C21CC1	nan
	CHEMBL3729977	135796	None	0	Human	Functional	pEC50	=	8.0	8.0	831	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	8	3	6	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCOCCO)C21CC1	nan
	67495887	135927	None	0	Human	Functional	pEC50	=	8.0	8.0	380	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	1	3	3.2	CN(C)CCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730777	135927	None	0	Human	Functional	pEC50	=	8.0	8.0	380	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	1	3	3.2	CN(C)CCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496610	136027	None	0	Human	Functional	pEC50	=	8.0	8.0	144	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	531	8	3	4	4.6	CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731311	136027	None	0	Human	Functional	pEC50	=	8.0	8.0	144	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	531	8	3	4	4.6	CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496373	136405	None	0	Human	Functional	pEC50	=	8.0	8.0	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	8	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730922	136405	None	0	Human	Functional	pEC50	=	8.0	8.0	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	8	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733989	136405	None	0	Human	Functional	pEC50	=	8.0	8.0	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	8	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	57378198	154189	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	408	6	2	9	2.8	Cc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	CHEMBL3984964	154189	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	408	6	2	9	2.8	Cc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	57377975	153196	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	422	6	2	9	3.1	Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	CHEMBL3976318	153196	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	422	6	2	9	3.1	Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	162657722	181248	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	436	4	3	3	4.6	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4760670	181248	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	436	4	3	3	4.6	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1	10.1016/j.ejmech.2021.113194
	145954612	162665	None	0	Human	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4168567	162665	None	0	Human	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	168270850	190008	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	377	3	2	3	3.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)ccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5169641	190008	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	377	3	2	3	3.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)ccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	162659418	181340	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	433	5	3	4	4.3	CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4761559	181340	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	433	5	3	4	4.3	CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	122181324	121931	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590075	121931	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	44233646	198879	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	198879	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	44233646	198879	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	198879	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	168291793	192040	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5200365	192040	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	67496049	135514	None	0	Human	Functional	pEC50	=	5.0	5.0	-42	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1ccc(C)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	CHEMBL3728279	135514	None	0	Human	Functional	pEC50	=	5.0	5.0	-42	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1ccc(C)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	67495233	135878	None	0	Human	Functional	pEC50	=	7.0	7.0	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	6	2	4	4.8	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1ccnn1-c1ccccc1	nan
	CHEMBL3730474	135878	None	0	Human	Functional	pEC50	=	7.0	7.0	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	516	6	2	4	4.8	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1ccnn1-c1ccccc1	nan
	67495759	136169	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	447	7	3	3	2.1	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3732166	136169	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	447	7	3	3	2.1	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	164916035	192459	None	3	Human	Functional	pEC50	=	6.0	6.0	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5207056	192459	None	3	Human	Functional	pEC50	=	6.0	6.0	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	1599	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	3955	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	3955.0	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	7215	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	CHEMBL841	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	DB00836	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-616	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	67495025	136052	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	2.6	NC(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731489	136052	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	2.6	NC(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	71699060	90730	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391437	90730	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	67495872	136063	None	0	Human	Functional	pEC50	=	6.9	6.9	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	5	2	4	3.7	Cc1cc(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C	nan
	CHEMBL3731544	136063	None	0	Human	Functional	pEC50	=	6.9	6.9	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	5	2	4	3.7	Cc1cc(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C	nan
	71698880	90708	None	0	Human	Functional	pEC50	=	4.9	4.9	-2	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	411	5	1	4	3.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391277	90708	None	0	Human	Functional	pEC50	=	4.9	4.9	-2	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	411	5	1	4	3.5	Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	67495767	135614	None	0	Human	Functional	pEC50	=	6.9	6.9	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728830	135614	None	0	Human	Functional	pEC50	=	6.9	6.9	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496309	135738	None	0	Human	Functional	pEC50	=	6.9	6.9	56	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	5	2	3	3.7	CC(NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)N1CCCCC1	nan
	CHEMBL3729615	135738	None	0	Human	Functional	pEC50	=	6.9	6.9	56	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	5	2	3	3.7	CC(NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)N1CCCCC1	nan
	67495874	136228	None	0	Human	Functional	pEC50	=	6.9	6.9	27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	5	2	3	4.3	Cc1ccncc1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732516	136228	None	0	Human	Functional	pEC50	=	6.9	6.9	27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	5	2	3	4.3	Cc1ccncc1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	44232924	197779	None	0	Human	Functional	pEC50	=	4.9	4.9	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	197779	None	0	Human	Functional	pEC50	=	4.9	4.9	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44232924	197779	None	0	Human	Functional	pEC50	=	4.9	4.9	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	197779	None	0	Human	Functional	pEC50	=	4.9	4.9	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	67495436	136374	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	CHEMBL3728119	136374	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	CHEMBL3733941	136374	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	127024138	136028	None	0	Human	Functional	pEC50	=	5.9	5.9	-75	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	549	10	2	3	4.2	O=C(NCCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731316	136028	None	0	Human	Functional	pEC50	=	5.9	5.9	-75	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	549	10	2	3	4.2	O=C(NCCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87422013	135739	None	0	Human	Functional	pEC50	=	7.9	7.9	134	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	6	3	5	2.8	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729617	135739	None	0	Human	Functional	pEC50	=	7.9	7.9	134	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	6	3	5	2.8	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495280	135949	None	0	Human	Functional	pEC50	=	7.9	7.9	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	6	2	4	4.2	CN(CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)OC(C)(C)C	nan
	CHEMBL3730902	135949	None	0	Human	Functional	pEC50	=	7.9	7.9	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	6	2	4	4.2	CN(CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)OC(C)(C)C	nan
	67494881	136072	None	0	Human	Functional	pEC50	=	7.9	7.9	114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	6	2	3	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCCC1)C21CC1	nan
	CHEMBL3731600	136072	None	0	Human	Functional	pEC50	=	7.9	7.9	114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	6	2	3	3.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCCC1)C21CC1	nan
	67495727	136224	None	0	Human	Functional	pEC50	=	7.9	7.9	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	6	2	5	2.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCn1cncn1)C21CC1	nan
	CHEMBL3732504	136224	None	0	Human	Functional	pEC50	=	7.9	7.9	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	6	2	5	2.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCn1cncn1)C21CC1	nan
	57378082	147891	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	438	7	2	10	2.8	COc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	CHEMBL3932747	147891	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	438	7	2	10	2.8	COc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	145949892	162915	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172556	162915	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	87421942	135456	None	0	Human	Functional	pEC50	=	6.9	6.9	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	9	2	7	2.8	O=C(Nc1ncc([N+](=O)[O-])s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727914	135456	None	0	Human	Functional	pEC50	=	6.9	6.9	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	9	2	7	2.8	O=C(Nc1ncc([N+](=O)[O-])s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44233647	197991	None	0	Human	Functional	pEC50	=	5.9	5.9	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	197991	None	0	Human	Functional	pEC50	=	5.9	5.9	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	44233647	197991	None	0	Human	Functional	pEC50	=	5.9	5.9	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	197991	None	0	Human	Functional	pEC50	=	5.9	5.9	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	87422045	135795	None	0	Human	Functional	pEC50	=	6.9	6.9	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	8	2	5	3.6	O=C(Nc1ncc(Cl)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729966	135795	None	0	Human	Functional	pEC50	=	6.9	6.9	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	8	2	5	3.6	O=C(Nc1ncc(Cl)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496039	136173	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	11	2	3	4.1	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732195	136173	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	11	2	3	4.1	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	24776356	167629	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	442	4	1	4	5.1	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC(F)(F)F)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL430016	167629	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	442	4	1	4	5.1	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC(F)(F)F)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	67495634	135911	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	533	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCN(Cc3ccccc3)CC1)C21CC1	nan
	CHEMBL3730675	135911	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	533	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCN(Cc3ccccc3)CC1)C21CC1	nan
	22430372	140214	None	9	Human	Functional	pEC50	=	4.9	4.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	364	4	2	4	4.3	Cc1c(NC(=O)Nc2ccc(C(C)C)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL380160	140214	None	9	Human	Functional	pEC50	=	4.9	4.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	364	4	2	4	4.3	Cc1c(NC(=O)Nc2ccc(C(C)C)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	44232677	198802	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	408	7	1	7	2.7	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL562456	198802	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	408	7	1	7	2.7	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1	10.1021/jm900592h
	162653824	180594	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	447	6	3	4	4.5	CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4753061	180594	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	447	6	3	4	4.5	CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1	10.1016/j.ejmech.2021.113194
	67496284	135669	None	0	Human	Functional	pEC50	=	6.9	6.9	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	5	2	2	4.0	CC(C)C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729198	135669	None	0	Human	Functional	pEC50	=	6.9	6.9	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	5	2	2	4.0	CC(C)C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	909951	172784	None	10	Human	Functional	pEC50	=	5.9	5.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	336	3	2	4	3.4	Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL450023	172784	None	10	Human	Functional	pEC50	=	5.9	5.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	336	3	2	4	3.4	Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	67496639	136377	None	0	Human	Functional	pEC50	=	5.9	5.9	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	505	10	2	4	4.0	O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729738	136377	None	0	Human	Functional	pEC50	=	5.9	5.9	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	505	10	2	4	4.0	O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733944	136377	None	0	Human	Functional	pEC50	=	5.9	5.9	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	505	10	2	4	4.0	O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	122181233	121914	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589947	121914	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	87422138	136142	None	0	Human	Functional	pEC50	=	6.9	6.9	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1(O)CCCCC1)C21CC1	nan
	CHEMBL3732017	136142	None	0	Human	Functional	pEC50	=	6.9	6.9	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1(O)CCCCC1)C21CC1	nan
	67495929	135368	None	0	Human	Functional	pEC50	=	7.9	7.9	186	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.2	Cc1cc(C)n(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)n1	nan
	CHEMBL3727417	135368	None	0	Human	Functional	pEC50	=	7.9	7.9	186	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.2	Cc1cc(C)n(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)n1	nan
	67495288	135394	None	0	Human	Functional	pEC50	=	7.9	7.9	83	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	5	2	3	4.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCc1ccoc1)C21CC1	nan
	CHEMBL3727544	135394	None	0	Human	Functional	pEC50	=	7.9	7.9	83	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	5	2	3	4.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCc1ccoc1)C21CC1	nan
	67495409	135650	None	0	Human	Functional	pEC50	=	7.9	7.9	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729082	135650	None	0	Human	Functional	pEC50	=	7.9	7.9	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495697	135926	None	0	Human	Functional	pEC50	=	7.9	7.9	131	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	5	3	3	3.9	NC[C@H]1CC[C@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3730760	135926	None	0	Human	Functional	pEC50	=	7.9	7.9	131	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	5	3	3	3.9	NC[C@H]1CC[C@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496347	135952	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	519	9	2	3	4.2	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730919	135952	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	519	9	2	3	4.2	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87421983	136340	None	0	Human	Functional	pEC50	=	7.9	7.9	162	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	426	6	3	5	2.2	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3733217	136340	None	0	Human	Functional	pEC50	=	7.9	7.9	162	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	426	6	3	5	2.2	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	57378197	153833	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	426	6	2	9	2.9	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(F)c2)o1	nan
	CHEMBL3981821	153833	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	426	6	2	9	2.9	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(F)c2)o1	nan
	98363171	121795	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	540	7	3	4	4.5	CCOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1	10.1016/j.bmc.2015.03.062
	CHEMBL3588923	121795	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	540	7	3	4	4.5	CCOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1	10.1016/j.bmc.2015.03.062
	CHEMBL5087410	217586	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	24776350	94108	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL248928	94108	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	162645753	179618	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	444	6	3	3	4.9	O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4741207	179618	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	444	6	3	3	4.9	O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	145951856	162986	None	0	Human	Functional	pEC50	=	5.9	5.9	8	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4173645	162986	None	0	Human	Functional	pEC50	=	5.9	5.9	8	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	168282661	191099	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	358	4	3	4	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc3ccccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5186339	191099	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	358	4	3	4	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc3ccccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	168269851	190075	None	0	Human	Functional	pEC50	=	5.9	5.9	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5170711	190075	None	0	Human	Functional	pEC50	=	5.9	5.9	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	67495955	135600	None	0	Human	Functional	pEC50	=	6.9	6.9	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	3	4.1	CCN1CCC(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3728768	135600	None	0	Human	Functional	pEC50	=	6.9	6.9	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	3	4.1	CCN1CCC(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496243	136382	None	0	Human	Functional	pEC50	=	6.9	6.9	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	422	8	2	4	3.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	CHEMBL3727715	136382	None	0	Human	Functional	pEC50	=	6.9	6.9	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	422	8	2	4	3.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	CHEMBL3733949	136382	None	0	Human	Functional	pEC50	=	6.9	6.9	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	422	8	2	4	3.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	44233905	198789	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562380	198789	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	44233905	198789	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562380	198789	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	67495244	135741	None	0	Human	Functional	pEC50	=	6.9	6.9	41	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	458	8	1	2	5.3	CCCCCCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729626	135741	None	0	Human	Functional	pEC50	=	6.9	6.9	41	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	458	8	1	2	5.3	CCCCCCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422067	135753	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	8	2	5	2.9	O=C(Nc1cnc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729699	135753	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	8	2	5	2.9	O=C(Nc1cnc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	168278342	191260	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5188537	191260	None	0	Human	Functional	pEC50	=	4.9	4.9	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	67495124	136164	None	0	Human	Functional	pEC50	=	6.9	6.9	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	7	2	3	4.4	O=C(CCc1cccnc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732149	136164	None	0	Human	Functional	pEC50	=	6.9	6.9	35	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	7	2	3	4.4	O=C(CCc1cccnc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL5085818	217480	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O	10.1016/j.ejmech.2021.113805
	CHEMBL5087410	217586	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	87422026	135980	None	0	Human	Functional	pEC50	=	7.9	7.9	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	7	3	5	2.6	CNCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3731053	135980	None	0	Human	Functional	pEC50	=	7.9	7.9	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	7	3	5	2.6	CNCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	44413524	78087	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	370	4	2	4	4.0	CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL209995	78087	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	370	4	2	4	4.0	CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	93095777	121797	None	1	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	415	5	2	2	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCC1	10.1016/j.bmc.2015.03.062
	CHEMBL3588925	121797	None	1	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	415	5	2	2	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCC1	10.1016/j.bmc.2015.03.062
	122180577	121794	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay	ChEMBL	721	13	2	6	4.9	CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O	10.1016/j.bmc.2015.03.062
	CHEMBL3588922	121794	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay	ChEMBL	721	13	2	6	4.9	CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O	10.1016/j.bmc.2015.03.062
	67495871	135775	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	9	2	6	2.4	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3729817	135775	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	9	2	6	2.4	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCCC2)C32CC2)n1	nan
	67495536	136020	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3731264	136020	None	0	Human	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	145954612	162665	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4168567	162665	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	71699059	90713	None	0	Human	Functional	pEC50	=	4.9	4.9	-3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391286	90713	None	0	Human	Functional	pEC50	=	4.9	4.9	-3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	417	5	1	5	3.6	Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	24776354	94189	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	392	3	1	3	4.8	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL249339	94189	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	392	3	1	3	4.8	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL5078594	217056	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O	10.1016/j.ejmech.2021.113805
	44233646	198879	None	0	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562910	198879	None	0	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	393	7	1	6	2.8	COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1	10.1021/jm900592h
	67495472	135781	None	0	Human	Functional	pEC50	=	6.8	6.8	57	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	5	2	2	4.8	CC(C)(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729866	135781	None	0	Human	Functional	pEC50	=	6.8	6.8	57	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	5	2	2	4.8	CC(C)(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495703	136167	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	7	3	3	2.0	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732159	136167	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	7	3	3	2.0	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	89684942	135692	None	0	Human	Functional	pEC50	=	6.8	6.8	46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	4	2	3	3.4	CN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3729343	135692	None	0	Human	Functional	pEC50	=	6.8	6.8	46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	4	2	3	3.4	CN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	44413499	78211	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	427	3	2	6	3.9	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(C2=NCCS2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL210475	78211	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	427	3	2	6	3.9	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(C2=NCCS2)n1C	10.1016/j.bmcl.2006.04.068
	122181411	121980	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay	ChEMBL	415	7	2	4	5.4	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590216	121980	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay	ChEMBL	415	7	2	4	5.4	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1	10.1016/j.bmc.2015.03.062
	24776353	94188	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	376	3	1	3	4.3	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL249338	94188	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	376	3	1	3	4.3	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	87422020	135992	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	6	3	5	1.9	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3731133	135992	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	440	6	3	5	1.9	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	44413646	79747	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	420	4	2	6	3.8	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cncnc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL211555	79747	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	420	4	2	6	3.8	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cncnc2)n1C	10.1016/j.bmcl.2006.04.068
	145978177	163156	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4176353	163156	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	145956762	162262	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162303	162262	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL5088283	217640	None	3	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		N#Cc1ccc(NC(=O)NC2CCN(c3ccccc3F)C2=O)cc1	10.1016/j.ejmech.2021.113805
	24776348	94593	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	442	3	1	4	5.0	COc1ccc2[nH]c(C(=O)N3CCC(n4c(C(F)(F)F)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL251772	94593	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	442	3	1	4	5.0	COc1ccc2[nH]c(C(=O)N3CCC(n4c(C(F)(F)F)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	67495369	136035	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)co1	nan
	CHEMBL3731379	136035	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)co1	nan
	67495671	135752	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	3.5	O=C(NCc1c(F)cc(F)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729697	135752	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	3.5	O=C(NCc1c(F)cc(F)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496282	135396	None	0	Human	Functional	pEC50	=	6.8	6.8	46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	7	1	3	3.7	COCCC(=O)N(C)C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727591	135396	None	0	Human	Functional	pEC50	=	6.8	6.8	46	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	7	1	3	3.7	COCCC(=O)N(C)C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422036	135850	None	0	Human	Functional	pEC50	=	5.8	5.8	-9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730289	135850	None	0	Human	Functional	pEC50	=	5.8	5.8	-9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495650	135816	None	0	Human	Functional	pEC50	=	6.8	6.8	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	7	2	4	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCOCC1)C21CC1	nan
	CHEMBL3730081	135816	None	0	Human	Functional	pEC50	=	6.8	6.8	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	7	2	4	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCOCC1)C21CC1	nan
	67495428	135531	None	0	Human	Functional	pEC50	=	6.8	6.8	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	2	5.4	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cccc(F)c1Cl	nan
	CHEMBL3728360	135531	None	0	Human	Functional	pEC50	=	6.8	6.8	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	2	5.4	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cccc(F)c1Cl	nan
	87421982	135912	None	0	Human	Functional	pEC50	=	6.8	6.8	134	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	413	5	3	5	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCO)C21CC1	nan
	CHEMBL3730683	135912	None	0	Human	Functional	pEC50	=	6.8	6.8	134	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	413	5	3	5	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCO)C21CC1	nan
	67495469	135467	None	0	Human	Functional	pEC50	=	7.8	7.8	162	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	2	3	3.8	CCN1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728012	135467	None	0	Human	Functional	pEC50	=	7.8	7.8	162	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	2	3	3.8	CCN1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495506	135678	None	0	Human	Functional	pEC50	=	7.8	7.8	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	7	2	3	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	CHEMBL3729242	135678	None	0	Human	Functional	pEC50	=	7.8	7.8	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	7	2	3	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	67495743	136266	None	0	Human	Functional	pEC50	=	7.8	7.8	316	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	2	3	3.4	COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732748	136266	None	0	Human	Functional	pEC50	=	7.8	7.8	316	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	2	3	3.4	COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	93095555	121971	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	501	7	2	4	4.0	CCOC(=O)C1CCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)CC1	10.1016/j.bmc.2015.03.062
	CHEMBL3590207	121971	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	501	7	2	4	4.0	CCOC(=O)C1CCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)CC1	10.1016/j.bmc.2015.03.062
	168295559	192312	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	384	5	2	6	3.1	COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)cc1	10.1021/acsmedchemlett.2c00079
	CHEMBL5204580	192312	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	384	5	2	6	3.1	COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)cc1	10.1021/acsmedchemlett.2c00079
	168283038	191036	None	0	Human	Functional	pEC50	=	6.8	6.8	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185462	191036	None	0	Human	Functional	pEC50	=	6.8	6.8	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	163322252	191989	None	9	Human	Functional	pEC50	=	6.8	6.8	26	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5199629	191989	None	9	Human	Functional	pEC50	=	6.8	6.8	26	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	67496420	135609	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	4.2	O=C(CCCN1CCCC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728805	135609	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	4.2	O=C(CCCN1CCCC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	162645401	179779	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	422	4	3	3	3.1	CN1CCC(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)CC1	10.1016/j.ejmech.2021.113194
	CHEMBL4743451	179779	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	422	4	3	3	3.1	CN1CCC(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)CC1	10.1016/j.ejmech.2021.113194
	44236328	198132	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	198132	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	44236328	198132	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	198132	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	168284664	191622	None	0	Human	Functional	pEC50	=	5.8	5.8	7	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	488	5	2	3	4.9	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5193947	191622	None	0	Human	Functional	pEC50	=	5.8	5.8	7	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	488	5	2	3	4.9	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21	10.1021/acs.jmedchem.1c02203
	122181233	121914	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589947	121914	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145952664	162528	None	0	Human	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4166385	162528	None	0	Human	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	87422011	136335	None	0	Human	Functional	pEC50	=	6.8	6.8	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	8	2	6	2.8	N#Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL3733176	136335	None	0	Human	Functional	pEC50	=	6.8	6.8	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	8	2	6	2.8	N#Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	87422037	135817	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	504	8	2	4	3.7	O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730082	135817	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	504	8	2	4	3.7	O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495638	136047	None	0	Human	Functional	pEC50	=	6.8	6.8	56	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	7	3	3	4.0	Cc1[nH]ncc1CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731458	136047	None	0	Human	Functional	pEC50	=	6.8	6.8	56	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	7	3	3	4.0	Cc1[nH]ncc1CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	44233647	197991	None	0	Human	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	CHEMBL554291	197991	None	0	Human	Functional	pEC50	=	4.8	4.8	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	423	8	1	7	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1	10.1021/jm900592h
	71699139	90736	None	0	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	493	5	1	4	4.0	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391443	90736	None	0	Human	Functional	pEC50	=	4.8	4.8	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	493	5	1	4	4.0	Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	67496376	135545	None	0	Human	Functional	pEC50	=	7.8	7.8	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	7	3	4	4.2	CC(C)(C)OC(=O)NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728451	135545	None	0	Human	Functional	pEC50	=	7.8	7.8	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	7	3	4	4.2	CC(C)(C)OC(=O)NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495567	135663	None	0	Human	Functional	pEC50	=	7.8	7.8	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729170	135663	None	0	Human	Functional	pEC50	=	7.8	7.8	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87421986	135727	None	0	Human	Functional	pEC50	=	7.8	7.8	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729552	135727	None	0	Human	Functional	pEC50	=	7.8	7.8	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87421962	135892	None	0	Human	Functional	pEC50	=	7.8	7.8	275	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	450	4	3	5	2.5	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	CHEMBL3730548	135892	None	0	Human	Functional	pEC50	=	7.8	7.8	275	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	450	4	3	5	2.5	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	57378305	153997	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	424	7	2	10	2.5	COc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	CHEMBL3983228	153997	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	424	7	2	10	2.5	COc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	57378084	148586	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	428	6	2	9	3.1	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3cccc(Cl)c3)n2)n1	nan
	CHEMBL3938248	148586	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	428	6	2	9	3.1	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3cccc(Cl)c3)n2)n1	nan
	285404	80354	None	7	Human	Functional	pEC50	=	6.8	6.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	368	4	2	5	3.9	CSc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL214216	80354	None	7	Human	Functional	pEC50	=	6.8	6.8	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	368	4	2	5	3.9	CSc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	164916034	191799	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5196771	191799	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	67495076	136123	None	0	Human	Functional	pEC50	=	6.8	6.8	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3731893	136123	None	0	Human	Functional	pEC50	=	6.8	6.8	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	71698365	90738	None	0	Human	Functional	pEC50	=	5.8	5.8	7	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	484	7	2	7	3.9	COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391447	90738	None	0	Human	Functional	pEC50	=	5.8	5.8	7	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	484	7	2	7	3.9	COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	122181233	121914	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589947	121914	None	0	Mouse	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145952664	162528	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4166385	162528	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	500	9	3	4	4.6	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	145955803	162741	None	0	Human	Functional	pEC50	=	5.8	5.8	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	CHEMBL4169807	162741	None	0	Human	Functional	pEC50	=	5.8	5.8	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	168283929	191209	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187763	191209	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	67496815	135615	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	411	9	2	4	2.7	O=C(NCc1ccco1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728843	135615	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	411	9	2	4	2.7	O=C(NCc1ccco1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87422329	136018	None	0	Human	Functional	pEC50	=	6.8	6.8	17	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	7	3	5	4.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	CHEMBL3731251	136018	None	0	Human	Functional	pEC50	=	6.8	6.8	17	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	7	3	5	4.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	67496263	135461	None	0	Human	Functional	pEC50	=	5.8	5.8	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	10	2	3	3.8	O=C(NCCC1=CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727975	135461	None	0	Human	Functional	pEC50	=	5.8	5.8	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	10	2	3	3.8	O=C(NCCC1=CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162644943	179507	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	4	3	3	4.2	Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1	10.1016/j.ejmech.2021.113194
	CHEMBL4739971	179507	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	4	3	3	4.2	Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1	10.1016/j.ejmech.2021.113194
	67495551	135474	None	0	Human	Functional	pEC50	=	7.8	7.8	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	4	2	4	4.7	CC(C)(C)OC(=O)N1CCCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	CHEMBL3728062	135474	None	0	Human	Functional	pEC50	=	7.8	7.8	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	4	2	4	4.7	CC(C)(C)OC(=O)N1CCCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	67495429	135803	None	0	Human	Functional	pEC50	=	7.8	7.8	380	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	7	2	5	3.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cncn1)C21CC1	nan
	CHEMBL3730013	135803	None	0	Human	Functional	pEC50	=	7.8	7.8	380	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	7	2	5	3.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cncn1)C21CC1	nan
	122181320	121928	None	0	Human	Functional	pEC50	=	5.8	5.8	5	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590071	121928	None	0	Human	Functional	pEC50	=	5.8	5.8	5	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181322	121929	None	0	Human	Functional	pEC50	=	5.8	5.8	1	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590073	121929	None	0	Human	Functional	pEC50	=	5.8	5.8	1	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	44233644	198546	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	198546	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	44233644	198546	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	198546	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	145956276	162771	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4170201	162771	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	67495817	136284	None	0	Human	Functional	pEC50	=	5.8	5.8	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(C)c1	nan
	CHEMBL3732842	136284	None	0	Human	Functional	pEC50	=	5.8	5.8	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(C)c1	nan
	67495074	136327	None	0	Human	Functional	pEC50	=	6.7	6.7	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	7	3	3	2.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	CHEMBL3733127	136327	None	0	Human	Functional	pEC50	=	6.7	6.7	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	7	3	3	2.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	24776358	154968	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	389	4	1	5	3.6	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2nc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL400723	154968	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	389	4	1	5	3.6	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2nc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	87422073	135457	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	4	2	5	2.9	NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3727924	135457	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	4	2	5	2.9	NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496407	135648	None	0	Human	Functional	pEC50	=	7.7	7.7	77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	3.1	NCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1	nan
	CHEMBL3729077	135648	None	0	Human	Functional	pEC50	=	7.7	7.7	77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	3.1	NCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1	nan
	67495744	136071	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	6	3	3	3.9	Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)[nH]c1C	nan
	CHEMBL3731599	136071	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	6	3	3	3.9	Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)[nH]c1C	nan
	145958736	162310	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162930	162310	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	122181231	121772	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL3588871	121772	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	44233648	197314	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	197314	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	44233648	197314	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	197314	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	67495857	135613	None	0	Human	Functional	pEC50	=	6.7	6.7	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	6	2	2	3.7	CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728826	135613	None	0	Human	Functional	pEC50	=	6.7	6.7	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	6	2	2	3.7	CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495889	135625	None	0	Human	Functional	pEC50	=	6.7	6.7	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	7	2	4	4.5	CC(C)(C)OC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728883	135625	None	0	Human	Functional	pEC50	=	6.7	6.7	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	7	2	4	4.5	CC(C)(C)OC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	168296342	192556	None	0	Human	Functional	pEC50	=	4.7	4.7	2	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5208434	192556	None	0	Human	Functional	pEC50	=	4.7	4.7	2	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	71525548	91745	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	385	7	4	3	2.2	CC[C@@H](C)[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1021/ml400179m
	CHEMBL2408791	91745	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	385	7	4	3	2.2	CC[C@@H](C)[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1021/ml400179m
	127034861	135593	None	0	Human	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	579	8	3	5	5.3	CC(C)(C)OC(=O)CNc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	CHEMBL3728708	135593	None	0	Human	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	579	8	3	5	5.3	CC(C)(C)OC(=O)CNc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	168293205	192247	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	430	5	2	3	3.7	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5203658	192247	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	430	5	2	3	3.7	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5085666	217468	None	5	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccc(F)cc2)C1=O	10.1016/j.ejmech.2021.113805
	67494874	135521	None	0	Human	Functional	pEC50	=	8.7	8.7	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	9	2	4	3.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728297	135521	None	0	Human	Functional	pEC50	=	8.7	8.7	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	9	2	4	3.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67496426	136320	None	0	Human	Functional	pEC50	=	8.7	8.7	275	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	5	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1	nan
	CHEMBL3733084	136320	None	0	Human	Functional	pEC50	=	8.7	8.7	275	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	5	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1	nan
	67495934	135508	None	0	Human	Functional	pEC50	=	8.7	8.7	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	8	2	3	5.0	CC1CCC(C)N1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728238	135508	None	0	Human	Functional	pEC50	=	8.7	8.7	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	8	2	3	5.0	CC1CCC(C)N1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422059	135659	None	0	Human	Functional	pEC50	=	8.7	8.7	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.2	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCCN1)C21CC1	nan
	CHEMBL3729130	135659	None	0	Human	Functional	pEC50	=	8.7	8.7	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.2	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCCN1)C21CC1	nan
	67495856	135762	None	0	Human	Functional	pEC50	=	8.7	8.7	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CN3CCCC3)CC1)C21CC1	nan
	CHEMBL3729758	135762	None	0	Human	Functional	pEC50	=	8.7	8.7	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CN3CCCC3)CC1)C21CC1	nan
	67495763	135974	None	0	Human	Functional	pEC50	=	8.6	8.6	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	528	9	2	4	3.8	CCN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3731035	135974	None	0	Human	Functional	pEC50	=	8.6	8.6	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	528	9	2	4	3.8	CCN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	71525378	91746	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	403	7	4	3	3.2	CC(C)C[C@H](NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NC(C)(C)C(=O)O	10.1021/ml400179m
	CHEMBL2408792	91746	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay	ChEMBL	403	7	4	3	3.2	CC(C)C[C@H](NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NC(C)(C)C(=O)O	10.1021/ml400179m
	67495388	135759	None	0	Human	Functional	pEC50	=	8.6	8.6	1023	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	4	2	2	3.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(F)(F)F)C21CC1	nan
	CHEMBL3729752	135759	None	0	Human	Functional	pEC50	=	8.6	8.6	1023	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	4	2	2	3.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(F)(F)F)C21CC1	nan
	67495426	136179	None	0	Human	Functional	pEC50	=	8.6	8.6	1548	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	474	6	3	3	2.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	CHEMBL3732225	136179	None	0	Human	Functional	pEC50	=	8.6	8.6	1548	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	474	6	3	3	2.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	67495799	135688	None	0	Human	Functional	pEC50	=	8.6	8.6	109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	527	6	2	4	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@@H]1CC[C@@H](CN3CCCC3)OC1)C21CC1	nan
	CHEMBL3729306	135688	None	0	Human	Functional	pEC50	=	8.6	8.6	109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	527	6	2	4	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@@H]1CC[C@@H](CN3CCCC3)OC1)C21CC1	nan
	87422009	136049	None	0	Human	Functional	pEC50	=	8.6	8.6	1071	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	406	5	2	2	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	CHEMBL3731469	136049	None	0	Human	Functional	pEC50	=	8.6	8.6	1071	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	406	5	2	2	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	67495215	135884	None	0	Human	Functional	pEC50	=	8.6	8.6	602	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	6	3	3	2.6	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730502	135884	None	0	Human	Functional	pEC50	=	8.6	8.6	602	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	6	3	3	2.6	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	162650379	180147	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	446	4	3	4	2.7	O=C(Nc1ccc(Br)nc1)C1C(C(=O)NC2CCNCC2)C2CCC1C21CC1	10.1016/j.ejmech.2021.113194
	CHEMBL4747556	180147	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	446	4	3	4	2.7	O=C(Nc1ccc(Br)nc1)C1C(C(=O)NC2CCNCC2)C2CCC1C21CC1	10.1016/j.ejmech.2021.113194
	67495567	135663	None	0	Human	Functional	pEC50	=	8.5	8.5	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729170	135663	None	0	Human	Functional	pEC50	=	8.5	8.5	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	8	2	4	3.6	O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162660631	181383	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	5	3	3	4.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4762142	181383	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	5	3	3	4.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	67495925	135616	None	0	Human	Functional	pEC50	=	7.7	7.7	309	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	6	2	2	4.4	CC(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728852	135616	None	0	Human	Functional	pEC50	=	7.7	7.7	309	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	6	2	2	4.4	CC(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495001	135575	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	5	2	2	4.5	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C1CCCC1	nan
	CHEMBL3728585	135575	None	0	Human	Functional	pEC50	=	6.7	6.7	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	5	2	2	4.5	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C1CCCC1	nan
	67495712	135579	None	0	Human	Functional	pEC50	=	6.7	6.7	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	7	1	2	4.9	CCCN(CC1CC1)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728613	135579	None	0	Human	Functional	pEC50	=	6.7	6.7	14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	7	1	2	4.9	CCCN(CC1CC1)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	145953127	162534	None	0	Human	Functional	pEC50	=	5.7	5.7	9	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	470	8	4	2	4.9	O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4166447	162534	None	0	Human	Functional	pEC50	=	5.7	5.7	9	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	470	8	4	2	4.9	O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	89684996	135536	None	0	Human	Functional	pEC50	=	6.7	6.7	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	557	5	2	4	5.0	CC(C)(C)OC(=O)N1CCC(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3728389	135536	None	0	Human	Functional	pEC50	=	6.7	6.7	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	557	5	2	4	5.0	CC(C)(C)OC(=O)N1CCC(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	1022	1669	None	42	Human	Functional	pEC50	=	4.7	4.7	-5128	4	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	443295	1669	None	42	Human	Functional	pEC50	=	4.7	4.7	-5128	4	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	CHEMBL267179	1669	None	42	Human	Functional	pEC50	=	4.7	4.7	-5128	4	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL		None	None	None		None	10.1021/jm900592h
	67495715	135742	None	0	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1cccc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729633	135742	None	0	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1cccc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495856	136200	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CN3CCCC3)CC1)C21CC1	nan
	CHEMBL3732371	136200	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	525	6	2	3	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CN3CCCC3)CC1)C21CC1	nan
	67495495	135400	None	0	Human	Functional	pEC50	=	7.7	7.7	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	10	2	5	3.1	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	CHEMBL3727620	135400	None	0	Human	Functional	pEC50	=	7.7	7.7	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	10	2	5	3.1	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	67495271	135849	None	0	Human	Functional	pEC50	=	7.7	7.7	398	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	7	3	3	3.7	CC(C)C[C@@H](CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730283	135849	None	0	Human	Functional	pEC50	=	7.7	7.7	398	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	7	3	3	3.7	CC(C)C[C@@H](CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	57378083	151339	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	476	6	2	9	3.8	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(C(F)(F)F)c2)o1	nan
	CHEMBL3960228	151339	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	476	6	2	9	3.8	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(C(F)(F)F)c2)o1	nan
	11262	382	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2	10.1016/j.bmc.2014.12.007
	122181321	382	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2	10.1016/j.bmc.2014.12.007
	CHEMBL3590072	382	None	0	Mouse	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2	10.1016/j.bmc.2014.12.007
	44236326	197778	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	197778	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44236326	197778	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	197778	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	67495690	135433	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	9	2	5	3.3	O=C(NCc1cnc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727792	135433	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	9	2	5	3.3	O=C(NCc1cnc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495155	135903	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	514	8	2	4	2.6	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3730632	135903	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	514	8	2	4	2.6	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496425	135530	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	532	8	3	3	4.5	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	CHEMBL3728352	135530	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	532	8	3	3	4.5	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	67495953	135805	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	4	2	2	4.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCCC1)C21CC1	nan
	CHEMBL3730033	135805	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	4	2	2	4.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCCC1)C21CC1	nan
	CHEMBL5090603	217764	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC(CN2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2021.113805
	89685004	135852	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	4	2	4	4.7	CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3730306	135852	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	4	2	4	4.7	CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	87422027	135434	None	0	Human	Functional	pEC50	=	7.7	7.7	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	494	8	2	5	3.9	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727795	135434	None	0	Human	Functional	pEC50	=	7.7	7.7	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	494	8	2	5	3.9	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496050	135783	None	0	Human	Functional	pEC50	=	7.7	7.7	42	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	9	3	3	3.5	NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3729885	135783	None	0	Human	Functional	pEC50	=	7.7	7.7	42	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	9	3	3	3.5	NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1	nan
	67495190	136292	None	0	Human	Functional	pEC50	=	7.7	7.7	67	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	6	2	4	2.9	COC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732895	136292	None	0	Human	Functional	pEC50	=	7.7	7.7	67	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	6	2	4	2.9	COC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	168288195	191871	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)no2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5197701	191871	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)no2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67495923	135568	None	0	Human	Functional	pEC50	=	6.7	6.7	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	7	3	3	3.4	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728553	135568	None	0	Human	Functional	pEC50	=	6.7	6.7	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	7	3	3	3.4	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495196	135675	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	5	3.4	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL3729225	135675	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	5	3.4	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL5085435	217456	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCN(Cc3ccccc3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	87421992	135935	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	8	2	5	4.1	O=C(Nc1nc2ccccc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730819	135935	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	8	2	5	4.1	O=C(Nc1nc2ccccc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44413534	138466	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	4	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2006.04.068
	CHEMBL377226	138466	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	4	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2006.04.068
	67495918	135558	None	0	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	4	3.6	CC(=O)c1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728508	135558	None	0	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	4	3.6	CC(=O)c1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67495331	135567	None	0	Human	Functional	pEC50	=	7.6	7.6	120	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	5	3	3	2.8	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	CHEMBL3728546	135567	None	0	Human	Functional	pEC50	=	7.6	7.6	120	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	5	3	3	2.8	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	67495564	136347	None	0	Human	Functional	pEC50	=	7.6	7.6	100	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	7	3	4	3.2	NS(=O)(=O)c1ccc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL3733264	136347	None	0	Human	Functional	pEC50	=	7.6	7.6	100	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	7	3	4	3.2	NS(=O)(=O)c1ccc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL5075000	216841	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCNCC2)C1=O	10.1016/j.ejmech.2021.113805
	122181232	121913	None	0	Human	Functional	pEC50	=	6.6	6.6	8	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589946	121913	None	0	Human	Functional	pEC50	=	6.6	6.6	8	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181234	121915	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589948	121915	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181324	121931	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590075	121931	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-2	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168295570	192313	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	378	3	2	4	2.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3nc(Cl)ccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5204594	192313	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	378	3	2	4	2.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3nc(Cl)ccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	168274924	190378	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5175543	190378	None	0	Human	Functional	pEC50	=	5.6	5.6	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5080179	217155	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	67496353	135929	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730781	135929	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495785	135369	None	0	Human	Functional	pEC50	=	7.6	7.6	223	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	9	1	4	3.3	COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727426	135369	None	0	Human	Functional	pEC50	=	7.6	7.6	223	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	9	1	4	3.3	COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422136	135602	None	0	Human	Functional	pEC50	=	7.6	7.6	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	390	6	3	4	1.7	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Cl)nc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3728771	135602	None	0	Human	Functional	pEC50	=	7.6	7.6	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	390	6	3	4	1.7	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Cl)nc2)[C@@H]2CC[C@H]1C21CC1	nan
	67495409	135650	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729082	135650	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496020	135947	None	0	Human	Functional	pEC50	=	7.6	7.6	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.1	CCn1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1C	nan
	CHEMBL3730881	135947	None	0	Human	Functional	pEC50	=	7.6	7.6	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.1	CCn1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1C	nan
	87422334	136157	None	0	Human	Functional	pEC50	=	7.6	7.6	181	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	4	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	CHEMBL3732094	136157	None	0	Human	Functional	pEC50	=	7.6	7.6	181	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	4	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1	nan
	122181231	121772	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3588871	121772	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-2	3	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168286767	191791	None	0	Human	Functional	pEC50	=	6.6	6.6	53	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5196551	191791	None	0	Human	Functional	pEC50	=	6.6	6.6	53	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	67495496	135871	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	1.9	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730424	135871	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	1.9	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	44233905	198789	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	CHEMBL562380	198789	None	0	Human	Functional	pEC50	=	5.6	5.6	-1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1021/jm900592h
	44413496	139850	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	386	4	2	6	3.4	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cncnc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL379853	139850	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	386	4	2	6	3.4	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cncnc2)n1C	10.1016/j.bmcl.2006.04.068
	92881734	121972	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	463	5	2	2	4.8	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc21	10.1016/j.bmc.2015.03.062
	CHEMBL3590208	121972	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	463	5	2	2	4.8	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc21	10.1016/j.bmc.2015.03.062
	162676377	183453	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4797594	183453	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL5085435	217456	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCN(Cc3ccccc3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	162425412	191177	None	0	Human	Functional	pEC50	=	6.6	6.6	21	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	386	5	2	6	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5187399	191177	None	0	Human	Functional	pEC50	=	6.6	6.6	21	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	386	5	2	6	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	146597617	192075	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2ncc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5201015	192075	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2ncc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	168281597	191379	None	0	Human	Functional	pEC50	=	6.6	6.6	50	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5190571	191379	None	0	Human	Functional	pEC50	=	6.6	6.6	50	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	122181318	121926	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590069	121926	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181325	121932	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590076	121932	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145952485	162948	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172968	162948	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	168288891	191675	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2noc(-c3ccc(Cl)cc3)n2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5194850	191675	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2noc(-c3ccc(Cl)cc3)n2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67496417	136083	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	4	4.3	Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cs1	nan
	CHEMBL3731676	136083	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	4	4.3	Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cs1	nan
	127036712	136359	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	7	3	4	1.3	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cn2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733330	136359	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	7	3	4	1.3	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cn2)[C@@H]2C=C[C@H]1C21CC1	nan
	164916036	191696	None	0	Human	Functional	pEC50	=	7.6	7.6	147	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5195186	191696	None	0	Human	Functional	pEC50	=	7.6	7.6	147	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	67495766	135617	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	7	3	3	3.0	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728857	135617	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	7	3	3	3.0	CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495515	136350	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	5	3	3	2.2	C[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(N)=O	nan
	CHEMBL3733280	136350	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	5	3	3	2.2	C[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(N)=O	nan
	122181319	121927	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590070	121927	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	67496719	136387	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	10	2	4	3.8	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl	nan
	CHEMBL3728133	136387	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	10	2	4	3.8	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl	nan
	CHEMBL3733972	136387	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	10	2	4	3.8	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl	nan
	67495526	135671	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	4	4.3	O=C(Nc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729208	135671	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	4	4.3	O=C(Nc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495947	135651	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	2	3	2.9	CN(C)CC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729083	135651	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	6	2	3	2.9	CN(C)CC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496240	136066	None	0	Human	Functional	pEC50	=	7.6	7.6	81	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	545	9	3	4	5.0	CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731561	136066	None	0	Human	Functional	pEC50	=	7.6	7.6	81	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	545	9	3	4	5.0	CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181320	121928	None	0	Human	Functional	pEC50	=	6.6	6.6	5	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590071	121928	None	0	Human	Functional	pEC50	=	6.6	6.6	5	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL5084374	217400	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCNCC2)C1=O	10.1016/j.ejmech.2021.113805
	168279295	191155	None	0	Human	Functional	pEC50	=	6.6	6.6	91	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187135	191155	None	0	Human	Functional	pEC50	=	6.6	6.6	91	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	24776357	94249	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	386	4	1	3	4.7	CCc1ccc2[nH]c(C(=O)N3CC[C@@H](n4c(CC)nc5ccccc54)C3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL249742	94249	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	386	4	1	3	4.7	CCc1ccc2[nH]c(C(=O)N3CC[C@@H](n4c(CC)nc5ccccc54)C3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL5085818	217480	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O	10.1016/j.ejmech.2021.113805
	24776349	155079	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	450	4	1	4	5.7	COc1ccc2[nH]c(C(=O)N3CCC(n4c(-c5ccccc5)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL401313	155079	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	450	4	1	4	5.7	COc1ccc2[nH]c(C(=O)N3CCC(n4c(-c5ccccc5)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	162668376	182597	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	407	5	4	5	1.7	O=C(Nc1ccc(Br)cc1)NC1(C(=O)NCc2nn[nH]n2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4786842	182597	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	407	5	4	5	1.7	O=C(Nc1ccc(Br)cc1)NC1(C(=O)NCc2nn[nH]n2)CCCC1	10.1016/j.ejmech.2021.113194
	71699063	90734	None	0	Human	Functional	pEC50	=	4.6	4.6	1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	454	6	2	5	2.6	Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391440	90734	None	0	Human	Functional	pEC50	=	4.6	4.6	1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	454	6	2	5	2.6	Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	67496228	135704	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	8	3	6	1.3	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN)C32CC2)n1	nan
	CHEMBL3729427	135704	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	8	3	6	1.3	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN)C32CC2)n1	nan
	5308652	138737	None	2	Human	Functional	pEC50	=	5.6	5.6	1	2	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	352	4	2	5	3.1	COc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL377642	138737	None	2	Human	Functional	pEC50	=	5.6	5.6	1	2	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	352	4	2	5	3.1	COc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	67496454	135864	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.5	Cc1cc(Br)ccc1NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730378	135864	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	4.5	Cc1cc(Br)ccc1NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495449	135691	None	0	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729342	135691	None	0	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495561	136302	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	453	10	2	5	2.9	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	CHEMBL3732960	136302	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	453	10	2	5	2.9	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	CHEMBL5076199	216908	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		Cc1nn(-c2ccccc2)c(C)c1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O	10.1016/j.ejmech.2021.113805
	71699062	90732	None	0	Human	Functional	pEC50	=	5.6	5.6	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	412	5	1	5	2.9	Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391439	90732	None	0	Human	Functional	pEC50	=	5.6	5.6	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	412	5	1	5	2.9	Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	71699143	90742	None	0	Human	Functional	pEC50	=	5.6	5.6	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	470	6	2	6	3.2	COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391450	90742	None	0	Human	Functional	pEC50	=	5.6	5.6	3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	470	6	2	6	3.2	COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	122181322	121929	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-4	3	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590073	121929	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-4	3	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL5070452	216725	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	67495297	136316	None	0	Human	Functional	pEC50	=	6.5	6.5	52	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	9	2	6	1.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN(C)C)C32CC2)n1	nan
	CHEMBL3733076	136316	None	0	Human	Functional	pEC50	=	6.5	6.5	52	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	9	2	6	1.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN(C)C)C32CC2)n1	nan
	67495865	135378	None	0	Human	Functional	pEC50	=	6.5	6.5	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	2	3	2.6	CN(C)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727453	135378	None	0	Human	Functional	pEC50	=	6.5	6.5	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	2	3	2.6	CN(C)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495510	136372	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F	nan
	CHEMBL3733253	136372	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F	nan
	CHEMBL3733939	136372	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F	nan
	145949892	162915	None	0	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172556	162915	None	0	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	67495961	136399	None	0	Human	Functional	pEC50	=	5.5	5.5	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.5	CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3730203	136399	None	0	Human	Functional	pEC50	=	5.5	5.5	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.5	CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3733983	136399	None	0	Human	Functional	pEC50	=	5.5	5.5	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.5	CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	71698442	90739	None	0	Human	Functional	pEC50	=	4.5	4.5	-3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	336	3	2	5	1.5	Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391448	90739	None	0	Human	Functional	pEC50	=	4.5	4.5	-3	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	336	3	2	5	1.5	Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	67495965	135764	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	8	3	6	0.8	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)n1	nan
	CHEMBL3729761	135764	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	8	3	6	0.8	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)n1	nan
	67495646	136238	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	512	6	1	2	5.6	CN(C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)Cc1ccccc1Cl	nan
	CHEMBL3732583	136238	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	512	6	1	2	5.6	CN(C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)Cc1ccccc1Cl	nan
	67495824	135857	None	0	Human	Functional	pEC50	=	8.5	8.5	1445	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	5	2	3	3.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1	nan
	CHEMBL3730354	135857	None	0	Human	Functional	pEC50	=	8.5	8.5	1445	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	5	2	3	3.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1	nan
	67496189	135940	None	0	Human	Functional	pEC50	=	8.5	8.5	371	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	3	3	2.5	CNC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730852	135940	None	0	Human	Functional	pEC50	=	8.5	8.5	371	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	6	3	3	2.5	CNC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	127024133	135599	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	5	3	3	3.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCC(O)CC1)C21CC1	nan
	CHEMBL3728753	135599	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	5	3	3	3.9	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCC(O)CC1)C21CC1	nan
	67495181	135446	None	0	Human	Functional	pEC50	=	8.5	8.5	616	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	6	2	3	2.8	CN(C)C(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727840	135446	None	0	Human	Functional	pEC50	=	8.5	8.5	616	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	6	2	3	2.8	CN(C)C(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495807	135848	None	0	Human	Functional	pEC50	=	8.4	8.4	1122	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	7	2	3	4.1	CCSCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730279	135848	None	0	Human	Functional	pEC50	=	8.4	8.4	1122	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	7	2	3	4.1	CCSCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	127035356	135571	None	0	Human	Functional	pEC50	=	8.4	8.4	2137	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	6	2	4	3.1	CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728562	135571	None	0	Human	Functional	pEC50	=	8.4	8.4	2137	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	6	2	4	3.1	CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495379	136148	None	0	Human	Functional	pEC50	=	8.4	8.4	93	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	10	2	3	4.8	CCN(CC)CCCC(C)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732049	136148	None	0	Human	Functional	pEC50	=	8.4	8.4	93	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	501	10	2	3	4.8	CCN(CC)CCCC(C)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	16036926	77689	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	448	3	2	4	3.7	Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL208884	77689	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	448	3	2	4	3.7	Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	44413525	139715	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	447	5	2	6	5.2	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL379762	139715	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	447	5	2	6	5.2	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	162645814	179742	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	404	6	3	3	4.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4742937	179742	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	404	6	3	3	4.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	67495531	136360	None	0	Human	Functional	pEC50	=	7.5	7.5	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	8	3	3	3.5	NCCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1	nan
	CHEMBL3733340	136360	None	0	Human	Functional	pEC50	=	7.5	7.5	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	8	3	3	3.5	NCCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1	nan
	122180578	121796	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	555	7	4	5	3.8	CNOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1C	10.1016/j.bmc.2015.03.062
	CHEMBL3588924	121796	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	555	7	4	5	3.8	CNOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1C	10.1016/j.bmc.2015.03.062
	122180579	121800	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	397	6	2	3	4.2	CSc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3588928	121800	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	397	6	2	3	4.2	CSc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL5076914	216957	None	4	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O	10.1016/j.ejmech.2021.113805
	145951856	162986	None	0	Human	Functional	pEC50	=	6.5	6.5	8	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4173645	162986	None	0	Human	Functional	pEC50	=	6.5	6.5	8	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	872695	19050	None	8	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	270	5	2	2	3.1	COc1ccc(CCNC(=O)Nc2ccccc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL1288648	19050	None	8	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	270	5	2	2	3.1	COc1ccc(CCNC(=O)Nc2ccccc2)cc1	10.1016/j.bmc.2015.03.062
	145955803	162741	None	0	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	CHEMBL4169807	162741	None	0	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	488	8	3	3	4.7	Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F	10.1016/j.ejmech.2017.09.023
	67496358	136086	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731680	136086	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495154	136254	None	0	Human	Functional	pEC50	=	6.5	6.5	29	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	5	1	4	4.0	Cc1cc(C(=O)N(C)C[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C	nan
	CHEMBL3732650	136254	None	0	Human	Functional	pEC50	=	6.5	6.5	29	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	5	1	4	4.0	Cc1cc(C(=O)N(C)C[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C	nan
	87422008	135424	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	7	2	5	3.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	CHEMBL3727729	135424	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	7	2	5	3.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	67496616	135834	None	0	Human	Functional	pEC50	=	7.5	7.5	95	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	3	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(=O)N1CCCC1)C21CC1	nan
	CHEMBL3730211	135834	None	0	Human	Functional	pEC50	=	7.5	7.5	95	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	6	2	3	3.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(=O)N1CCCC1)C21CC1	nan
	127036714	136172	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	7	3	4	1.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Cl)nc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732192	136172	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	7	3	4	1.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Cl)nc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495716	136375	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	9	2	3	3.8	O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728125	136375	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	9	2	3	3.8	O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733942	136375	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	455	9	2	3	3.8	O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44413547	79858	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	368	4	2	4	3.8	CCc1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL212113	79858	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	368	4	2	4	3.8	CCc1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	122181323	121930	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590074	121930	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168283359	190921	None	0	Human	Functional	pEC50	=	5.5	5.5	5	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5183856	190921	None	0	Human	Functional	pEC50	=	5.5	5.5	5	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	67495617	135578	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	6	2	2	4.1	O=C(CC1CC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728604	135578	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	6	2	2	4.1	O=C(CC1CC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495528	135494	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	451	11	2	4	3.0	O=C(NCCOc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728166	135494	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	451	11	2	4	3.0	O=C(NCCOc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	146597625	191371	None	2	Human	Functional	pEC50	=	7.5	7.5	47	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5190385	191371	None	2	Human	Functional	pEC50	=	7.5	7.5	47	2	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67496311	135556	None	0	Human	Functional	pEC50	=	7.5	7.5	45	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	383	7	3	4	1.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1	nan
	CHEMBL3728506	135556	None	0	Human	Functional	pEC50	=	7.5	7.5	45	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	383	7	3	4	1.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1	nan
	67495168	135757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729722	135757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	57378196	144513	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	492	7	2	10	3.7	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(OC(F)(F)F)c2)o1	nan
	CHEMBL3906325	144513	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	492	7	2	10	3.7	Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(OC(F)(F)F)c2)o1	nan
	2165902	121975	None	9	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	341	6	2	4	3.9	CCc1ccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590211	121975	None	9	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	341	6	2	4	3.9	CCc1ccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)cc1	10.1016/j.bmc.2015.03.062
	67495032	136016	None	0	Human	Functional	pEC50	=	5.5	5.5	-14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cs1	nan
	CHEMBL3731244	136016	None	0	Human	Functional	pEC50	=	5.5	5.5	-14	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cs1	nan
	CHEMBL5084374	217400	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCNCC2)C1=O	10.1016/j.ejmech.2021.113805
	67495652	136351	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	505	9	2	4	3.9	O=C(NCc1csc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733287	136351	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	505	9	2	4	3.9	O=C(NCc1csc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	145956361	162105	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4159569	162105	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	67496430	135765	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	368	6	3	4	1.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)nc1	nan
	CHEMBL3729765	135765	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	368	6	3	4	1.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)nc1	nan
	87422315	135419	None	0	Human	Functional	pEC50	=	6.5	6.5	45	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	441	5	3	5	2.8	CC(C)(CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3727702	135419	None	0	Human	Functional	pEC50	=	6.5	6.5	45	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	441	5	3	5	2.8	CC(C)(CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	67495430	135410	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	532	7	2	4	4.9	Cn1c(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nc2ccccc21	nan
	CHEMBL3727668	135410	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	532	7	2	4	4.9	Cn1c(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nc2ccccc21	nan
	67495295	135838	None	0	Human	Functional	pEC50	=	7.5	7.5	66	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	8	2	3	3.7	CCN(CC)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730231	135838	None	0	Human	Functional	pEC50	=	7.5	7.5	66	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	459	8	2	3	3.7	CCN(CC)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495822	135957	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	7	2	2	4.5	CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730944	135957	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	430	7	2	2	4.5	CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	24776351	94149	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL249132	94149	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	168280238	191063	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185921	191063	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	145956361	162105	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4159569	162105	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	87422107	136404	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	8	2	4	4.0	O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729273	136404	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	8	2	4	4.0	O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733988	136404	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	8	2	4	4.0	O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL5070452	216725	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	67496611	135787	None	0	Human	Functional	pEC50	=	6.5	6.5	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	2.2	CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729916	135787	None	0	Human	Functional	pEC50	=	6.5	6.5	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	2.2	CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	168284711	191711	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc(-c3ccc(Cl)cc3)no2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5195336	191711	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc(-c3ccc(Cl)cc3)no2)c(F)c1	10.1021/acsmedchemlett.2c00079
	24776352	155080	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1[C@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL401314	155080	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	388	4	1	4	4.2	CCc1nc2ccccc2n1[C@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	67496253	136011	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	401	10	2	3	3.0	CC(C)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731214	136011	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	401	10	2	3	3.0	CC(C)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87422039	135485	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	413	5	2	4	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	CHEMBL3728109	135485	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	413	5	2	4	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	67495594	135533	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	387	10	2	3	2.7	CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728370	135533	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	387	10	2	3	2.7	CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495485	136246	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	8	2	5	3.7	CC(C)(C)c1cc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	CHEMBL3732612	136246	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	8	2	5	3.7	CC(C)(C)c1cc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	162653376	180491	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	403	4	3	4	3.3	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4751781	180491	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	403	4	3	4	3.3	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1	10.1016/j.ejmech.2021.113194
	67495890	135544	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	493	7	3	3	3.7	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL3728437	135544	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	493	7	3	3	3.7	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	67495438	136232	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	519	8	2	3	4.9	O=C(Nc1ccc(Br)c(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732539	136232	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	519	8	2	3	4.9	O=C(Nc1ccc(Br)c(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162644626	179498	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	436	5	3	3	3.3	CN1CCC(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)CC1	10.1016/j.ejmech.2021.113194
	CHEMBL4739874	179498	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	436	5	3	3	3.3	CN1CCC(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)CC1	10.1016/j.ejmech.2021.113194
	127035355	136038	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	385	7	2	5	2.1	CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC(C)C)C32CC2)n1	nan
	CHEMBL3731384	136038	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	385	7	2	5	2.1	CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC(C)C)C32CC2)n1	nan
	146649326	192107	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	436	5	2	6	3.8	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)s2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5201495	192107	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	436	5	2	6	3.8	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)s2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67495333	135711	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	6	2	4	5.3	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cnoc1-c1ccccc1	nan
	CHEMBL3729471	135711	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	6	2	4	5.3	O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cnoc1-c1ccccc1	nan
	CHEMBL5085818	217480	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O	10.1016/j.ejmech.2021.113805
	2215592	79859	None	7	Human	Functional	pEC50	=	5.4	5.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	347	3	2	5	3.0	Cc1c(NC(=O)Nc2ccc(C#N)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL212116	79859	None	7	Human	Functional	pEC50	=	5.4	5.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	347	3	2	5	3.0	Cc1c(NC(=O)Nc2ccc(C#N)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	168293191	192240	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	416	6	2	7	2.7	COc1ccc(-c2nnc(N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(OC)cc3F)o2)cc1	10.1021/acsmedchemlett.2c00079
	CHEMBL5203596	192240	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	416	6	2	7	2.7	COc1ccc(-c2nnc(N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(OC)cc3F)o2)cc1	10.1021/acsmedchemlett.2c00079
	127035212	135642	None	0	Human	Functional	pEC50	=	6.4	6.4	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	5	3	3	3.5	CNC(=O)[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(C)(C)C	nan
	CHEMBL3729032	135642	None	0	Human	Functional	pEC50	=	6.4	6.4	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	5	3	3	3.5	CNC(=O)[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(C)(C)C	nan
	CHEMBL5088171	217633	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2cnn(-c3ccncc3)c2)C1=O	10.1016/j.ejmech.2021.113805
	67495542	135770	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	542	8	2	4	3.3	CC(=O)N1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3729805	135770	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	542	8	2	4	3.3	CC(=O)N1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	168282231	191071	None	0	Human	Functional	pEC50	=	6.4	6.4	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185982	191071	None	0	Human	Functional	pEC50	=	6.4	6.4	16	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	44233905	198789	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2021.113194
	CHEMBL562380	198789	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay	ChEMBL	441	6	1	5	3.6	COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2021.113194
	122181319	121927	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-7	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590070	121927	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-7	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	44236326	197778	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551589	197778	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	441	6	1	5	3.6	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	67495653	135826	None	0	Human	Functional	pEC50	=	5.4	5.4	-295	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	553	8	2	3	5.2	O=C(Nc1ccc(Br)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730156	135826	None	0	Human	Functional	pEC50	=	5.4	5.4	-295	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	553	8	2	3	5.2	O=C(Nc1ccc(Br)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495892	136104	None	0	Human	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	7	3	6	1.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC2CCNCC2)C32CC2)n1	nan
	CHEMBL3731785	136104	None	0	Human	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	7	3	6	1.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC2CCNCC2)C32CC2)n1	nan
	CHEMBL5093348	217914	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(c3ncccn3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	162673364	183105	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	394	5	4	3	2.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4793549	183105	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	394	5	4	3	2.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	67495440	136373	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	4	3.3	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	CHEMBL3729027	136373	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	4	3.3	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	CHEMBL3733940	136373	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	4	3.3	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F	nan
	122181320	121928	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590071	121928	None	0	Mouse	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145958736	162310	None	0	Human	Functional	pEC50	=	5.4	5.4	6	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162930	162310	None	0	Human	Functional	pEC50	=	5.4	5.4	6	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	508	8	3	3	5.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	67495563	136393	None	0	Human	Functional	pEC50	=	5.4	5.4	-128	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	10	2	3	3.5	Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728150	136393	None	0	Human	Functional	pEC50	=	5.4	5.4	-128	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	10	2	3	3.5	Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3733978	136393	None	0	Human	Functional	pEC50	=	5.4	5.4	-128	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	10	2	3	3.5	Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67496272	135512	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	579	7	3	4	5.6	CC(C)(C)OC(=O)NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL3728252	135512	None	0	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	579	7	3	4	5.6	CC(C)(C)OC(=O)NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	122180580	121801	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	473	6	4	3	3.0	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)NN1CCCCNC1=O	10.1016/j.bmc.2015.03.062
	CHEMBL3588929	121801	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	473	6	4	3	3.0	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)NN1CCCCNC1=O	10.1016/j.bmc.2015.03.062
	67495873	135585	None	0	Human	Functional	pEC50	=	8.4	8.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	514	8	2	4	3.4	CN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3728649	135585	None	0	Human	Functional	pEC50	=	8.4	8.4	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	514	8	2	4	3.4	CN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67495579	136097	None	0	Human	Functional	pEC50	=	8.4	8.4	363	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	7	2	4	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1	nan
	CHEMBL3731739	136097	None	0	Human	Functional	pEC50	=	8.4	8.4	363	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	7	2	4	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1	nan
	67495722	135804	None	0	Human	Functional	pEC50	=	8.4	8.4	177	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	4	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1	nan
	CHEMBL3730024	135804	None	0	Human	Functional	pEC50	=	8.4	8.4	177	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	443	4	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1	nan
	67496623	136222	None	0	Human	Functional	pEC50	=	8.4	8.4	467	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	6	3	4	3.9	CC(C)(C)OC(=O)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732493	136222	None	0	Human	Functional	pEC50	=	8.4	8.4	467	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	6	3	4	3.9	CC(C)(C)OC(=O)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495493	136403	None	0	Human	Functional	pEC50	=	8.4	8.4	117	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1	nan
	CHEMBL3729299	136403	None	0	Human	Functional	pEC50	=	8.4	8.4	117	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1	nan
	CHEMBL3733987	136403	None	0	Human	Functional	pEC50	=	8.4	8.4	117	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1	nan
	127035730	135539	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	461	8	4	4	2.3	CC(CO)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728401	135539	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	461	8	4	4	2.3	CC(CO)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495138	135564	None	0	Human	Functional	pEC50	=	8.3	8.3	1445	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	434	7	2	3	3.6	COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3728536	135564	None	0	Human	Functional	pEC50	=	8.3	8.3	1445	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	434	7	2	3	3.6	COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1	nan
	67496172	135902	None	0	Human	Functional	pEC50	=	8.3	8.3	1174	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	6	3	3	2.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	CHEMBL3730629	135902	None	0	Human	Functional	pEC50	=	8.3	8.3	1174	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	6	3	3	2.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	67495286	136025	None	0	Human	Functional	pEC50	=	8.3	8.3	83	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	7	2	3	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	CHEMBL3731297	136025	None	0	Human	Functional	pEC50	=	8.3	8.3	83	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	7	2	3	3.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	11418989	121798	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	429	5	2	2	4.2	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1	10.1016/j.bmc.2015.03.062
	CHEMBL3588926	121798	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	429	5	2	2	4.2	O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1	10.1016/j.bmc.2015.03.062
	168272852	190772	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	402	5	2	6	3.2	COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5181627	190772	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	402	5	2	6	3.2	COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	168282219	191057	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	378	3	2	4	2.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)cnc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5185842	191057	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	378	3	2	4	2.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)cnc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	67495368	136194	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732345	136194	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495210	136384	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	426	9	2	5	2.4	Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	CHEMBL3730873	136384	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	426	9	2	5	2.4	Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	CHEMBL3733951	136384	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	426	9	2	5	2.4	Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	6268	310	None	3	Human	Functional	pEC50	=	6.4	6.4	2	3	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1016/j.bmc.2015.03.062
	727787	310	None	3	Human	Functional	pEC50	=	6.4	6.4	2	3	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1016/j.bmc.2015.03.062
	CHEMBL1289260	310	None	3	Human	Functional	pEC50	=	6.4	6.4	2	3	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1016/j.bmc.2015.03.062
	CHEMBL5090603	217764	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC(CN2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2021.113805
	CHEMBL5076199	216908	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		Cc1nn(-c2ccccc2)c(C)c1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O	10.1016/j.ejmech.2021.113805
	44236328	198132	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL556625	198132	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	397	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/jm900592h
	1416500	121973	None	9	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	391	5	2	4	4.1	COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Br)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL3590209	121973	None	9	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	391	5	2	4	4.1	COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Br)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL5080179	217155	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	168282160	190959	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184490	190959	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	145956762	162262	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4162303	162262	None	0	Human	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	67495622	136014	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	547	9	2	3	3.7	O=C(NCc1ccc(I)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731221	136014	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	547	9	2	3	3.7	O=C(NCc1ccc(I)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44413508	78605	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	398	5	2	7	3.5	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL211220	78605	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	398	5	2	7	3.5	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL5076914	216957	None	4	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O	10.1016/j.ejmech.2021.113805
	122181322	121929	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590073	121929	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	71698531	90707	None	0	Human	Functional	pEC50	=	5.4	5.4	2	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	4.9	COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391258	90707	None	0	Human	Functional	pEC50	=	5.4	5.4	2	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	4.9	COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	24776341	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2006.04.068
	5831	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2006.04.068
	CHEMBL379761	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2006.04.068
	44413498	140263	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	469	4	2	5	5.5	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL380389	140263	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	469	4	2	5	5.5	CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C	10.1016/j.bmcl.2006.04.068
	87422121	135415	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	6	2	5	2.4	COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727690	135415	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	6	2	5	2.4	COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	24776341	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2007.09.043
	5831	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2007.09.043
	CHEMBL379761	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1016/j.bmcl.2007.09.043
	127037326	136084	None	0	Human	Functional	pEC50	=	5.4	5.4	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	8	2	5	4.4	Cc1nsc2cc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)ccc12	nan
	CHEMBL3731677	136084	None	0	Human	Functional	pEC50	=	5.4	5.4	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	8	2	5	4.4	Cc1nsc2cc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)ccc12	nan
	87422278	135665	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	6	3	5	3.4	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL3729184	135665	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	486	6	3	5	3.4	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	122181322	121929	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590073	121929	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168279956	191192	None	0	Human	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187563	191192	None	0	Human	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	44232675	198119	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	CHEMBL556485	198119	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	44232675	198119	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	CHEMBL556485	198119	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	407	6	1	7	2.5	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1	10.1021/jm900592h
	67495000	135499	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	435	9	2	3	3.4	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728190	135499	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	435	9	2	3	3.4	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67495216	135959	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730955	135959	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	535	9	2	3	4.2	O=C(NCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87422168	135395	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	8	2	5	3.2	Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL3727588	135395	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	8	2	5	3.2	Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	127037112	136031	None	0	Human	Functional	pEC50	=	6.3	6.3	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	7	3	2	5.4	O=C(CCc1cc2ccccc2[nH]1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731359	136031	None	0	Human	Functional	pEC50	=	6.3	6.3	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	7	3	2	5.4	O=C(CCc1cc2ccccc2[nH]1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422233	135500	None	0	Human	Functional	pEC50	=	6.3	6.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	540	8	3	6	4.3	CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3728194	135500	None	0	Human	Functional	pEC50	=	6.3	6.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	540	8	3	6	4.3	CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	67495168	135757	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729722	135757	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	9	2	3	3.9	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495643	136044	None	0	Human	Functional	pEC50	=	7.3	7.3	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	3.7	O=C(CCCN1CCCC1=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731426	136044	None	0	Human	Functional	pEC50	=	7.3	7.3	169	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	8	2	3	3.7	O=C(CCCN1CCCC1=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181412	121981	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay	ChEMBL	431	8	2	5	5.1	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590217	121981	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay	ChEMBL	431	8	2	5	5.1	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1	10.1016/j.bmc.2015.03.062
	2302157	19343	None	6	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	373	7	2	6	3.3	COc1ccc2[nH]c(SCC(=O)Nc3ccc(OC)c(OC)c3)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL1290698	19343	None	6	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	373	7	2	6	3.3	COc1ccc2[nH]c(SCC(=O)Nc3ccc(OC)c(OC)c3)nc2c1	10.1016/j.bmc.2015.03.062
	67496188	136181	None	0	Human	Functional	pEC50	=	5.3	5.3	-23	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	3.9	O=C(NCc1cccc(Cl)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732252	136181	None	0	Human	Functional	pEC50	=	5.3	5.3	-23	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	3.9	O=C(NCc1cccc(Cl)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495059	135525	None	0	Human	Functional	pEC50	=	6.3	6.3	47	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	9	2	7	1.5	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCN(C)CC2)C32CC2)n1	nan
	CHEMBL3728337	135525	None	0	Human	Functional	pEC50	=	6.3	6.3	47	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	9	2	7	1.5	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCN(C)CC2)C32CC2)n1	nan
	89684994	135986	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	515	4	2	4	4.0	CC(C)(C)OC(=O)N1CC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	CHEMBL3731092	135986	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	515	4	2	4	4.0	CC(C)(C)OC(=O)N1CC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	162654865	180681	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	433	5	3	4	3.8	Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4754119	180681	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	433	5	3	4	3.8	Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	310357	139230	None	13	Human	Functional	pEC50	=	5.3	5.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	340	3	2	4	3.3	Cc1c(NC(=O)Nc2ccc(F)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL378707	139230	None	13	Human	Functional	pEC50	=	5.3	5.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	340	3	2	4	3.3	Cc1c(NC(=O)Nc2ccc(F)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL5078594	217056	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay	ChEMBL		None	None	None		Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O	10.1016/j.ejmech.2021.113805
	87422158	135886	None	0	Human	Functional	pEC50	=	7.3	7.3	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	7	2	6	2.4	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3730506	135886	None	0	Human	Functional	pEC50	=	7.3	7.3	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	7	2	6	2.4	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67495439	135910	None	0	Human	Functional	pEC50	=	7.3	7.3	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	3.5	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	CHEMBL3730671	135910	None	0	Human	Functional	pEC50	=	7.3	7.3	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	485	8	2	3	3.5	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1	nan
	1367800	78146	None	24	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	356	3	2	4	3.8	Cc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL210298	78146	None	24	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	356	3	2	4	3.8	Cc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	122181323	121930	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590074	121930	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181232	121913	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-8	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589946	121913	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-8	2	Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	67496566	136383	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	8	2	5	3.6	O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728646	136383	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	8	2	5	3.6	O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733950	136383	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	8	2	5	3.6	O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	11024	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	11024	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	122583088	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	CHEMBL4784510	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	67496890	136039	None	0	Human	Functional	pEC50	=	8.3	8.3	281	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	6	2	3	3.0	COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731396	136039	None	0	Human	Functional	pEC50	=	8.3	8.3	281	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	418	6	2	3	3.0	COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495869	136401	None	0	Human	Functional	pEC50	=	8.3	8.3	954	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.2	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1	nan
	CHEMBL3732090	136401	None	0	Human	Functional	pEC50	=	8.3	8.3	954	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.2	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1	nan
	CHEMBL3733985	136401	None	0	Human	Functional	pEC50	=	8.3	8.3	954	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	8	2	3	4.2	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1	nan
	127035056	136026	None	0	Human	Functional	pEC50	=	8.3	8.3	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	477	8	2	3	4.7	O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731308	136026	None	0	Human	Functional	pEC50	=	8.3	8.3	19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	477	8	2	3	4.7	O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496357	136278	None	0	Human	Functional	pEC50	=	8.3	8.3	616	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	518	7	3	3	4.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	CHEMBL3732803	136278	None	0	Human	Functional	pEC50	=	8.3	8.3	616	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	518	7	3	3	4.8	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1	nan
	87421957	135961	None	0	Human	Functional	pEC50	=	8.2	8.2	269	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	5	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	CHEMBL3730960	135961	None	0	Human	Functional	pEC50	=	8.2	8.2	269	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	464	5	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	67496595	135725	None	0	Human	Functional	pEC50	=	8.2	8.2	707	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	2	3	3.8	CN1CCCC1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729542	135725	None	0	Human	Functional	pEC50	=	8.2	8.2	707	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	2	3	3.8	CN1CCCC1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422137	136110	None	0	Human	Functional	pEC50	=	8.2	8.2	1047	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	6	3	4	1.6	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)nc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731817	136110	None	0	Human	Functional	pEC50	=	8.2	8.2	1047	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	6	3	4	1.6	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)nc2)[C@@H]2C=C[C@H]1C21CC1	nan
	93095549	121799	None	5	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	385	5	2	2	4.1	O=C(Nc1ccc(Cl)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1	10.1016/j.bmc.2015.03.062
	CHEMBL3588927	121799	None	5	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	385	5	2	2	4.1	O=C(Nc1ccc(Cl)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1	10.1016/j.bmc.2015.03.062
	67495885	135577	None	0	Human	Functional	pEC50	=	6.3	6.3	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	6	2	2	4.1	CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728603	135577	None	0	Human	Functional	pEC50	=	6.3	6.3	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	6	2	2	4.1	CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	57377976	151189	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	412	6	2	9	2.6	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccc(F)cc3)n2)n1	nan
	CHEMBL3959136	151189	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	412	6	2	9	2.6	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccc(F)cc3)n2)n1	nan
	146035588	170999	None	2	Human	Functional	pEC50	=	7.3	7.3	5	2	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4454594	170999	None	2	Human	Functional	pEC50	=	7.3	7.3	5	2	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL5085666	217468	None	5	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccc(F)cc2)C1=O	10.1016/j.ejmech.2021.113805
	24776344	94306	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	374	3	1	4	4.0	COc1ccc2[nH]c(C(=O)N3CCC(n4cnc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL250143	94306	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	374	3	1	4	4.0	COc1ccc2[nH]c(C(=O)N3CCC(n4cnc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	44413526	138453	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	405	4	2	7	3.6	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(C3=NCCS3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL377163	138453	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	405	4	2	7	3.6	CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(C3=NCCS3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	67495101	136376	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	9	2	3	3.3	O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732392	136376	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	9	2	3	3.3	O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733943	136376	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	9	2	3	3.3	O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495555	136008	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	384	7	3	4	2.1	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(=O)O)C32CC2)cc1	nan
	CHEMBL3731200	136008	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	384	7	3	4	2.1	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(=O)O)C32CC2)cc1	nan
	87422285	135493	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	554	9	3	6	4.7	CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3728159	135493	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	554	9	3	6	4.7	CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	67495416	135917	None	0	Human	Functional	pEC50	=	7.3	7.3	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	8	3	3	2.9	NCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730697	135917	None	0	Human	Functional	pEC50	=	7.3	7.3	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	8	3	3	2.9	NCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	67495407	136054	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	10	2	5	1.5	COC(=O)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731492	136054	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	10	2	5	1.5	COC(=O)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	146035589	173833	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4536334	173833	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	57378199	148262	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	448	7	2	9	3.6	Cc1cccc(-c2oc(C3CC3)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	CHEMBL3935685	148262	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	448	7	2	9	3.6	Cc1cccc(-c2oc(C3CC3)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1	nan
	168283383	190953	None	0	Human	Functional	pEC50	=	5.3	5.3	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184396	190953	None	0	Human	Functional	pEC50	=	5.3	5.3	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	67495545	135897	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	2	5.1	O=C(CCc1ccc(F)cc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730596	135897	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	2	5.1	O=C(CCc1ccc(F)cc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	146648736	191860	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	470	6	2	7	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(OC(F)(F)F)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5197524	191860	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	470	6	2	7	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(OC(F)(F)F)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	87421961	135406	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	494	10	2	5	3.9	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727646	135406	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	494	10	2	5	3.9	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496833	136178	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	3	3	3.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	CHEMBL3732223	136178	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	471	6	3	3	3.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	44413507	138418	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	393	3	2	6	3.6	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(C2=NCCS2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL377130	138418	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	393	3	2	6	3.6	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(C2=NCCS2)n1C	10.1016/j.bmcl.2006.04.068
	162658091	181158	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	423	6	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4759517	181158	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	423	6	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1	10.1016/j.ejmech.2021.113194
	44232924	197779	None	0	Human	Functional	pEC50	=	5.3	5.3	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL551590	197779	None	0	Human	Functional	pEC50	=	5.3	5.3	1	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	7	1	5	3.9	COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	67495592	136331	None	0	Human	Functional	pEC50	=	7.3	7.3	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	477	9	3	3	3.3	NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733163	136331	None	0	Human	Functional	pEC50	=	7.3	7.3	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	477	9	3	3	3.3	NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL5087410	217586	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	71698528	90704	None	0	Human	Functional	pEC50	=	5.3	5.3	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	3.6	CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391255	90704	None	0	Human	Functional	pEC50	=	5.3	5.3	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	503	7	1	5	3.6	CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1	10.1016/j.ejmech.2013.03.066
	67495725	135407	None	0	Human	Functional	pEC50	=	6.3	6.3	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	571	6	2	4	5.4	CC(C)(C)OC(=O)N1CCCC(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	CHEMBL3727655	135407	None	0	Human	Functional	pEC50	=	6.3	6.3	10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	571	6	2	4	5.4	CC(C)(C)OC(=O)N1CCCC(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1	nan
	67495540	136354	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	9	2	4	3.0	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	CHEMBL3733305	136354	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	9	2	4	3.0	Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	168292800	192171	None	0	Human	Functional	pEC50	=	5.3	5.3	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5202577	192171	None	0	Human	Functional	pEC50	=	5.3	5.3	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	87422038	135854	None	0	Human	Functional	pEC50	=	7.2	7.2	39	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	424	4	3	5	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CNC1)C21CC1	nan
	CHEMBL3730324	135854	None	0	Human	Functional	pEC50	=	7.2	7.2	39	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	424	4	3	5	2.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CNC1)C21CC1	nan
	127036326	136277	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	8	2	5	4.4	Cc1nc2ccc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)cc2s1	nan
	CHEMBL3732799	136277	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	478	8	2	5	4.4	Cc1nc2ccc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)cc2s1	nan
	67494937	135633	None	0	Human	Functional	pEC50	=	5.2	5.2	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	412	8	2	5	2.7	Cc1coc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3728965	135633	None	0	Human	Functional	pEC50	=	5.2	5.2	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	412	8	2	5	2.7	Cc1coc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	89684990	136223	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	7	2	3	4.8	CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3732502	136223	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	7	2	3	4.8	CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	2211856	77795	None	8	Human	Functional	pEC50	=	5.2	5.2	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	366	3	2	6	2.9	Cc1c(NC(=O)Nc2ccc3c(c2)OCO3)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL209102	77795	None	8	Human	Functional	pEC50	=	5.2	5.2	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	366	3	2	6	2.9	Cc1c(NC(=O)Nc2ccc3c(c2)OCO3)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	67495300	135934	None	0	Human	Functional	pEC50	=	7.2	7.2	40	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	385	7	3	4	1.7	COc1ccc(NC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1	nan
	CHEMBL3730815	135934	None	0	Human	Functional	pEC50	=	7.2	7.2	40	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	385	7	3	4	1.7	COc1ccc(NC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1	nan
	67495243	136243	None	0	Human	Functional	pEC50	=	7.2	7.2	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	493	7	3	3	3.7	NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	CHEMBL3732601	136243	None	0	Human	Functional	pEC50	=	7.2	7.2	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	493	7	3	3	3.7	NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1	nan
	67495785	135369	None	0	Human	Functional	pEC50	=	8.2	8.2	223	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	9	1	4	3.3	COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727426	135369	None	0	Human	Functional	pEC50	=	8.2	8.2	223	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	9	1	4	3.3	COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495572	135441	None	0	Human	Functional	pEC50	=	8.2	8.2	2630	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	404	5	3	3	2.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCO)C21CC1	nan
	CHEMBL3727812	135441	None	0	Human	Functional	pEC50	=	8.2	8.2	2630	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	404	5	3	3	2.3	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCO)C21CC1	nan
	67495383	135597	None	0	Human	Functional	pEC50	=	8.2	8.2	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	7	2	3	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCC(=O)N1CCCC1)C21CC1	nan
	CHEMBL3728739	135597	None	0	Human	Functional	pEC50	=	8.2	8.2	54	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	7	2	3	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCC(=O)N1CCCC1)C21CC1	nan
	87422236	135562	None	0	Human	Functional	pEC50	=	8.2	8.2	239	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	4	2	5	3.1	NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3CC[C@H]2C32CC2)CC1	nan
	CHEMBL3728521	135562	None	0	Human	Functional	pEC50	=	8.2	8.2	239	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	4	2	5	3.1	NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3CC[C@H]2C32CC2)CC1	nan
	87421986	135727	None	0	Human	Functional	pEC50	=	8.2	8.2	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729552	135727	None	0	Human	Functional	pEC50	=	8.2	8.2	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	492	8	2	5	3.7	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495518	136210	None	0	Human	Functional	pEC50	=	8.2	8.2	1148	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	5	3	3	1.8	NC(=O)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732419	136210	None	0	Human	Functional	pEC50	=	8.2	8.2	1148	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	417	5	3	3	1.8	NC(=O)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422206	135374	None	0	Human	Functional	pEC50	=	8.2	8.2	1698	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	399	4	2	3	2.9	N#CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727442	135374	None	0	Human	Functional	pEC50	=	8.2	8.2	1698	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	399	4	2	3	2.9	N#CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181231	121772	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3588871	121772	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL5087410	217586	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1	10.1016/j.ejmech.2021.113805
	67495699	135548	None	0	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	9	2	3	3.5	O=C(NCC1CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728471	135548	None	0	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	9	2	3	3.5	O=C(NCC1CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162657326	180978	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	423	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CCOCC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4757408	180978	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	423	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CCOCC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	162672626	183194	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	4	3	3	4.2	Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4794472	183194	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	416	4	3	3	4.2	Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	44233645	198641	None	0	Human	Functional	pEC50	=	6.2	6.2	5	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	CHEMBL561375	198641	None	0	Human	Functional	pEC50	=	6.2	6.2	5	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	44232925	199105	None	2	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL564392	199105	None	2	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	44233645	198641	None	0	Human	Functional	pEC50	=	6.2	6.2	5	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	CHEMBL561375	198641	None	0	Human	Functional	pEC50	=	6.2	6.2	5	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	363	6	1	5	2.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1	10.1021/jm900592h
	44232925	199105	None	2	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL564392	199105	None	2	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	455	6	1	5	4.1	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1021/jm900592h
	1131797	121974	None	13	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	355	6	2	5	3.5	COc1ccc2[nH]c(SCC(=O)Nc3ccc(C(C)=O)cc3)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL3590210	121974	None	13	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	355	6	2	5	3.5	COc1ccc2[nH]c(SCC(=O)Nc3ccc(C(C)=O)cc3)nc2c1	10.1016/j.bmc.2015.03.062
	67495159	136386	None	0	Human	Functional	pEC50	=	5.2	5.2	-36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	483	8	2	6	3.3	O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730534	136386	None	0	Human	Functional	pEC50	=	5.2	5.2	-36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	483	8	2	6	3.3	O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733953	136386	None	0	Human	Functional	pEC50	=	5.2	5.2	-36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	483	8	2	6	3.3	O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162652531	180514	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccccn2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4752145	180514	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccccn2)CCCC1	10.1016/j.ejmech.2021.113194
	87422208	135736	None	0	Human	Functional	pEC50	=	7.2	7.2	32	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	7	2	5	2.7	CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729600	135736	None	0	Human	Functional	pEC50	=	7.2	7.2	32	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	7	2	5	2.7	CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422124	135908	None	0	Human	Functional	pEC50	=	7.2	7.2	104	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.6	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CO)CC1)C21CC1	nan
	CHEMBL3730665	135908	None	0	Human	Functional	pEC50	=	7.2	7.2	104	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.6	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CO)CC1)C21CC1	nan
	67495691	136015	None	0	Human	Functional	pEC50	=	7.2	7.2	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	498	6	2	2	5.2	O=C(Cc1ccccc1Cl)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731223	136015	None	0	Human	Functional	pEC50	=	7.2	7.2	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	498	6	2	2	5.2	O=C(Cc1ccccc1Cl)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495560	136286	None	0	Human	Functional	pEC50	=	7.2	7.2	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	6	2	3	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCc1ccccn1)C21CC1	nan
	CHEMBL3732870	136286	None	0	Human	Functional	pEC50	=	7.2	7.2	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	6	2	3	4.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCc1ccccn1)C21CC1	nan
	162656471	180942	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	395	5	3	3	2.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1COC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4757032	180942	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	395	5	3	3	2.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1COC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	122181323	121930	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590074	121930	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	168281748	190994	None	0	Human	Functional	pEC50	=	6.2	6.2	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184913	190994	None	0	Human	Functional	pEC50	=	6.2	6.2	6	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	67496239	135901	None	0	Human	Functional	pEC50	=	7.2	7.2	72	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	400	4	2	2	3.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CC1)C21CC1	nan
	CHEMBL3730609	135901	None	0	Human	Functional	pEC50	=	7.2	7.2	72	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	400	4	2	2	3.5	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CC1)C21CC1	nan
	67495876	136244	None	0	Human	Functional	pEC50	=	7.2	7.2	87	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	545	7	3	4	4.9	CC(C)(CNC(=O)OC(C)(C)C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732602	136244	None	0	Human	Functional	pEC50	=	7.2	7.2	87	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	545	7	3	4	4.9	CC(C)(CNC(=O)OC(C)(C)C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	145952485	162948	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4172968	162948	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	483	9	3	5	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	71698972	90712	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	401	5	1	5	3.1	Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391285	90712	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	401	5	1	5	3.1	Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1	10.1016/j.ejmech.2013.03.066
	CHEMBL5087710	217604	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2021.113805
	67496888	136168	None	0	Human	Functional	pEC50	=	5.2	5.2	-67	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1cnc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL3732163	136168	None	0	Human	Functional	pEC50	=	5.2	5.2	-67	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1cnc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	67496605	136394	None	0	Human	Functional	pEC50	=	5.2	5.2	-120	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	453	10	2	3	3.3	O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732978	136394	None	0	Human	Functional	pEC50	=	5.2	5.2	-120	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	453	10	2	3	3.3	O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733979	136394	None	0	Human	Functional	pEC50	=	5.2	5.2	-120	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	453	10	2	3	3.3	O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	122181231	121772	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3588871	121772	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145963525	162417	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4164673	162417	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	67496231	135581	None	0	Human	Functional	pEC50	=	7.2	7.2	18	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	8	2	6	1.5	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN(C)C)C32CC2)n1	nan
	CHEMBL3728633	135581	None	0	Human	Functional	pEC50	=	7.2	7.2	18	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	8	2	6	1.5	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN(C)C)C32CC2)n1	nan
	145958696	162248	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4161946	162248	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	482	9	4	3	4.8	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	122181233	121914	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589947	121914	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	543	9	4	4	5.5	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	145978177	163156	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4176353	163156	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	452	8	4	2	4.7	O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	67495182	135622	None	0	Human	Functional	pEC50	=	5.2	5.2	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	4	3.6	CC(=O)c1cccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	CHEMBL3728870	135622	None	0	Human	Functional	pEC50	=	5.2	5.2	-7	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	4	3.6	CC(=O)c1cccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	87422170	136385	None	0	Human	Functional	pEC50	=	5.2	5.2	-19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	8	2	5	3.2	Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3730618	136385	None	0	Human	Functional	pEC50	=	5.2	5.2	-19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	8	2	5	3.2	Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3733952	136385	None	0	Human	Functional	pEC50	=	5.2	5.2	-19	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	428	8	2	5	3.2	Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	87422375	136175	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	420	6	2	2	3.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	CHEMBL3732201	136175	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	420	6	2	2	3.0	O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1	nan
	67496832	136379	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	9	2	5	2.8	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	CHEMBL3728237	136379	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	9	2	5	2.8	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	CHEMBL3733946	136379	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	9	2	5	2.8	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1	nan
	162663800	182022	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	6	3	3	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4779558	182022	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	402	6	3	3	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	168297721	192560	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	343	3	2	3	2.8	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3ccccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5208504	192560	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	343	3	2	3	2.8	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3ccccc3[nH]2)c(F)c1	10.1021/acsmedchemlett.2c00079
	44233644	198546	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	3	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL560780	198546	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	3	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	489	6	1	5	3.4	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1	10.1021/jm900592h
	87422214	135565	None	0	Human	Functional	pEC50	=	7.2	7.2	234	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	467	4	3	5	3.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCC(O)CC1)C21CC1	nan
	CHEMBL3728538	135565	None	0	Human	Functional	pEC50	=	7.2	7.2	234	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	467	4	3	5	3.3	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCC(O)CC1)C21CC1	nan
	24776346	94331	None	3	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	402	4	1	4	4.6	CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)CC1	10.1016/j.bmcl.2007.09.043
	CHEMBL250347	94331	None	3	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	402	4	1	4	4.6	CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)CC1	10.1016/j.bmcl.2007.09.043
	168272319	190684	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5180261	190684	None	0	Human	Functional	pEC50	=	5.2	5.2	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	67495180	136337	None	0	Human	Functional	pEC50	=	5.2	5.2	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(F)cc1Br)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733198	136337	None	0	Human	Functional	pEC50	=	5.2	5.2	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(F)cc1Br)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	127034681	136140	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	6	2	2	5.0	O=C(/C=C/c1ccccc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732009	136140	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	476	6	2	2	5.0	O=C(/C=C/c1ccccc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181408	121970	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	501	7	2	4	4.0	CCOC(=O)C1CCCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)C1	10.1016/j.bmc.2015.03.062
	CHEMBL3590206	121970	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	501	7	2	4	4.0	CCOC(=O)C1CCCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)C1	10.1016/j.bmc.2015.03.062
	67496055	135435	None	0	Human	Functional	pEC50	=	8.2	8.2	239	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	7	2	4	3.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cccn1)C21CC1	nan
	CHEMBL3727798	135435	None	0	Human	Functional	pEC50	=	8.2	8.2	239	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	7	2	4	3.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cccn1)C21CC1	nan
	87421975	136329	None	0	Human	Functional	pEC50	=	8.1	8.1	165	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	CHEMBL3733130	136329	None	0	Human	Functional	pEC50	=	8.1	8.1	165	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	466	5	3	5	3.0	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1	nan
	67496570	136370	None	0	Human	Functional	pEC50	=	8.1	8.1	660	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	2.6	NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729822	136370	None	0	Human	Functional	pEC50	=	8.1	8.1	660	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	2.6	NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733937	136370	None	0	Human	Functional	pEC50	=	8.1	8.1	660	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	3	3	2.6	NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495789	135436	None	0	Human	Functional	pEC50	=	8.1	8.1	204	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	3	4.0	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	CHEMBL3727801	135436	None	0	Human	Functional	pEC50	=	8.1	8.1	204	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	3	4.0	NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1	nan
	67495768	135687	None	0	Human	Functional	pEC50	=	8.1	8.1	204	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	9	1	3	4.4	CCN(CC)CCN(CC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729293	135687	None	0	Human	Functional	pEC50	=	8.1	8.1	204	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	9	1	3	4.4	CCN(CC)CCN(CC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	57336781	145721	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	420	6	2	9	2.8	Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C4(O)CC4)co3)n2)c1	nan
	CHEMBL3915698	145721	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	420	6	2	9	2.8	Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C4(O)CC4)co3)n2)c1	nan
	87421981	135366	None	0	Human	Functional	pEC50	=	8.1	8.1	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	8	2	4	3.5	O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727408	135366	None	0	Human	Functional	pEC50	=	8.1	8.1	125	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	442	8	2	4	3.5	O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	127036710	136153	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	7	3	4	1.5	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)nc2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3732086	136153	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	448	7	3	4	1.5	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)nc2)[C@@H]2CC[C@H]1C21CC1	nan
	87422198	136380	None	0	Human	Functional	pEC50	=	8.1	8.1	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	8	2	5	3.0	O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730451	136380	None	0	Human	Functional	pEC50	=	8.1	8.1	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	8	2	5	3.0	O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733947	136380	None	0	Human	Functional	pEC50	=	8.1	8.1	70	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	8	2	5	3.0	O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	162649751	180195	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4748148	180195	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1	10.1016/j.ejmech.2021.113194
	67495050	135772	None	0	Human	Functional	pEC50	=	7.2	7.2	26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	4	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccnn1-c1ccccc1)C21CC1	nan
	CHEMBL3729807	135772	None	0	Human	Functional	pEC50	=	7.2	7.2	26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	4	5.0	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccnn1-c1ccccc1)C21CC1	nan
	CHEMBL5085818	217480	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O	10.1016/j.ejmech.2021.113805
	67495005	135527	None	0	Human	Functional	pEC50	=	7.2	7.2	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	8	2	3	3.5	CC1CCC(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)CC1	nan
	CHEMBL3728342	135527	None	0	Human	Functional	pEC50	=	7.2	7.2	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	8	2	3	3.5	CC1CCC(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)CC1	nan
	67495777	135552	None	0	Human	Functional	pEC50	=	7.2	7.2	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	7	3	3	2.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3728499	135552	None	0	Human	Functional	pEC50	=	7.2	7.2	9	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	7	3	3	2.2	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1	nan
	67495450	136280	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	6	2	4	4.6	Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c(C)s1	nan
	CHEMBL3732813	136280	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	499	6	2	4	4.6	Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c(C)s1	nan
	162671881	182950	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	432	5	3	4	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4791407	182950	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	432	5	3	4	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1	10.1016/j.ejmech.2021.113194
	67495882	135726	None	0	Human	Functional	pEC50	=	7.1	7.1	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	6	2	2	4.1	CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729543	135726	None	0	Human	Functional	pEC50	=	7.1	7.1	251	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	416	6	2	2	4.1	CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495372	136146	None	0	Human	Functional	pEC50	=	7.1	7.1	77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	2	3	3.4	COCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732041	136146	None	0	Human	Functional	pEC50	=	7.1	7.1	77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	2	3	3.4	COCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	71698529	90705	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	469	7	1	5	4.4	COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391256	90705	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	469	7	1	5	4.4	COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	168278240	191210	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187767	191210	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	67495757	136378	None	0	Human	Functional	pEC50	=	5.1	5.1	-37	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	11	2	4	3.9	CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728716	136378	None	0	Human	Functional	pEC50	=	5.1	5.1	-37	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	11	2	4	3.9	CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3733945	136378	None	0	Human	Functional	pEC50	=	5.1	5.1	-37	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	11	2	4	3.9	CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67495677	135538	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	9	2	5	3.3	O=C(NCc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728393	135538	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	506	9	2	5	3.3	O=C(NCc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495654	136209	None	0	Human	Functional	pEC50	=	7.1	7.1	109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	8	2	2	4.9	CCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732418	136209	None	0	Human	Functional	pEC50	=	7.1	7.1	109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	444	8	2	2	4.9	CCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	53552475	181394	None	3	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	348	4	3	3	2.6	O=C(CNC(=O)Nc1ccc(Br)cc1)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4762222	181394	None	3	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	348	4	3	3	2.6	O=C(CNC(=O)Nc1ccc(Br)cc1)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	145963525	162417	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4164673	162417	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	459	9	3	5	3.6	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	145956276	162771	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL4170201	162771	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method	ChEMBL	520	9	3	4	4.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL5087710	217604	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2021.113805
	122181320	121928	None	0	Human	Functional	pEC50	=	6.1	6.1	5	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590071	121928	None	0	Human	Functional	pEC50	=	6.1	6.1	5	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	525	9	4	4	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	122181409	121976	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	386	6	3	6	3.5	COC(=O)Nc1cccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)c1	10.1016/j.bmc.2015.03.062
	CHEMBL3590212	121976	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	386	6	3	6	3.5	COC(=O)Nc1cccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)c1	10.1016/j.bmc.2015.03.062
	67495713	136198	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	435	10	2	3	3.2	O=C(NCCc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732365	136198	None	0	Human	Functional	pEC50	=	6.1	6.1	-4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	435	10	2	3	3.2	O=C(NCCc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495219	136092	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	508	8	2	3	4.6	COC[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3731705	136092	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	508	8	2	3	4.6	COC[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL5076914	216957	None	4	Human	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O	10.1016/j.ejmech.2021.113805
	CHEMBL5078594	217056	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL		None	None	None		Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O	10.1016/j.ejmech.2021.113805
	24776341	3239	None	34	Human	Functional	pEC50	=	6.1	6.1	-43	4	GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.6019/CHEMBL5442687
	5831	3239	None	34	Human	Functional	pEC50	=	6.1	6.1	-43	4	GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.6019/CHEMBL5442687
	CHEMBL379761	3239	None	34	Human	Functional	pEC50	=	6.1	6.1	-43	4	GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2GPCR PRESTO-Tango dose-response in agonist mode with target: FPR2	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.6019/CHEMBL5442687
	67495741	135745	None	0	Human	Functional	pEC50	=	5.1	5.1	-8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	8	3	3	3.9	O=C(Nc1ccc2[nH]ccc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729642	135745	None	0	Human	Functional	pEC50	=	5.1	5.1	-8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	446	8	3	3	3.9	O=C(Nc1ccc2[nH]ccc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496174	135839	None	0	Human	Functional	pEC50	=	5.1	5.1	-33	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(F)c(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730234	135839	None	0	Human	Functional	pEC50	=	5.1	5.1	-33	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	517	9	2	3	4.0	O=C(NCc1ccc(F)c(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495408	135390	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	415	11	2	4	2.3	CC(=O)CCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727528	135390	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	415	11	2	4	2.3	CC(=O)CCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495972	136055	None	0	Human	Functional	pEC50	=	5.1	5.1	-15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	3.5	O=C(NCc1cc(F)cc(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731494	136055	None	0	Human	Functional	pEC50	=	5.1	5.1	-15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	9	2	3	3.5	O=C(NCc1cc(F)cc(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3407845	214094	None	0	Human	Functional	pEC50	=	5.1	5.1	1	2	Induction of calcium release in human FPR2 receptor-expressed HEK cell by cytosolic-free calcium assayInduction of calcium release in human FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay	ChEMBL		None	None	None		None	10.1021/jm501018q
	67495853	135364	None	0	Human	Functional	pEC50	=	7.1	7.1	34	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	2.4	NCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3727378	135364	None	0	Human	Functional	pEC50	=	7.1	7.1	34	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	431	7	3	3	2.4	NCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	145951632	162969	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	497	9	4	4	4.7	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	CHEMBL4173297	162969	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization	ChEMBL	497	9	4	4	4.7	O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1	10.1016/j.ejmech.2017.09.023
	87422282	136005	None	0	Human	Functional	pEC50	=	5.1	5.1	-33	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	8	2	5	4.2	O=C(Nc1nc2ccc(F)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3731186	136005	None	0	Human	Functional	pEC50	=	5.1	5.1	-33	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	8	2	5	4.2	O=C(Nc1nc2ccc(F)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495903	136396	None	0	Human	Functional	pEC50	=	5.1	5.1	-263	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	10	2	5	2.9	O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729493	136396	None	0	Human	Functional	pEC50	=	5.1	5.1	-263	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	10	2	5	2.9	O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733980	136396	None	0	Human	Functional	pEC50	=	5.1	5.1	-263	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	10	2	5	2.9	O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495914	135480	None	0	Human	Functional	pEC50	=	7.1	7.1	31	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.1	CCn1nc(C)cc1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728092	135480	None	0	Human	Functional	pEC50	=	7.1	7.1	31	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	7	2	4	4.1	CCn1nc(C)cc1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67494992	135907	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	6	3	3	3.9	Cc1nc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)Nc2ccc(Br)cc2)C32CC2)[nH]c1C	nan
	CHEMBL3730664	135907	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	482	6	3	3	3.9	Cc1nc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)Nc2ccc(Br)cc2)C32CC2)[nH]c1C	nan
	1292869	139204	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	350	4	2	4	3.7	CCc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	CHEMBL378679	139204	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	350	4	2	4	3.7	CCc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2006.04.068
	71698527	90703	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	6	1	5	3.2	COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391254	90703	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	3	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	427	6	1	5	3.2	COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2013.03.066
	67495765	135447	None	0	Human	Functional	pEC50	=	5.1	5.1	-8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	9	2	6	1.8	Cc1nonc1CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727847	135447	None	0	Human	Functional	pEC50	=	5.1	5.1	-8	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	9	2	6	1.8	Cc1nonc1CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	71699142	90740	None	0	Human	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	442	6	2	6	3.7	COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	CHEMBL2391449	90740	None	0	Human	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization	ChEMBL	442	6	2	6	3.7	COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2013.03.066
	87422142	135715	None	0	Human	Functional	pEC50	=	5.1	5.1	-18	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	9	2	6	3.1	CC(=O)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3729495	135715	None	0	Human	Functional	pEC50	=	5.1	5.1	-18	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	456	9	2	6	3.1	CC(=O)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	67495073	136297	None	0	Human	Functional	pEC50	=	7.1	7.1	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	401	11	2	3	3.1	CCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732930	136297	None	0	Human	Functional	pEC50	=	7.1	7.1	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	401	11	2	3	3.1	CCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496040	136154	None	0	Human	Functional	pEC50	=	5.1	5.1	-27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cccc(C(F)(F)F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732087	136154	None	0	Human	Functional	pEC50	=	5.1	5.1	-27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cccc(C(F)(F)F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495981	135732	None	0	Human	Functional	pEC50	=	5.1	5.1	-44	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1cc(C)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	CHEMBL3729585	135732	None	0	Human	Functional	pEC50	=	5.1	5.1	-44	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	9	2	3	3.7	Cc1cc(C)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	CHEMBL5093348	217914	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(c3ncccn3)CC2)C1=O	10.1016/j.ejmech.2021.113805
	57377977	154132	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	394	6	2	9	2.4	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccccc3)n2)n1	nan
	CHEMBL3984386	154132	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	394	6	2	9	2.4	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccccc3)n2)n1	nan
	87422343	135941	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	6	3	5	1.7	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730856	135941	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	6	3	5	1.7	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495034	135968	None	0	Human	Functional	pEC50	=	8.1	8.1	181	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	4.1	CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730991	135968	None	0	Human	Functional	pEC50	=	8.1	8.1	181	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	4.1	CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67496009	135417	None	0	Human	Functional	pEC50	=	8.1	8.1	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	484	6	3	3	4.1	Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)[nH]c1C	nan
	CHEMBL3727697	135417	None	0	Human	Functional	pEC50	=	8.1	8.1	6	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	484	6	3	3	4.1	Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)[nH]c1C	nan
	87422284	135666	None	0	Human	Functional	pEC50	=	8.1	8.1	57	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	5	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1	nan
	CHEMBL3729189	135666	None	0	Human	Functional	pEC50	=	8.1	8.1	57	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	5	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1	nan
	87422074	136022	None	0	Human	Functional	pEC50	=	8.1	8.1	114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	4	3	5	2.4	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1	nan
	CHEMBL3731273	136022	None	0	Human	Functional	pEC50	=	8.1	8.1	114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	438	4	3	5	2.4	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1	nan
	44413497	78148	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	435	4	2	5	5.1	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL210303	78148	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	435	4	2	5	5.1	CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C	10.1016/j.bmcl.2006.04.068
	67496490	135632	None	0	Human	Functional	pEC50	=	7.1	7.1	85	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	7	2	3	3.2	CN(C)C(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728947	135632	None	0	Human	Functional	pEC50	=	7.1	7.1	85	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	7	2	3	3.2	CN(C)C(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422056	135880	None	0	Human	Functional	pEC50	=	7.1	7.1	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	441	7	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCO)C21CC1	nan
	CHEMBL3730490	135880	None	0	Human	Functional	pEC50	=	7.1	7.1	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	441	7	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCO)C21CC1	nan
	67496609	136139	None	0	Human	Functional	pEC50	=	7.1	7.1	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	549	7	2	4	4.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(c1ccccc1)N1CCOCC1)C21CC1	nan
	CHEMBL3732008	136139	None	0	Human	Functional	pEC50	=	7.1	7.1	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	549	7	2	4	4.4	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(c1ccccc1)N1CCOCC1)C21CC1	nan
	67495637	136208	None	0	Human	Functional	pEC50	=	7.1	7.1	69	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	4.1	CCN(CC)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3732416	136208	None	0	Human	Functional	pEC50	=	7.1	7.1	69	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	9	2	3	4.1	CCN(CC)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	162660629	181373	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4761978	181373	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	4776370	121977	None	7	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	373	7	2	5	4.4	CCOc1ccc2[nH]c(SCC(=O)Nc3ccccc3SC)nc2c1	10.1016/j.bmc.2015.03.062
	CHEMBL3590213	121977	None	7	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	373	7	2	5	4.4	CCOc1ccc2[nH]c(SCC(=O)Nc3ccccc3SC)nc2c1	10.1016/j.bmc.2015.03.062
	67495656	136149	None	0	Human	Functional	pEC50	=	5.1	5.1	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	415	11	2	3	3.4	CCC(CC)CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732051	136149	None	0	Human	Functional	pEC50	=	5.1	5.1	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	415	11	2	3	3.4	CCC(CC)CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44413548	79823	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	382	4	2	4	4.4	Cc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	CHEMBL211957	79823	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	382	4	2	4	4.4	Cc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	24776355	94219	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	436	3	1	3	4.9	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	CHEMBL249537	94219	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	436	3	1	3	4.9	CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)C1	10.1016/j.bmcl.2007.09.043
	67495598	136311	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	531	6	2	4	5.5	Cc1onc(-c2ccccc2)c1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3733039	136311	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	531	6	2	4	5.5	Cc1onc(-c2ccccc2)c1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495242	135836	None	0	Human	Functional	pEC50	=	7.1	7.1	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	4	2	2	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CC1)C21CC1	nan
	CHEMBL3730215	135836	None	0	Human	Functional	pEC50	=	7.1	7.1	36	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	402	4	2	2	3.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CC1)C21CC1	nan
	67495596	135844	None	0	Human	Functional	pEC50	=	7.1	7.1	43	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	8	3	6	0.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN2CCNC2=O)C32CC2)n1	nan
	CHEMBL3730255	135844	None	0	Human	Functional	pEC50	=	7.1	7.1	43	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	457	8	3	6	0.9	CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN2CCNC2=O)C32CC2)n1	nan
	87422303	136141	None	0	Human	Functional	pEC50	=	7.1	7.1	102	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	5	2	4	3.7	CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	CHEMBL3732014	136141	None	0	Human	Functional	pEC50	=	7.1	7.1	102	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	425	5	2	4	3.7	CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1	nan
	67495351	136381	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	8	2	3	4.5	O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729485	136381	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	8	2	3	4.5	O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733948	136381	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	475	8	2	3	4.5	O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	57378195	153272	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	428	6	2	9	3.1	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncsc3-c3cccc(F)c3)n2)n1	nan
	CHEMBL3977012	153272	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.	ChEMBL	428	6	2	9	3.1	CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncsc3-c3cccc(F)c3)n2)n1	nan
	44236329	197903	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL552396	197903	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	44236329	197903	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL552396	197903	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	381	6	1	5	2.9	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1	10.1021/jm900592h
	67495302	136346	None	0	Human	Functional	pEC50	=	5.1	5.1	-316	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	3	3.8	O=C(NCCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733261	136346	None	0	Human	Functional	pEC50	=	5.1	5.1	-316	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	469	10	2	3	3.8	O=C(NCCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	44413563	79759	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	396	3	2	4	4.6	Cc1ccc(NC(=O)Nc2c(C(C)(C)C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	CHEMBL211595	79759	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	396	3	2	4	4.6	Cc1ccc(NC(=O)Nc2c(C(C)(C)C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	24776347	154850	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	430	5	1	4	5.2	COc1ccc2[nH]c(C(=O)N3CCC(n4c(CC(C)C)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	CHEMBL400089	154850	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay	ChEMBL	430	5	1	4	5.2	COc1ccc2[nH]c(C(=O)N3CCC(n4c(CC(C)C)nc5ccccc54)CC3)cc2c1	10.1016/j.bmcl.2007.09.043
	67495602	135950	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	11	2	5	2.2	O=C(NCCCn1ccnc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730904	135950	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	439	11	2	5	2.2	O=C(NCCCn1ccnc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496142	135392	None	0	Human	Functional	pEC50	=	5.1	5.1	-23	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	10	2	4	3.3	CC(=O)c1cccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	CHEMBL3727532	135392	None	0	Human	Functional	pEC50	=	5.1	5.1	-23	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	10	2	4	3.3	CC(=O)c1cccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1	nan
	146648729	192221	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	438	5	2	6	3.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3F)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5203364	192221	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay	ChEMBL	438	5	2	6	3.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3F)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	87421997	136163	None	0	Human	Functional	pEC50	=	5.1	5.1	-77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	524	9	2	5	5.2	O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732146	136163	None	0	Human	Functional	pEC50	=	5.1	5.1	-77	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	524	9	2	5	5.2	O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	87422124	136114	None	0	Human	Functional	pEC50	=	6.1	6.1	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.6	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CO)CC1)C21CC1	nan
	CHEMBL3731851	136114	None	0	Human	Functional	pEC50	=	6.1	6.1	21	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	5	3	5	3.6	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CO)CC1)C21CC1	nan
	122181231	121772	None	0	Human	Functional	pEC50	=	7.1	7.1	2	3	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilizationAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	CHEMBL3588871	121772	None	0	Human	Functional	pEC50	=	7.1	7.1	2	3	Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilizationAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.ejmech.2017.09.023
	122181324	121931	None	0	Human	Functional	pEC50	=	6.1	6.1	2	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590075	121931	None	0	Human	Functional	pEC50	=	6.1	6.1	2	2	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	542	9	4	3	6.1	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	67495936	136390	None	0	Human	Functional	pEC50	=	5.1	5.1	-114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.2	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3730257	136390	None	0	Human	Functional	pEC50	=	5.1	5.1	-114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.2	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3733975	136390	None	0	Human	Functional	pEC50	=	5.1	5.1	-114	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	465	11	2	4	3.2	COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67495884	136118	None	0	Human	Functional	pEC50	=	7.1	7.1	30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	5	2	2	4.9	CC1(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1(Cl)Cl	nan
	CHEMBL3731870	136118	None	0	Human	Functional	pEC50	=	7.1	7.1	30	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	496	5	2	2	4.9	CC1(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1(Cl)Cl	nan
	67496028	135755	None	0	Human	Functional	pEC50	=	5.1	5.1	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	11	2	4	3.7	O=C(NCc1cccc(OC(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3729706	135755	None	0	Human	Functional	pEC50	=	5.1	5.1	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	11	2	4	3.7	O=C(NCc1cccc(OC(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495883	135677	None	0	Human	Functional	pEC50	=	7.1	7.1	53	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	474	8	2	4	3.7	COC(=O)CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729231	135677	None	0	Human	Functional	pEC50	=	7.1	7.1	53	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	474	8	2	4	3.7	COC(=O)CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181232	121913	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589946	121913	None	0	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	44233648	197314	None	0	Human	Functional	pEC50	=	5.1	5.1	2	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL549570	197314	None	0	Human	Functional	pEC50	=	5.1	5.1	2	2	Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	431	6	1	5	3.8	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1	10.1021/jm900592h
	67495784	136391	None	0	Human	Functional	pEC50	=	5.1	5.1	-1348	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	10	2	3	3.9	O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733191	136391	None	0	Human	Functional	pEC50	=	5.1	5.1	-1348	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	10	2	3	3.9	O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3733976	136391	None	0	Human	Functional	pEC50	=	5.1	5.1	-1348	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	10	2	3	3.9	O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL5084099	217385	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay	ChEMBL		None	None	None		CC(C)n1cc(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)cn1	10.1016/j.ejmech.2021.113805
	67495285	135483	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	7	3	5	1.3	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2cnc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728104	135483	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	7	3	5	1.3	NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2cnc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495336	135656	None	0	Human	Functional	pEC50	=	5.1	5.1	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	10	2	5	2.5	COc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)ccn1	nan
	CHEMBL3729111	135656	None	0	Human	Functional	pEC50	=	5.1	5.1	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	10	2	5	2.5	COc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)ccn1	nan
	162663817	182034	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	419	4	3	4	3.6	Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4779714	182034	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	419	4	3	4	3.6	Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1	10.1016/j.ejmech.2021.113194
	67495672	136288	None	0	Human	Functional	pEC50	=	6.1	6.1	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	9	2	3	4.4	CC(NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1)c1ccc(Br)cc1	nan
	CHEMBL3732885	136288	None	0	Human	Functional	pEC50	=	6.1	6.1	-11	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	513	9	2	3	4.4	CC(NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1)c1ccc(Br)cc1	nan
	67494972	135771	None	0	Human	Functional	pEC50	=	6.1	6.1	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	9	2	3	3.4	CCOCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729806	135771	None	0	Human	Functional	pEC50	=	6.1	6.1	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	9	2	3	3.4	CCOCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67494874	135521	None	0	Human	Functional	pEC50	=	8.1	8.1	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	9	2	4	3.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3728297	135521	None	0	Human	Functional	pEC50	=	8.1	8.1	51	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	437	9	2	4	3.5	COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	67495717	136182	None	0	Human	Functional	pEC50	=	8.1	8.1	95	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	7	2	4	3.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1	nan
	CHEMBL3732253	136182	None	0	Human	Functional	pEC50	=	8.1	8.1	95	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	7	2	4	3.6	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1	nan
	87422368	135921	None	0	Human	Functional	pEC50	=	8.0	8.0	954	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	5	1.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	CHEMBL3730714	135921	None	0	Human	Functional	pEC50	=	8.0	8.0	954	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	479	6	3	5	1.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1	nan
	87422145	136264	None	0	Human	Functional	pEC50	=	8.0	8.0	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	4	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1	nan
	CHEMBL3732729	136264	None	0	Human	Functional	pEC50	=	8.0	8.0	38	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	452	4	3	5	2.8	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1	nan
	67495459	136204	None	0	Human	Functional	pEC50	=	8.0	8.0	31	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732403	136204	None	0	Human	Functional	pEC50	=	8.0	8.0	31	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	521	8	2	3	4.5	O=C(Nc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495311	135695	None	0	Human	Functional	pEC50	=	8.0	8.0	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	7	2	4	3.0	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	CHEMBL3729352	135695	None	0	Human	Functional	pEC50	=	8.0	8.0	97	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	500	7	2	4	3.0	CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1	nan
	67496035	136076	None	0	Human	Functional	pEC50	=	8.0	8.0	891	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	5	2	4	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1COCCO1)C21CC1	nan
	CHEMBL3731632	136076	None	0	Human	Functional	pEC50	=	8.0	8.0	891	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	460	5	2	4	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1COCCO1)C21CC1	nan
	67495282	135644	None	0	Human	Functional	pEC50	=	8.0	8.0	660	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	2	3	3.3	CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729034	135644	None	0	Human	Functional	pEC50	=	8.0	8.0	660	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	445	7	2	3	3.3	CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	67495568	136041	None	0	Human	Functional	pEC50	=	8.0	8.0	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCO)C21CC1	nan
	CHEMBL3731406	136041	None	0	Human	Functional	pEC50	=	8.0	8.0	812	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	432	7	3	3	3.1	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCO)C21CC1	nan
	1240119	138799	None	7	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	400	3	2	4	3.9	Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	CHEMBL377969	138799	None	7	Human	Functional	pEC50	=	7.1	7.1	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	400	3	2	4	3.9	Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C	10.1016/j.bmcl.2006.04.068
	727813	19139	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	288	5	2	2	3.2	COc1ccc(CCNC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL1289379	19139	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay	ChEMBL	288	5	2	2	3.2	COc1ccc(CCNC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.bmc.2015.03.062
	44236330	194956	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	194956	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	44236330	194956	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL539401	194956	None	0	Human	Functional	pEC50	=	6.1	6.1	1	2	Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay	ChEMBL	377	6	1	5	3.1	COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1	10.1021/jm900592h
	CHEMBL3407845	214094	None	0	Mouse	Functional	pEC50	=	5.1	5.1	-1	2	Induction of calcium release in mouse FPR2 receptor-expressed HEK cell by cytosolic-free calcium assayInduction of calcium release in mouse FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay	ChEMBL		None	None	None		None	10.1021/jm501018q
	67495189	136388	None	0	Human	Functional	pEC50	=	5.0	5.0	-20	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC	nan
	CHEMBL3733201	136388	None	0	Human	Functional	pEC50	=	5.0	5.0	-20	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC	nan
	CHEMBL3733973	136388	None	0	Human	Functional	pEC50	=	5.0	5.0	-20	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	481	11	2	5	3.1	COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC	nan
	67496363	135610	None	0	Human	Functional	pEC50	=	5.0	5.0	-29	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728809	135610	None	0	Human	Functional	pEC50	=	5.0	5.0	-29	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496175	136371	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1	nan
	CHEMBL3728165	136371	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1	nan
	CHEMBL3733938	136371	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	487	10	2	4	3.4	COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1	nan
	67495803	135496	None	0	Human	Functional	pEC50	=	5.0	5.0	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	8	2	6	3.0	O=C(Nc1cccc2nonc12)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728174	135496	None	0	Human	Functional	pEC50	=	5.0	5.0	-12	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	449	8	2	6	3.0	O=C(Nc1cccc2nonc12)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496010	135529	None	0	Human	Functional	pEC50	=	7.0	7.0	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	CHEMBL3728344	135529	None	0	Human	Functional	pEC50	=	7.0	7.0	5	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	454	10	2	6	2.3	CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1	nan
	122181232	121913	None	0	Human	Functional	pEC50	=	6.0	6.0	8	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3589946	121913	None	0	Human	Functional	pEC50	=	6.0	6.0	8	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	67496034	135931	None	0	Human	Functional	pEC50	=	7.0	7.0	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	11	2	5	3.3	CC(C)Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	CHEMBL3730804	135931	None	0	Human	Functional	pEC50	=	7.0	7.0	15	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	468	11	2	5	3.3	CC(C)Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1	nan
	67495569	135859	None	0	Human	Functional	pEC50	=	7.0	7.0	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	429	12	2	4	2.7	CC(=O)CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730358	135859	None	0	Human	Functional	pEC50	=	7.0	7.0	28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	429	12	2	4	2.7	CC(=O)CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495825	136211	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	422	8	2	4	3.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)nc1	nan
	CHEMBL3732432	136211	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	422	8	2	4	3.1	Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)nc1	nan
	24776341	3239	None	34	Human	Functional	pEC50	=	7.0	7.0	-43	4	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	5831	3239	None	34	Human	Functional	pEC50	=	7.0	7.0	-43	4	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	CHEMBL379761	3239	None	34	Human	Functional	pEC50	=	7.0	7.0	-43	4	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	122181231	121772	None	0	Human	Functional	pEC50	=	7.0	7.0	2	3	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3588871	121772	None	0	Human	Functional	pEC50	=	7.0	7.0	2	3	Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay	ChEMBL	555	10	4	5	5.3	COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	89685010	135569	None	0	Human	Functional	pEC50	=	7.0	7.0	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	5	2	4	4.7	CC(C)(C)OC(=O)N1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3728558	135569	None	0	Human	Functional	pEC50	=	7.0	7.0	13	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	543	5	2	4	4.7	CC(C)(C)OC(=O)N1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422207	135807	None	0	Human	Functional	pEC50	=	7.0	7.0	104	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	6	3	5	2.4	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	CHEMBL3730036	135807	None	0	Human	Functional	pEC50	=	7.0	7.0	104	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	427	6	3	5	2.4	O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1	nan
	67495863	135964	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	4	4.3	Cc1nn(C)c(Cl)c1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730978	135964	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	502	5	2	4	4.3	Cc1nn(C)c(Cl)c1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1	nan
	87422055	135670	None	0	Human	Functional	pEC50	=	5.0	5.0	-63	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	8	2	5	4.2	CC(C)(C)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	CHEMBL3729199	135670	None	0	Human	Functional	pEC50	=	5.0	5.0	-63	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	8	2	5	4.2	CC(C)(C)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1	nan
	162655466	180900	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	388	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1	10.1016/j.ejmech.2021.113194
	CHEMBL4756434	180900	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay	ChEMBL	388	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1	10.1016/j.ejmech.2021.113194
	67495729	135774	None	0	Human	Functional	pEC50	=	7.0	7.0	81	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	6	2	4	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCOCC1)C21CC1	nan
	CHEMBL3729813	135774	None	0	Human	Functional	pEC50	=	7.0	7.0	81	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	473	6	2	4	2.7	O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCOCC1)C21CC1	nan
	67495852	135906	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	12	2	6	3.0	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3730658	135906	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	472	12	2	6	3.0	CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1	nan
	122181319	121927	None	0	Human	Functional	pEC50	=	6.0	6.0	7	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	CHEMBL3590070	121927	None	0	Human	Functional	pEC50	=	6.0	6.0	7	2	Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid	ChEMBL	524	9	4	3	5.9	COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1	10.1016/j.bmc.2014.12.007
	67495601	135526	None	0	Human	Functional	pEC50	=	5.0	5.0	-2570	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	10	2	3	4.5	O=C(NCCc1ccc(Cl)cc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3728341	135526	None	0	Human	Functional	pEC50	=	5.0	5.0	-2570	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	503	10	2	3	4.5	O=C(NCCc1ccc(Cl)cc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495987	136307	None	0	Human	Functional	pEC50	=	5.0	5.0	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	10	2	4	3.3	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	CHEMBL3732990	136307	None	0	Human	Functional	pEC50	=	5.0	5.0	-16	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	463	10	2	4	3.3	CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1	nan
	87422135	135797	None	0	Human	Functional	pEC50	=	7.0	7.0	27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	424	6	3	5	2.0	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	CHEMBL3729979	135797	None	0	Human	Functional	pEC50	=	7.0	7.0	27	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	424	6	3	5	2.0	CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1	nan
	22430395	79856	None	4	Human	Functional	pEC50	=	6.0	6.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	354	3	2	4	3.6	Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	CHEMBL212109	79856	None	4	Human	Functional	pEC50	=	6.0	6.0	-	1	Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells	ChEMBL	354	3	2	4	3.6	Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1F	10.1016/j.bmcl.2006.04.068
	168278228	191189	None	0	Human	Functional	pEC50	=	6.0	6.0	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187530	191189	None	0	Human	Functional	pEC50	=	6.0	6.0	3	2	Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	67495811	136185	None	0	Human	Functional	pEC50	=	5	5.0	-109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	6	4.0	O=C(Nc1nc(-c2ccccc2)ns1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3732281	136185	None	0	Human	Functional	pEC50	=	5	5.0	-109	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	491	9	2	6	4.0	O=C(Nc1nc(-c2ccccc2)ns1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67495023	135379	None	0	Human	Functional	pEC50	=	6	6.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	CHEMBL3727461	135379	None	0	Human	Functional	pEC50	=	6	6.0	1	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	470	10	2	6	2.8	CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1	nan
	67496494	135455	None	0	Human	Functional	pEC50	=	5	5.0	-28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cc(C(F)(F)F)ccc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3727911	135455	None	0	Human	Functional	pEC50	=	5	5.0	-28	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	507	9	2	3	4.3	O=C(NCc1cc(C(F)(F)F)ccc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	67496552	135889	None	0	Human	Functional	pEC50	=	5	5.0	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	523	9	2	3	4.8	O=C(NCc1cc(C(F)(F)F)ccc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	CHEMBL3730523	135889	None	0	Human	Functional	pEC50	=	5	5.0	-26	2	Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay	ChEMBL	523	9	2	3	4.8	O=C(NCc1cc(C(F)(F)F)ccc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1	nan
	164916036	191696	None	0	Human	Functional	pIC50	=	8	8.0	147	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5195186	191696	None	0	Human	Functional	pIC50	=	8	8.0	147	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	168281597	191379	None	0	Human	Functional	pIC50	=	7.9	7.9	50	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5190571	191379	None	0	Human	Functional	pIC50	=	7.9	7.9	50	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	168291793	192040	None	0	Human	Functional	pIC50	=	5.9	5.9	2	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5200365	192040	None	0	Human	Functional	pIC50	=	5.9	5.9	2	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	168278228	191189	None	0	Human	Functional	pIC50	=	4.9	4.9	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187530	191189	None	0	Human	Functional	pIC50	=	4.9	4.9	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	155517009	170258	None	0	Human	Functional	pIC50	=	4.9	4.9	-3	2	Antagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	CHEMBL4444320	170258	None	0	Human	Functional	pIC50	=	4.9	4.9	-3	2	Antagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometry	ChEMBL	469	9	3	4	3.4	COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1	10.1039/C9MD00336C
	168279295	191155	None	0	Human	Functional	pIC50	=	7.9	7.9	91	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187135	191155	None	0	Human	Functional	pIC50	=	7.9	7.9	91	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	168283038	191036	None	0	Human	Functional	pIC50	=	6.9	6.9	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185462	191036	None	0	Human	Functional	pIC50	=	6.9	6.9	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	429	5	2	4	3.4	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1	10.1021/acs.jmedchem.1c02203
	168272319	190684	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5180261	190684	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	168283383	190953	None	0	Human	Functional	pIC50	=	4.8	4.8	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184396	190953	None	0	Human	Functional	pIC50	=	4.8	4.8	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	122181411	121980	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	415	7	2	4	5.4	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590216	121980	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	415	7	2	4	5.4	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1	10.1016/j.bmc.2015.03.062
	146597621	191446	None	0	Human	Functional	pIC50	=	7.7	7.7	33	2	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5191583	191446	None	0	Human	Functional	pIC50	=	7.7	7.7	33	2	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	419	5	2	5	4.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1	10.1021/acsmedchemlett.2c00079
	163322252	191989	None	9	Human	Functional	pIC50	=	6.7	6.7	26	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5199629	191989	None	9	Human	Functional	pIC50	=	6.7	6.7	26	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	168281748	190994	None	0	Human	Functional	pIC50	=	6.6	6.6	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184913	190994	None	0	Human	Functional	pIC50	=	6.6	6.6	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168279956	191192	None	0	Human	Functional	pIC50	=	6.6	6.6	4	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187563	191192	None	0	Human	Functional	pIC50	=	6.6	6.6	4	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	460	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168274924	190378	None	0	Human	Functional	pIC50	=	5.6	5.6	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5175543	190378	None	0	Human	Functional	pIC50	=	5.6	5.6	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	456	5	2	3	4.8	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21	10.1021/acs.jmedchem.1c02203
	146597625	191371	None	2	Human	Functional	pIC50	=	7.6	7.6	47	2	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	CHEMBL5190385	191371	None	2	Human	Functional	pIC50	=	7.6	7.6	47	2	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	420	5	2	6	3.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1	10.1021/acsmedchemlett.2c00079
	168286767	191791	None	0	Human	Functional	pIC50	=	7.5	7.5	53	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5196551	191791	None	0	Human	Functional	pIC50	=	7.5	7.5	53	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168293205	192247	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	430	5	2	3	3.7	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5203658	192247	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	430	5	2	3	3.7	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1	10.1021/acs.jmedchem.1c02203
	168282160	190959	None	0	Human	Functional	pIC50	=	5.5	5.5	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5184490	190959	None	0	Human	Functional	pIC50	=	5.5	5.5	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1	10.1021/acs.jmedchem.1c02203
	164916034	191799	None	0	Human	Functional	pIC50	=	6.5	6.5	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5196771	191799	None	0	Human	Functional	pIC50	=	6.5	6.5	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	168269851	190075	None	0	Human	Functional	pIC50	=	5.5	5.5	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5170711	190075	None	0	Human	Functional	pIC50	=	5.5	5.5	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	442	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168273654	190435	None	0	Human	Functional	pIC50	=	5.4	5.4	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5176452	190435	None	0	Human	Functional	pIC50	=	5.4	5.4	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	437	6	4	4	2.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1	10.1021/acs.jmedchem.1c02203
	168292800	192171	None	0	Human	Functional	pIC50	=	5.4	5.4	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5202577	192171	None	0	Human	Functional	pIC50	=	5.4	5.4	3	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1	10.1021/acs.jmedchem.1c02203
	164916035	192459	None	3	Human	Functional	pIC50	=	8.4	8.4	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5207056	192459	None	3	Human	Functional	pIC50	=	8.4	8.4	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	168280238	191063	None	0	Human	Functional	pIC50	=	5.4	5.4	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185921	191063	None	0	Human	Functional	pIC50	=	5.4	5.4	6	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	428	5	2	3	4.0	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168283929	191209	None	0	Human	Functional	pIC50	=	5.4	5.4	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5187763	191209	None	0	Human	Functional	pIC50	=	5.4	5.4	1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1	10.1021/acs.jmedchem.1c02203
	168278342	191260	None	0	Human	Functional	pIC50	=	4.3	4.3	-1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5188537	191260	None	0	Human	Functional	pIC50	=	4.3	4.3	-1	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	394	5	2	3	3.4	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1	10.1021/acs.jmedchem.1c02203
	28	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	3292447	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	CHEMBL20963	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	168284664	191622	None	0	Human	Functional	pIC50	=	6.2	6.2	7	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	488	5	2	3	4.9	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21	10.1021/acs.jmedchem.1c02203
	CHEMBL5193947	191622	None	0	Human	Functional	pIC50	=	6.2	6.2	7	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	488	5	2	3	4.9	CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21	10.1021/acs.jmedchem.1c02203
	168283359	190921	None	0	Human	Functional	pIC50	=	5.2	5.2	5	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5183856	190921	None	0	Human	Functional	pIC50	=	5.2	5.2	5	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	380	5	2	3	3.1	N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1	10.1021/acs.jmedchem.1c02203
	122181410	121979	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	417	7	3	5	4.8	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(O)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590215	121979	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	417	7	3	5	4.8	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(O)cc2)cc1	10.1016/j.bmc.2015.03.062
	11024	688	None	24	Human	Functional	pIC50	=	8.1	8.1	-4	4	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	122583088	688	None	24	Human	Functional	pIC50	=	8.1	8.1	-4	4	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	CHEMBL4784510	688	None	24	Human	Functional	pIC50	=	8.1	8.1	-4	4	Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acsmedchemlett.2c00079
	6263	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay	ChEMBL	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	10.1016/j.bmc.2015.03.062
	91827351	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay	ChEMBL	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	10.1016/j.bmc.2015.03.062
	CHEMBL3590218	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay	ChEMBL	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	10.1016/j.bmc.2015.03.062
	168282231	191071	None	0	Human	Functional	pIC50	=	7.1	7.1	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	CHEMBL5185982	191071	None	0	Human	Functional	pIC50	=	7.1	7.1	16	2	Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay	ChEMBL	446	5	2	3	4.2	N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1	10.1021/acs.jmedchem.1c02203
	122181412	121981	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	431	8	2	5	5.1	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1	10.1016/j.bmc.2015.03.062
	CHEMBL3590217	121981	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay	ChEMBL	431	8	2	5	5.1	CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1	10.1016/j.bmc.2015.03.062
	49834265	273	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	FPR2/ALX internalization into monocytes.FPR2/ALX internalization into monocytes.	Guide to Pharmacology	428	6	1	8	4.0	Cc1cccc(c1)c1oc(nc1C(=O)Nc1cnn(n1)Cc1occ(n1)C(F)(F)C)C	27730665
	9511	273	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	FPR2/ALX internalization into monocytes.FPR2/ALX internalization into monocytes.	Guide to Pharmacology	428	6	1	8	4.0	Cc1cccc(c1)c1oc(nc1C(=O)Nc1cnn(n1)Cc1occ(n1)C(F)(F)C)C	27730665
	16126783	504	None	0	Human	Functional	pEC50	=	11.1	11.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O	22449948
	6239	504	None	0	Human	Functional	pEC50	=	11.1	11.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O	22449948
	CHEMBL519495	504	None	0	Human	Functional	pEC50	=	11.1	11.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O	22449948
	5555	3417	None	0	Human	Functional	pEC50	=	11.4	11.4	1	2	UnclassifiedUnclassified	Guide to Pharmacology	390	14	3	5	3.6	CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)OC)O)O)O	22449948
	71519431	3417	None	0	Human	Functional	pEC50	=	11.4	11.4	1	2	UnclassifiedUnclassified	Guide to Pharmacology	390	14	3	5	3.6	CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)OC)O)O)O	22449948
	16135249	3196	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23549262
	6244	3196	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23549262
	71312203	3196	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23549262
	1023	1673	None	0	Mouse	Functional	pEC50	=	5.3	5.3	-47863	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23160941
	5841	1668	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-141253	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18606697
	5841	1668	None	0	Mouse	Functional	pEC50	=	5.6	5.6	-141253	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23160941
	11751175	3257	None	0	Human	Functional	pEC50	=	5.7	5.7	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	445	8	2	5	4.8	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC	15308762
	6265	3257	None	0	Human	Functional	pEC50	=	5.7	5.7	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	445	8	2	5	4.8	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC	15308762
	1044	425	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10882119
	1044	425	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12368905
	1044	425	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12560218
	1044	425	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16278303
	134611881	2335	None	0	Human	Functional	pEC50	=	6	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11015447
	5527	2335	None	0	Human	Functional	pEC50	=	6	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11015447
	CHEMBL530345	2335	None	0	Human	Functional	pEC50	=	6	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11015447
	DB16532	2335	None	0	Human	Functional	pEC50	=	6	6.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11015447
	11751175	3257	None	0	Mouse	Functional	pEC50	=	6.2	6.2	3	2	UnclassifiedUnclassified	Guide to Pharmacology	445	8	2	5	4.8	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC	23160941
	6265	3257	None	0	Mouse	Functional	pEC50	=	6.2	6.2	3	2	UnclassifiedUnclassified	Guide to Pharmacology	445	8	2	5	4.8	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC	23160941
	5834	1160	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	UnclassifiedUnclassified	Guide to Pharmacology	517	7	1	5	5.1	COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1	22607879
	73755161	1160	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	UnclassifiedUnclassified	Guide to Pharmacology	517	7	1	5	5.1	COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1	22607879
	6268	310	None	3	Human	Functional	pEC50	=	6.3	6.3	2	3	UnclassifiedUnclassified	Guide to Pharmacology	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	19903830
	727787	310	None	3	Human	Functional	pEC50	=	6.3	6.3	2	3	UnclassifiedUnclassified	Guide to Pharmacology	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	19903830
	CHEMBL1289260	310	None	3	Human	Functional	pEC50	=	6.3	6.3	2	3	UnclassifiedUnclassified	Guide to Pharmacology	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	19903830
	3935	1618	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-50	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17237393
	1047	1952	None	20	Mouse	Functional	pEC50	=	6.5	6.5	-281	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15153530
	16131438	1952	None	20	Mouse	Functional	pEC50	=	6.5	6.5	-281	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15153530
	56947109	1952	None	20	Mouse	Functional	pEC50	=	6.5	6.5	-281	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15153530
	CHEMBL4447799	1952	None	20	Mouse	Functional	pEC50	=	6.5	6.5	-281	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15153530
	6242	3591	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9892621
	5841	1668	None	0	Human	Functional	pEC50	=	6.7	6.7	-9999	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16025565
	155817495	1205	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15879124
	6266	1205	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15879124
	24776341	3239	None	34	Mouse	Functional	pEC50	=	6.9	6.9	-60	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	23160941
	5831	3239	None	34	Mouse	Functional	pEC50	=	6.9	6.9	-60	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	23160941
	CHEMBL379761	3239	None	34	Mouse	Functional	pEC50	=	6.9	6.9	-60	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	23160941
	4865	407	None	0	Human	Functional	pEC50	=	7	7.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11160457
	4865	407	None	0	Human	Functional	pEC50	=	7	7.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11316806
	6249	3945	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11818541
	6245	3725	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10229829
	24776341	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	16697190
	5831	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	16697190
	CHEMBL379761	3239	None	34	Human	Functional	pEC50	=	7.4	7.4	-43	4	UnclassifiedUnclassified	Guide to Pharmacology	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	16697190
	155817496	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14662730
	155817496	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17513790
	16207728	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14662730
	16207728	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17513790
	6275	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14662730
	6275	3599	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17513790
	1023	1673	None	0	Human	Functional	pEC50	=	7.8	7.8	-151	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16025565
	11024	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	122583088	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	CHEMBL4784510	688	None	24	Human	Functional	pEC50	=	8.3	8.3	-4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	1047	1952	None	20	Human	Functional	pEC50	=	8.5	8.5	-3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15465011
	16131438	1952	None	20	Human	Functional	pEC50	=	8.5	8.5	-3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15465011
	56947109	1952	None	20	Human	Functional	pEC50	=	8.5	8.5	-3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15465011
	CHEMBL4447799	1952	None	20	Human	Functional	pEC50	=	8.5	8.5	-3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15465011
	6267	3221	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20542250
	25074458	2583	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11435499
	25074458	2583	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9853614
	6240	2583	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11435499
	6240	2583	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9853614
	6251	3561	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14662730
	11024	688	None	24	Mouse	Functional	pEC50	=	9.3	9.3	4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	122583088	688	None	24	Mouse	Functional	pEC50	=	9.3	9.3	4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	CHEMBL4784510	688	None	24	Mouse	Functional	pEC50	=	9.3	9.3	4	4	UnclassifiedUnclassified	Guide to Pharmacology	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	32407089
	1048	4085	None	0	Mouse	Functional	pEC50	=	9.6	9.6	3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11035102
	1048	4085	None	0	Mouse	Functional	pEC50	=	9.6	9.6	3	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23160941
	1041	2092	None	0	Human	Functional	pEC50	None	5.2	5.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8573582
	1039	3258	None	0	Human	Functional	pEC50	None	5.2	5.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	431	7	3	5	4.5	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)O	17652444
	11647668	3258	None	0	Human	Functional	pEC50	None	5.2	5.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	431	7	3	5	4.5	CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)O	17652444
	3934	3318	None	0	Human	Functional	pEC50	~	11.9	11.9	6	2	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O	20080636
	4356	3318	None	0	Human	Functional	pEC50	~	11.9	11.9	6	2	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O	20080636
	73755062	3318	None	0	Human	Functional	pEC50	~	11.9	11.9	6	2	UnclassifiedUnclassified	Guide to Pharmacology	376	14	4	4	3.5	CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O	20080636
	1034	2392	None	22	Human	Functional	pEC50	~	12	12.0	-10	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	20080636
	5280914	2392	None	22	Human	Functional	pEC50	~	12	12.0	-10	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	20080636
	CHEMBL392438	2392	None	22	Human	Functional	pEC50	~	12	12.0	-10	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	20080636
	10079900	2531	None	0	Human	Functional	pIC50	=	10	10.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10748237
	6250	2531	None	0	Human	Functional	pIC50	=	10	10.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10748237
	1030	3761	None	0	Human	Functional	pIC50	=	5.2	5.2	-28	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10882119
	1030	3761	None	0	Human	Functional	pIC50	=	5.2	5.2	-28	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17687636
	1030	3761	None	0	Human	Functional	pIC50	=	5.2	5.2	-28	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	6280748
	1040	4094	None	0	Human	Functional	pIC50	=	6.6	6.6	4	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15210823
	6241	886	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19023040
	6263	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	23788657
	91827351	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	23788657
	CHEMBL3590218	1000	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	721	12	2	6	4.8	CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C	23788657
	1043	3012	None	0	Human	Functional	pIC50	None	7	7.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16025565

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	124093918	193798	None	0	Human	Binding	pEC50	=	10.7	10.7	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	420	4	2	5	3.0	COc1cc(F)c([C@@H]2CN3CCON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5271637	193798	None	0	Human	Binding	pEC50	=	10.7	10.7	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	420	4	2	5	3.0	COc1cc(F)c([C@@H]2CN3CCON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	118132792	181774	None	0	Human	Binding	pEC50	=	10.3	10.3	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	411	4	4	4	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4776349	181774	None	0	Human	Binding	pEC50	=	10.3	10.3	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	411	4	4	4	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122583080	182915	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	4	4	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4790836	182915	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	4	4	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	118132866	179814	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	343	4	3	3	2.2	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4743917	179814	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	343	4	3	3	2.2	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02101
	122583049	180812	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	395	4	4	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4755590	180812	None	0	Human	Binding	pEC50	=	10.1	10.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	395	4	4	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	118132864	179840	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4744094	179840	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	122582941	181105	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	395	4	3	3	3.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4758920	181105	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	395	4	3	3	3.0	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	135251225	182438	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	373	4	3	3	3.1	COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784400	182438	None	0	Human	Binding	pEC50	=	10.0	10.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	373	4	3	3	3.1	COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	122582915	194527	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	371	5	2	3	3.0	CCN1C[C@@H](c2ccc(OC)cc2)[C@H](NC(=O)Nc2ccc(F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5288361	194527	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	371	5	2	3	3.0	CCN1C[C@@H](c2ccc(OC)cc2)[C@H](NC(=O)Nc2ccc(F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	129227179	194359	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	512	6	3	4	4.7	CS(=O)(=O)Nc1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284349	194359	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	512	6	3	4	4.7	CS(=O)(=O)Nc1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	122583076	182189	None	2	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4781596	182189	None	2	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	118132901	179904	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F	10.1021/acs.jmedchem.9b02101
	CHEMBL4744835	179904	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F	10.1021/acs.jmedchem.9b02101
	122582993	181377	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	397	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4762030	181377	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	397	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	171352123	194243	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	416	8	3	6	3.4	COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5281870	194243	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	416	8	3	6	3.4	COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	118132864	179840	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4744094	179840	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	162659259	181339	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	439	4	3	3	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4761554	181339	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	439	4	3	3	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	156159258	193757	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	524	7	3	4	3.6	CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	CHEMBL5270733	193757	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	524	7	3	4	3.6	CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	124093849	183182	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	330	4	2	3	3.1	COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL4794375	183182	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	330	4	2	3	3.1	COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	124092254	194499	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	416	8	3	7	2.4	COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2nnn(CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5287715	194499	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	416	8	3	7	2.4	COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2nnn(CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	171349120	193860	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	450	8	4	6	2.2	COc1ccc(NC(=O)N[C@@H]2/C(=N/OCCO)NC[C@H]2c2c(F)cc(OC)cc2F)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5273168	193860	None	0	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	450	8	4	6	2.2	COc1ccc(NC(=O)N[C@@H]2/C(=N/OCCO)NC[C@H]2c2c(F)cc(OC)cc2F)cc1	10.1016/j.ejmech.2021.113167
	124093792	193972	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	398	4	2	5	2.3	COc1ccc([C@@H]2CN3C(=O)CON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5275581	193972	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	398	4	2	5	2.3	COc1ccc([C@@H]2CN3C(=O)CON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	122583133	181268	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	401	4	3	4	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4760897	181268	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	401	4	3	4	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122582929	181967	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	382	4	3	5	2.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4778725	181967	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	382	4	3	5	2.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122582983	180643	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	362	4	3	4	1.8	COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4753713	180643	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	362	4	3	4	1.8	COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	11024	688	None	24	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583126	179929	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4745044	179929	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	139454913	194529	None	0	Human	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	561	5	2	3	6.0	CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	CHEMBL5288386	194529	None	0	Human	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	561	5	2	3	6.0	CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	11024	688	None	24	Mouse	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Mouse	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Mouse	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	124092429	193923	None	0	Human	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	404	9	4	4	2.9	CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)/C(N)=N/OCCO)cc1	10.1016/j.ejmech.2021.113167
	153682974	193923	None	0	Human	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	404	9	4	4	2.9	CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)/C(N)=N/OCCO)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5274399	193923	None	0	Human	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	404	9	4	4	2.9	CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)/C(N)=N/OCCO)cc1	10.1016/j.ejmech.2021.113167
	124092220	193772	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	443	9	3	6	3.8	CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(N(C)CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5270974	193772	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	443	9	3	6	3.8	CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(N(C)CCO)n2)cc1	10.1016/j.ejmech.2021.113167
	122583080	182915	None	0	Mouse	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	4	4	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4790836	182915	None	0	Mouse	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	4	4	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	135239014	194447	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	422	7	4	3	3.0	N/C(=N\C(=O)CCO)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc(Cl)cc1	10.1016/j.ejmech.2021.113167
	140888225	194447	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	422	7	4	3	3.0	N/C(=N\C(=O)CCO)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc(Cl)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5286212	194447	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	422	7	4	3	3.0	N/C(=N\C(=O)CCO)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc(Cl)cc1	10.1016/j.ejmech.2021.113167
	156159233	194189	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	506	7	3	6	2.4	CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4cnc(Cl)cn4)C3=O)cc2)CCC1	10.1016/j.ejmech.2021.113167
	CHEMBL5280720	194189	None	0	Human	Binding	pEC50	=	9.2	9.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	506	7	3	6	2.4	CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4cnc(Cl)cn4)C3=O)cc2)CCC1	10.1016/j.ejmech.2021.113167
	122582964	180307	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	417	4	3	4	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4749577	180307	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	417	4	3	4	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	118132914	179698	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	386	4	3	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4742149	179698	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	386	4	3	4	2.2	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	71526099	182496	None	2	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL4785302	182496	None	2	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	122583009	181513	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	375	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL4763673	181513	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	375	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	122582974	179539	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4740375	179539	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	118132817	180431	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F	10.1021/acs.jmedchem.9b02101
	CHEMBL4751168	180431	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F	10.1021/acs.jmedchem.9b02101
	122592369	183126	None	0	Human	Binding	pEC50	=	9.0	9.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4793814	183126	None	0	Human	Binding	pEC50	=	9.0	9.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	118132868	181524	None	0	Human	Binding	pEC50	=	9.0	9.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4763824	181524	None	0	Human	Binding	pEC50	=	9.0	9.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	171352615	193980	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	448	6	2	4	3.9	COc1ccc([C@@H]2CCN(Cc3ccccn3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5275766	193980	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	448	6	2	4	3.9	COc1ccc([C@@H]2CCN(Cc3ccccn3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	171357377	194090	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	448	6	2	4	3.9	COc1ccc([C@H]2CCN(Cc3cccnc3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5278464	194090	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	448	6	2	4	3.9	COc1ccc([C@H]2CCN(Cc3cccnc3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1	10.1016/j.ejmech.2021.113167
	171347467	194446	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	473	7	2	3	5.3	COc1cc(F)c([C@H]2CCN(CCC(F)F)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5286200	194446	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	473	7	2	3	5.3	COc1cc(F)c([C@H]2CCN(CCC(F)F)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1	10.1016/j.ejmech.2021.113167
	171358475	194598	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	437	5	2	5	4.3	COc1ccc([C@H]2CCN(c3ccnnc3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5290016	194598	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay	ChEMBL	437	5	2	5	4.3	COc1ccc([C@H]2CCN(c3ccnnc3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1016/j.ejmech.2021.113167
	122583086	182183	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	378	4	4	3	2.5	CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4781488	182183	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	378	4	4	3	2.5	CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122583133	181268	None	0	Mouse	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	401	4	3	4	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4760897	181268	None	0	Mouse	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	401	4	3	4	3.1	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122583076	182189	None	2	Mouse	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4781596	182189	None	2	Mouse	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122583163	179756	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	357	4	3	3	2.5	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4743084	179756	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	357	4	3	3	2.5	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1	10.1021/acs.jmedchem.9b02101
	118132940	182875	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	402	4	3	5	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4790245	182875	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	402	4	3	5	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122583150	194260	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	380	3	3	4	2.0	N#Cc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2cc3c(cc2F)OCC3)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5282261	194260	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	380	3	3	4	2.0	N#Cc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2cc3c(cc2F)OCC3)cc1	10.1016/j.ejmech.2021.113167
	150982132	193570	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	464	4	3	3	3.0	Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Br)cc3F)CC2)n1	10.1016/j.ejmech.2021.113167
	CHEMBL5265888	193570	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	464	4	3	3	3.0	Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Br)cc3F)CC2)n1	10.1016/j.ejmech.2021.113167
	147076362	193733	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	475	4	2	4	3.8	CN1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	CHEMBL5270218	193733	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	475	4	2	4	3.8	CN1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	154971628	193876	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	474	4	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5273483	193876	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	474	4	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	44413534	138466	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	CHEMBL377226	138466	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	154971434	194051	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	503	4	2	4	3.7	CC(=O)N1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	CHEMBL5277650	194051	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	503	4	2	4	3.7	CC(=O)N1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	152203565	194227	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	420	4	3	3	2.9	Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Cl)cc3F)CC2)n1	10.1016/j.ejmech.2021.113167
	CHEMBL5281612	194227	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	420	4	3	3	2.9	Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Cl)cc3F)CC2)n1	10.1016/j.ejmech.2021.113167
	139454908	193631	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	565	6	3	4	4.8	CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	CHEMBL5267353	193631	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	565	6	3	4	4.8	CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	162644272	181935	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	345	4	3	3	2.7	COc1ccc([C@@H]2NC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4778312	181935	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	345	4	3	3	2.7	COc1ccc([C@@H]2NC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	171352328	194112	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	451	5	1	5	4.1	COc1cccc(-c2cc(C#N)c(C)n(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5278883	194112	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	451	5	1	5	4.1	COc1cccc(-c2cc(C#N)c(C)n(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	71525547	194577	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5289577	194577	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	11024	688	None	24	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	122583088	688	None	24	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	CHEMBL4784510	688	None	24	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	171345903	194380	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn([C@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5284927	194380	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn([C@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	171345614	194354	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	455	6	1	5	3.9	COc1ccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284145	194354	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	455	6	1	5	3.9	COc1ccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1	10.1016/j.ejmech.2021.113167
	11024	688	None	24	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	162676377	183453	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4797594	183453	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	402	4	3	3	3.9	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1	10.1016/j.ejmech.2021.113194
	162663800	182022	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	402	6	3	3	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4779558	182022	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	402	6	3	3	3.8	O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	122582973	180885	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	393	5	3	3	2.9	CCOc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4756320	180885	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	393	5	3	3	2.9	CCOc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	162649751	180195	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4748148	180195	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1	10.1016/j.ejmech.2021.113194
	162432252	194140	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	517	7	1	5	5.2	COc1cccc(Cc2c(-c3ccccc3)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5279627	194140	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	517	7	1	5	5.2	COc1cccc(Cc2c(-c3ccccc3)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	122487986	176078	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	CHEMBL4588649	176078	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	171352337	194128	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5279215	194128	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	142493593	193574	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	483	6	2	5	3.4	O=C(Nc1ccc(Cl)cn1)N[C@@H]1CCCN(c2ccc(C3(CN4CCOCC4)CC3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5265951	193574	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	483	6	2	5	3.4	O=C(Nc1ccc(Cl)cn1)N[C@@H]1CCCN(c2ccc(C3(CN4CCOCC4)CC3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	156159245	193879	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	525	7	4	6	1.7	CS(=O)(=O)NCC1(c2ccc(N3C[C@@H](O)C[C@@H](NC(=O)Nc4ncc(Cl)cc4F)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	CHEMBL5273627	193879	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	525	7	4	6	1.7	CS(=O)(=O)NCC1(c2ccc(N3C[C@@H](O)C[C@@H](NC(=O)Nc4ncc(Cl)cc4F)C3=O)cc2)CC1	10.1016/j.ejmech.2021.113167
	142493671	194373	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	595	7	3	6	4.6	COc1cc(-c2ccccc2NS(C)(=O)=O)ccc1N1CCC[C@@H](NC(=O)Nc2ncc(C(F)(F)F)cc2F)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5284802	194373	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	595	7	3	6	4.6	COc1cc(-c2ccccc2NS(C)(=O)=O)ccc1N1CCC[C@@H](NC(=O)Nc2ncc(C(F)(F)F)cc2F)C1=O	10.1016/j.ejmech.2021.113167
	171350148	193576	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5265989	193576	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1	10.1016/j.ejmech.2021.113167
	162663817	182034	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	419	4	3	4	3.6	Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4779714	182034	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	419	4	3	4	3.6	Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1	10.1016/j.ejmech.2021.113194
	71362579	170983	None	5	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assayAgonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assay	ChEMBL	856	26	10	11	1.8	CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL4454321	170983	None	5	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assayAgonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assay	ChEMBL	856	26	10	11	1.8	CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O	10.1021/acs.jmedchem.8b00435
	162654865	180681	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	433	5	3	4	3.8	Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4754119	180681	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	433	5	3	4	3.8	Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	122583009	181513	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	375	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4763673	181513	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	375	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	171355428	193913	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assay	ChEMBL	427	7	0	8	4.1	Cc1cccc(-c2oc(C)nc2C(=O)Cc2cnn(Cc3nc(C(C)(F)F)co3)n2)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5274258	193913	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assay	ChEMBL	427	7	0	8	4.1	Cc1cccc(-c2oc(C)nc2C(=O)Cc2cnn(Cc3nc(C(C)(F)F)co3)n2)c1	10.1016/j.ejmech.2021.113167
	124093810	194546	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	398	3	2	6	2.5	O=C(Nc1ccc(F)cc1)N[C@@H]1c2nnnn2C[C@H]1c1cc2c(cc1F)OCC2	10.1016/j.ejmech.2021.113167
	CHEMBL5288663	194546	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux	ChEMBL	398	3	2	6	2.5	O=C(Nc1ccc(F)cc1)N[C@@H]1c2nnnn2C[C@H]1c1cc2c(cc1F)OCC2	10.1016/j.ejmech.2021.113167
	139455056	194028	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	523	5	2	4	5.5	CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3csc(Cl)c3)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	CHEMBL5276954	194028	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	523	5	2	4	5.5	CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3csc(Cl)c3)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	162645753	179618	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	444	6	3	3	4.9	O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4741207	179618	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	444	6	3	3	4.9	O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	142493665	194116	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	512	6	3	6	3.3	Cc1cnc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4NS(C)(=O)=O)cc3F)C2=O)cn1	10.1016/j.ejmech.2021.113167
	CHEMBL5278986	194116	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	512	6	3	6	3.3	Cc1cnc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4NS(C)(=O)=O)cc3F)C2=O)cn1	10.1016/j.ejmech.2021.113167
	126520336	194016	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5276622	194016	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	385	7	4	3	2.2	CC(C)C[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	162664348	182271	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	318	5	2	2	4.1	COc1ccc(CC(C)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4782531	182271	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	318	5	2	2	4.1	COc1ccc(CC(C)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	171347985	194375	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284816	194375	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	171348232	194350	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	517	5	2	3	5.5	CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	CHEMBL5284060	194350	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	517	5	2	3	5.5	CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F	10.1016/j.ejmech.2021.113167
	162657722	181248	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	436	4	3	3	4.6	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4760670	181248	None	0	Human	Binding	pEC50	=	5.6	5.6	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	436	4	3	3	4.6	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1	10.1016/j.ejmech.2021.113194
	171352074	194193	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	459	9	4	4	4.0	COc1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5280794	194193	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	459	9	4	4	4.0	COc1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	154971347	194508	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	460	4	2	3	5.0	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CCCCC3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5287909	194508	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	460	4	2	3	5.0	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CCCCC3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	162673503	183106	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	365	3	3	2	3.0	O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F	10.1021/acs.jmedchem.9b02101
	CHEMBL4793557	183106	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	365	3	3	2	3.0	O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F	10.1021/acs.jmedchem.9b02101
	122582962	182818	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	5	3	4	2.4	COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4789579	182818	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	391	5	3	4	2.4	COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1	10.1021/acs.jmedchem.9b02101
	11024	688	None	24	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	71526008	194390	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	403	7	4	3	2.3	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1F)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5285150	194390	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay	ChEMBL	403	7	4	3	2.3	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1F)C(=O)NCC(=O)O	10.1016/j.ejmech.2021.113167
	162674826	183362	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	347	6	3	3	2.6	COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(N)=O)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4796468	183362	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	347	6	3	3	2.6	COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(N)=O)cc1	10.1021/acs.jmedchem.9b02101
	126520434	194024	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	371	7	4	3	1.9	CCC[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5276878	194024	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	371	7	4	3	1.9	CCC[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	124092285	181624	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	348	6	3	3	3.2	COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(=O)O)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4765025	181624	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	348	6	3	3	3.2	COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(=O)O)cc1	10.1021/acs.jmedchem.9b02101
	44413534	138466	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assayAgonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	CHEMBL377226	138466	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assayAgonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	171347985	194375	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284816	194375	None	0	Human	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	142493804	194035	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	481	6	3	4	3.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3ccc4cc(OC)ccc4c3)CC2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5277178	194035	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	481	6	3	4	3.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3ccc4cc(OC)ccc4c3)CC2)c(F)c1	10.1016/j.ejmech.2021.113167
	118132917	183108	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4793603	183108	None	0	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	126520512	194169	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	419	7	4	3	2.4	O=C(CNC(=O)Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5280317	194169	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	419	7	4	3	2.4	O=C(CNC(=O)Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/j.ejmech.2021.113167
	154971329	193744	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	475	4	2	5	3.3	O=C(Nc1ccc(C(F)(F)F)cn1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5270501	193744	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	475	4	2	5	3.3	O=C(Nc1ccc(C(F)(F)F)cn1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	11024	688	None	24	Mouse	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	122583088	688	None	24	Mouse	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	CHEMBL4784510	688	None	24	Mouse	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1016/j.ejmech.2021.113167
	139454961	194516	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	499	5	2	4	4.9	O=C(Nc1ccc(Cl)cc1F)N[C@@H]1CCN(c2ccc(-c3cnn(C(F)F)c3)c(F)c2F)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5288141	194516	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	499	5	2	4	4.9	O=C(Nc1ccc(Cl)cc1F)N[C@@H]1CCN(c2ccc(-c3cnn(C(F)F)c3)c(F)c2F)C1=O	10.1016/j.ejmech.2021.113167
	118132818	179759	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	377	4	3	3	2.9	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4743133	179759	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	377	4	3	3	2.9	COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1	10.1021/acs.jmedchem.9b02101
	124092513	194249	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	334	6	3	3	3.1	COc1ccc(C[C@H](CO)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5282051	194249	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay	ChEMBL	334	6	3	3	3.1	COc1ccc(C[C@H](CO)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1016/j.ejmech.2021.113167
	122582903	182989	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	396	4	3	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4792002	182989	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	396	4	3	4	2.4	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1	10.1021/acs.jmedchem.9b02101
	122582974	179539	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4740375	179539	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	359	4	3	3	2.8	COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	146520179	193771	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	497	5	3	3	5.4	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5270967	193771	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	497	5	3	3	5.4	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O	10.1016/j.ejmech.2021.113167
	129227135	193799	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	496	5	3	3	4.8	NC(=O)c1ccccc1-c1ccc(N2CCCC(NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5271664	193799	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	496	5	3	3	4.8	NC(=O)c1ccccc1-c1ccc(N2CCCC(NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	129226626	194033	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	421	4	2	2	4.9	O=C(Nc1ccccc1F)N[C@@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5277119	194033	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	421	4	2	2	4.9	O=C(Nc1ccccc1F)N[C@@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	129226995	194089	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	471	4	2	2	5.8	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5278412	194089	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	471	4	2	2	5.8	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O	10.1016/j.ejmech.2021.113167
	129227194	194505	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	496	5	3	3	4.8	NC(=O)c1ccccc1-c1ccc(N2CCC[C@H](NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5287828	194505	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	496	5	3	3	4.8	NC(=O)c1ccccc1-c1ccc(N2CCC[C@H](NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	24776341	3239	None	34	Human	Binding	pEC50	=	7.4	7.4	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	5831	3239	None	34	Human	Binding	pEC50	=	7.4	7.4	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	CHEMBL379761	3239	None	34	Human	Binding	pEC50	=	7.4	7.4	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	384	4	2	4	4.6	O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.8b01912
	171354628	194248	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	459	9	4	4	4.0	COc1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5282050	194248	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	459	9	4	4	4.0	COc1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	162659418	181340	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	433	5	3	4	4.3	CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4761559	181340	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	433	5	3	4	4.3	CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	162671881	182950	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	432	5	3	4	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4791407	182950	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	432	5	3	4	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1	10.1016/j.ejmech.2021.113194
	162645814	179742	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	404	6	3	3	4.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	CHEMBL4742937	179742	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	404	6	3	3	4.0	CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1	10.1016/j.ejmech.2021.113194
	122582886	183454	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2F)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4797598	183454	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	379	4	3	3	2.5	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2F)c(F)c1	10.1021/acs.jmedchem.9b02101
	171342877	193796	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	455	6	1	5	3.9	COc1cccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5271505	193796	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay	ChEMBL	455	6	1	5	3.9	COc1cccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1	10.1016/j.ejmech.2021.113167
	129226957	194535	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	446	5	3	3	3.9	NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5288471	194535	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	446	5	3	3	3.9	NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(F)cc3)C2=O)cc1	10.1016/j.ejmech.2021.113167
	142493808	194300	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	469	5	3	3	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3cccc(C(F)(F)F)c3)CC2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5283221	194300	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	469	5	3	3	3.6	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3cccc(C(F)(F)F)c3)CC2)c(F)c1	10.1016/j.ejmech.2021.113167
	129226980	194277	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	497	5	3	3	5.4	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5282707	194277	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	497	5	3	3	5.4	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O	10.1016/j.ejmech.2021.113167
	122582977	182389	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	377	4	3	2	3.1	CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4783963	182389	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	377	4	3	2	3.1	CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	44413534	138466	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	CHEMBL377226	138466	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	398	3	2	4	4.8	Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1	10.1016/j.ejmech.2021.113167
	162673364	183105	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	394	5	4	3	2.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4793549	183105	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	394	5	4	3	2.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1	10.1016/j.ejmech.2021.113194
	154971626	193889	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	474	4	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	CHEMBL5273815	193889	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	474	4	2	4	3.9	O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O	10.1016/j.ejmech.2021.113167
	126520480	194379	None	0	Human	Binding	pEC50	=	5.3	5.3	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	399	8	4	3	2.6	CC(C)C[C@H](NC(=O)CCNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	CHEMBL5284903	194379	None	0	Human	Binding	pEC50	=	5.3	5.3	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	399	8	4	3	2.6	CC(C)C[C@H](NC(=O)CCNC(=O)Nc1ccc(Br)cc1)C(=O)O	10.1016/j.ejmech.2021.113167
	139455053	194346	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	547	5	2	5	4.9	CC1(C)CN(c2ccc(-c3ccccc3P(C)(C)=O)c(F)c2F)C(=O)[C@@H]1NC(=O)Nc1cnc(Cl)cn1	10.1016/j.ejmech.2021.113167
	CHEMBL5283999	194346	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	547	5	2	5	4.9	CC1(C)CN(c2ccc(-c3ccccc3P(C)(C)=O)c(F)c2F)C(=O)[C@@H]1NC(=O)Nc1cnc(Cl)cn1	10.1016/j.ejmech.2021.113167
	124092515	181230	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	334	6	3	3	3.1	COc1ccc(CC(CO)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4760555	181230	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	334	6	3	3	3.1	COc1ccc(CC(CO)NC(=O)Nc2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.9b02101
	146035589	173833	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4536334	173833	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	483	10	1	6	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O	10.1021/acs.jmedchem.8b01912
	162660629	181373	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4761978	181373	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	417	5	3	4	3.6	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	146035588	170999	None	2	Human	Binding	pEC50	=	7.2	7.2	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	CHEMBL4454594	170999	None	2	Human	Binding	pEC50	=	7.2	7.2	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	453	9	1	5	5.2	CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O	10.1021/acs.jmedchem.8b01912
	171349638	193651	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5267880	193651	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1	10.1016/j.ejmech.2021.113167
	171356459	193902	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5274109	193902	None	0	Human	Binding	pEC50	=	5.2	5.2	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	484	9	4	5	3.9	COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1	10.1016/j.ejmech.2021.113167
	162425411	193888	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	547	7	2	8	4.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Oc4ccc(C(F)(F)F)nc4)cc3)o2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5273792	193888	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	547	7	2	8	4.9	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Oc4ccc(C(F)(F)F)nc4)cc3)o2)c(F)c1	10.1016/j.ejmech.2021.113167
	162653376	180491	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	403	4	3	4	3.3	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4751781	180491	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	403	4	3	4	3.3	O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1	10.1016/j.ejmech.2021.113194
	162660631	181383	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	5	3	3	4.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4762142	181383	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	5	3	3	4.2	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1	10.1016/j.ejmech.2021.113194
	162653824	180594	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	447	6	3	4	4.5	CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4753061	180594	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	447	6	3	4	4.5	CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1	10.1016/j.ejmech.2021.113194
	129226959	194002	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	492	6	3	4	4.4	COc1ccc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4C(N)=O)cc3)C2=O)cc1Cl	10.1016/j.ejmech.2021.113167
	CHEMBL5276320	194002	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	492	6	3	4	4.4	COc1ccc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4C(N)=O)cc3)C2=O)cc1Cl	10.1016/j.ejmech.2021.113167
	162655466	180900	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	388	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1	10.1016/j.ejmech.2021.113194
	CHEMBL4756434	180900	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	388	5	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1	10.1016/j.ejmech.2021.113194
	122582993	181377	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	397	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4762030	181377	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	397	4	3	3	2.7	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1	10.1021/acs.jmedchem.9b02101
	171347985	194375	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284816	194375	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	162425431	194641	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	435	6	2	5	4.3	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(C(F)F)cc3)on2)c(F)c1	10.1016/j.ejmech.2021.113167
	CHEMBL5291461	194641	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay	ChEMBL	435	6	2	5	4.3	COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(C(F)F)cc3)on2)c(F)c1	10.1016/j.ejmech.2021.113167
	171346443	194421	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	399	4	2	4	2.6	O=C(Cn1c(=O)[nH]cc(-c2ccccc2)c1=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5285738	194421	None	0	Human	Binding	pEC50	=	5.1	5.1	-	0	Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis	ChEMBL	399	4	2	4	2.6	O=C(Cn1c(=O)[nH]cc(-c2ccccc2)c1=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	122582965	181043	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	374	3	3	3	2.4	N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	CHEMBL4758129	181043	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	374	3	3	3	2.4	N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1	10.1021/acs.jmedchem.9b02101
	162658091	181158	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	423	6	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1	10.1016/j.ejmech.2021.113194
	CHEMBL4759517	181158	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	423	6	3	3	3.4	O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1	10.1016/j.ejmech.2021.113194
	122487986	176078	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	CHEMBL4588649	176078	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay	ChEMBL	411	6	1	5	4.0	COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1	10.1021/acs.jmedchem.8b01912
	162644943	179507	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	4	3	3	4.2	Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1	10.1016/j.ejmech.2021.113194
	CHEMBL4739971	179507	None	0	Human	Binding	pEC50	=	5.0	5.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	4	3	3	4.2	Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1	10.1016/j.ejmech.2021.113194
	6268	310	None	3	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.9b02101
	727787	310	None	3	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.9b02101
	CHEMBL1289260	310	None	3	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method	ChEMBL	304	5	2	2	3.7	COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl	10.1021/acs.jmedchem.9b02101
	162672626	183194	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	4	3	3	4.2	Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	CHEMBL4794472	183194	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay	ChEMBL	416	4	3	3	4.2	Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1	10.1016/j.ejmech.2021.113194
	171347985	194375	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	CHEMBL5284816	194375	None	0	Human	Binding	pEC50	=	5	5.0	-	0	Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay	ChEMBL	342	5	3	2	3.3	CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2021.113167
	134263912	170009	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	10	10.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	153047598	175469	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	153047597	171534	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	134264894	169721	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4436717	169721	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	153047597	171534	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	153047597	171534	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	10138	39	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264089	39	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4536276	39	None	0	Human	Binding	pIC50	=	9	9.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	153047598	175469	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	1034	2392	None	22	Human	Binding	pIC50	=	8.8	8.8	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	8.8	8.8	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	8.8	8.8	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	1034	2392	None	22	Human	Binding	pIC50	=	8.7	8.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	8.7	8.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	8.7	8.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	153047598	175469	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	137650732	157396	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2285	73	13	21	12.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4077102	157396	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2285	73	13	21	12.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	1034	2392	None	22	Human	Binding	pIC50	=	7.9	7.9	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	7.9	7.9	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	7.9	7.9	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	137657539	159885	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1524	61	23	17	-1.2	CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00489
	CHEMBL4105404	159885	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1524	61	23	17	-1.2	CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00489
	153047597	171534	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	137631898	156495	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1599	51	9	15	9.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4066521	156495	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1599	51	9	15	9.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	137647141	157711	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2177	73	13	21	11.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4081147	157711	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2177	73	13	21	11.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	137644238	158535	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1888	62	11	18	10.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4090485	158535	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1888	62	11	18	10.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	153047598	175469	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	134263912	170009	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134265014	169621	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	134263912	170009	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	8.6	8.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	1034	2392	None	22	Human	Binding	pIC50	=	7.7	7.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	7.7	7.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	7.7	7.7	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	137636433	156149	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	13.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4062611	156149	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	13.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	134263912	170009	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	153047598	175469	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	1034	2392	None	22	Human	Binding	pIC50	=	7.6	7.6	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	7.6	7.6	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	7.6	7.6	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	134275888	171383	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@H](C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4460558	171383	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@H](C)O	10.1016/j.ejmech.2018.10.049
	155546686	173740	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4534051	173740	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O	10.1016/j.ejmech.2018.10.049
	137653536	158867	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1021	29	5	9	7.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4094101	158867	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1021	29	5	9	7.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	137645526	157814	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1310	40	7	12	8.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4082093	157814	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1310	40	7	12	8.1	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	134265014	169621	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	134264414	174469	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134263912	170009	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134264894	169721	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4436717	169721	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134264414	174469	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	155546686	173740	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4534051	173740	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	326	8	3	7	0.9	COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O	10.1016/j.ejmech.2018.10.049
	134265014	169621	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	134264894	169721	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4436717	169721	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	153047597	171534	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	137634576	156136	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	14.5	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4062488	156136	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	14.5	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	137639628	157011	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2467	84	15	24	12.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4072333	157011	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2467	84	15	24	12.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	155561936	175835	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4582724	175835	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	153047597	171534	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4462922	171534	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	134264414	174469	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	10138	39	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264089	39	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4536276	39	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264414	174469	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134264414	174469	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	137638855	157072	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2756	95	17	27	13.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4073052	157072	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2756	95	17	27	13.2	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL3588930	214264	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1	10.1021/acs.jmedchem.7b00489
	137639605	156993	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	14.5	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4072201	156993	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2261	73	13	21	14.5	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	10138	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264089	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4536276	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134265014	169621	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	10138	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264089	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4536276	39	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL3588930	214264	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Allosteric antagonist activity against FPR2 (unknown origin)Allosteric antagonist activity against FPR2 (unknown origin)	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1	10.1016/j.bmc.2015.03.062
	137651557	157571	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2501	73	13	21	13.7	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4079416	157571	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2501	73	13	21	13.7	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	134264414	174469	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4551559	174469	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	11024	688	None	24	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	122583088	688	None	24	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	CHEMBL4784510	688	None	24	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay	ChEMBL	361	4	3	3	2.4	COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1	10.1021/acs.jmedchem.9b02101
	134264894	169721	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4436717	169721	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	354	10	3	7	1.6	CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	155561936	175835	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4582724	175835	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	134265014	169621	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	155561936	175835	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4582724	175835	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	16143873	159706	None	1	Human	Binding	pIC50	=	7.2	7.2	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay	ChEMBL	1712	54	23	19	-0.6	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4103322	159706	None	1	Human	Binding	pIC50	=	7.2	7.2	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay	ChEMBL	1712	54	23	19	-0.6	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	134263912	170009	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	CHEMBL4440913	170009	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C	10.1016/j.ejmech.2018.10.049
	134265014	169621	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	CHEMBL4434857	169621	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay	ChEMBL	459	14	3	7	4.8	CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C	10.1016/j.ejmech.2018.10.049
	153047598	175469	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	CHEMBL4574711	175469	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	506	14	3	7	5.2	CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC	10.1016/j.ejmech.2018.10.049
	1034	2392	None	22	Human	Binding	pIC50	=	8.1	8.1	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	5280914	2392	None	22	Human	Binding	pIC50	=	8.1	8.1	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	CHEMBL392438	2392	None	22	Human	Binding	pIC50	=	8.1	8.1	1	2	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	10.1016/j.ejmech.2018.10.049
	137632100	156557	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	731	18	3	6	6.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4067361	156557	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	731	18	3	6	6.0	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	10138	39	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	134264089	39	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	CHEMBL4536276	39	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay	ChEMBL	382	12	3	7	2.4	CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O	10.1016/j.ejmech.2018.10.049
	137645180	158017	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1524	61	23	17	-1.2	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00489
	CHEMBL4084411	158017	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	1524	61	23	17	-1.2	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00489
	137647209	157855	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2585	73	13	21	17.3	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	CHEMBL4082656	157855	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay	ChEMBL	2585	73	13	21	17.3	CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1	10.1021/acs.jmedchem.7b00489
	1048	4085	None	0	Human	Binding	pKd	=	10.1	10.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10586077
	1048	4085	None	0	Human	Binding	pKd	=	10.1	10.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11035102
	1048	4085	None	0	Human	Binding	pKd	=	10.1	10.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11285256
	1048	4085	None	0	Human	Binding	pKd	=	10.1	10.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	23160941
	1022	1669	None	42	Human	Binding	pKd	=	6.4	6.4	-38	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8349692
	443295	1669	None	42	Human	Binding	pKd	=	6.4	6.4	-38	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8349692
	CHEMBL267179	1669	None	42	Human	Binding	pKd	=	6.4	6.4	-38	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8349692
	1031	423	None	0	Human	Binding	pKd	=	6.5	6.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12368905
	1034	2392	None	22	Mouse	Binding	pKd	=	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	9151906
	5280914	2392	None	22	Mouse	Binding	pKd	=	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	9151906
	CHEMBL392438	2392	None	22	Mouse	Binding	pKd	=	8.8	8.8	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	9151906
	1034	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	1322894
	1034	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	8006586
	5280914	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	1322894
	5280914	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	8006586
	CHEMBL392438	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	1322894
	CHEMBL392438	2392	None	22	Human	Binding	pKd	=	9.0	9.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	352	14	4	4	3.1	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O	8006586
	6241	886	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19023040

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