Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| CHEMBL1893324 | 211519 | None | 20 | Human | Functional | pEC50 | = | 10.7 | 10.7 | 1 | 3 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1021/acs.jmedchem.0c01396 | |||||
| 168299476 | 192855 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | -1 | 3 | ChEMBL | 4660 | 165 | 74 | 67 | -19.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.0c01396 | |||
| CHEMBL5220770 | 192855 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | -1 | 3 | ChEMBL | 4660 | 165 | 74 | 67 | -19.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O | 10.1021/acs.jmedchem.0c01396 | |||
| CHEMBL4294827 | 215993 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)NC(CC(N)=O)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | nan | |||||
| CHEMBL4280734 | 215870 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 223 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| 2263 | 257 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| 44566111 | 257 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| CHEMBL219499 | 257 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 3 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| CHEMBL4295255 | 215996 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4282016 | 215889 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -204 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O | nan | |||||
| CHEMBL4277870 | 215842 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1659 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4282364 | 215892 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1071 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NC(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4287451 | 215930 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -426 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(CCC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4295255 | 215996 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4277441 | 215832 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1202 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4286419 | 215924 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -234 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4281814 | 215885 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 58 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4290756 | 215962 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O | nan | |||||
| CHEMBL4277709 | 215838 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 870 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4277799 | 215841 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -977 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4284839 | 215909 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 11 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CC(CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4281905 | 215887 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4291903 | 215972 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -660 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O | nan | |||||
| CHEMBL4282941 | 215895 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4294843 | 215994 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 11 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)NC(CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4291119 | 215967 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 2 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(CCCCN)CC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C | nan | |||||
| CHEMBL4277783 | 215840 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CC(CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C | nan | |||||
| CHEMBL4284961 | 215912 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -9 | 2 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CC(Cc1ccc(O)cc1)NC(=O)CC(CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O | nan | |||||
| 57395756 | 71237 | None | 0 | Rat | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 316 | 3 | 1 | 1 | 5.9 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(Cl)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956426 | 71237 | None | 0 | Rat | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 316 | 3 | 1 | 1 | 5.9 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(Cl)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 57399212 | 71245 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956434 | 71245 | None | 0 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 11570626 | 2550 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -707 | 8 | ChEMBL | 587 | 9 | 2 | 5 | 7.5 | COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl | 10.1021/jm300579z | |||
| 9135 | 2550 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -707 | 8 | ChEMBL | 587 | 9 | 2 | 5 | 7.5 | COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl | 10.1021/jm300579z | |||
| CHEMBL1933349 | 2550 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -707 | 8 | ChEMBL | 587 | 9 | 2 | 5 | 7.5 | COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl | 10.1021/jm300579z | |||
| DB12044 | 2550 | None | 32 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -707 | 8 | ChEMBL | 587 | 9 | 2 | 5 | 7.5 | COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl | 10.1021/jm300579z | |||
| 168298339 | 192818 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -33 | 3 | ChEMBL | 4137 | 147 | 67 | 59 | -16.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C | 10.1021/acs.jmedchem.0c01396 | |||
| CHEMBL5219662 | 192818 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -33 | 3 | ChEMBL | 4137 | 147 | 67 | 59 | -16.2 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C | 10.1021/acs.jmedchem.0c01396 | |||
| 57395755 | 71236 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 332 | 3 | 1 | 1 | 6.4 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc3ccccc3c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956425 | 71236 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 332 | 3 | 1 | 1 | 6.4 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc3ccccc3c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 19220887 | 71250 | None | 1 | Rat | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 344 | 4 | 1 | 3 | 4.7 | N#Cc1c(NC(=O)CCc2ccc(Cl)cc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956439 | 71250 | None | 1 | Rat | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 344 | 4 | 1 | 3 | 4.7 | N#Cc1c(NC(=O)CCc2ccc(Cl)cc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 810647 | 71239 | None | 40 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 234 | 2 | 1 | 3 | 2.8 | CCC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956428 | 71239 | None | 40 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 234 | 2 | 1 | 3 | 2.8 | CCC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57402730 | 71254 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 336 | 2 | 1 | 3 | 4.2 | N#Cc1c(NC(=O)C2CCc3ccccc3C2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956443 | 71254 | None | 0 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 336 | 2 | 1 | 3 | 4.2 | N#Cc1c(NC(=O)C2CCc3ccccc3C2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57399163 | 71225 | None | 0 | Rat | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956414 | 71225 | None | 0 | Rat | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| 290230 | 32618 | None | 28 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 220 | 1 | 1 | 3 | 2.5 | CC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1412798 | 32618 | None | 28 | Rat | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 220 | 1 | 1 | 3 | 2.5 | CC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 290221 | 87286 | None | 25 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 282 | 2 | 1 | 3 | 3.8 | N#Cc1c(NC(=O)c2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL233000 | 87286 | None | 25 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 282 | 2 | 1 | 3 | 3.8 | N#Cc1c(NC(=O)c2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 684674 | 152642 | None | 18 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 296 | 3 | 1 | 3 | 3.7 | N#Cc1c(NC(=O)Cc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL397167 | 152642 | None | 18 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 296 | 3 | 1 | 3 | 3.7 | N#Cc1c(NC(=O)Cc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57402678 | 71224 | None | 0 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 328 | 4 | 1 | 2 | 6.0 | CSc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956413 | 71224 | None | 0 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 328 | 4 | 1 | 2 | 6.0 | CSc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57399214 | 71255 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 322 | 2 | 1 | 3 | 3.9 | N#Cc1c(NC(=O)C2Cc3ccccc3C2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956444 | 71255 | None | 0 | Rat | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 322 | 2 | 1 | 3 | 3.9 | N#Cc1c(NC(=O)C2Cc3ccccc3C2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57399211 | 71235 | None | 0 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 332 | 3 | 1 | 1 | 6.4 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc3ccccc23)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956424 | 71235 | None | 0 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 332 | 3 | 1 | 1 | 6.4 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc3ccccc23)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 57390453 | 71242 | None | 1 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 260 | 2 | 1 | 3 | 3.2 | N#Cc1c(NC(=O)C2CCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956431 | 71242 | None | 1 | Rat | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 260 | 2 | 1 | 3 | 3.2 | N#Cc1c(NC(=O)C2CCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 800118 | 71240 | None | 3 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 262 | 3 | 1 | 3 | 3.5 | CC(C)CC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956429 | 71240 | None | 3 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 262 | 3 | 1 | 3 | 3.5 | CC(C)CC(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57395758 | 71251 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 352 | 3 | 1 | 4 | 4.9 | N#Cc1c(NC(=O)Cc2cc3ccccc3s2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956440 | 71251 | None | 0 | Rat | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 352 | 3 | 1 | 4 | 4.9 | N#Cc1c(NC(=O)Cc2cc3ccccc3s2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57395679 | 71223 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956412 | 71223 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57393989 | 71234 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(-c3ccccc3)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956423 | 71234 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(-c3ccccc3)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 57397531 | 71233 | None | 0 | Rat | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 296 | 3 | 1 | 1 | 5.6 | Cc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956422 | 71233 | None | 0 | Rat | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 296 | 3 | 1 | 1 | 5.6 | Cc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| 694422 | 71241 | None | 25 | Rat | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 1 | 3 | 2.8 | N#Cc1c(NC(=O)C2CC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956430 | 71241 | None | 25 | Rat | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 246 | 2 | 1 | 3 | 2.8 | N#Cc1c(NC(=O)C2CC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57399210 | 71232 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 316 | 3 | 1 | 1 | 5.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(Cl)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956421 | 71232 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 316 | 3 | 1 | 1 | 5.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(Cl)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 767327 | 71244 | None | 30 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 310 | 4 | 1 | 3 | 4.1 | N#Cc1c(NC(=O)CCc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956433 | 71244 | None | 30 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 310 | 4 | 1 | 3 | 4.1 | N#Cc1c(NC(=O)CCc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57393988 | 71231 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 296 | 3 | 1 | 1 | 5.6 | Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956420 | 71231 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 296 | 3 | 1 | 1 | 5.6 | Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57395754 | 71230 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 325 | 4 | 1 | 2 | 5.3 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(N(C)C)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956419 | 71230 | None | 0 | Rat | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 325 | 4 | 1 | 2 | 5.3 | CC(C)c1cc(C(C)(C)C)cc(-c2cccc(N(C)C)c2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 57400888 | 71217 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2-c2ccccc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956259 | 71217 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2-c2ccccc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 729610 | 56451 | None | 7 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 248 | 2 | 1 | 3 | 3.1 | CC(C)C(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1632048 | 56451 | None | 7 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 248 | 2 | 1 | 3 | 3.1 | CC(C)C(=O)Nc1sc2c(c1C#N)CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57400972 | 71252 | None | 0 | Rat | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 338 | 3 | 1 | 4 | 3.8 | N#Cc1c(NC(=O)CC2Cc3ccccc3O2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956441 | 71252 | None | 0 | Rat | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 338 | 3 | 1 | 4 | 3.8 | N#Cc1c(NC(=O)CC2Cc3ccccc3O2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57397476 | 71229 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 282 | 3 | 1 | 1 | 5.3 | CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956418 | 71229 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 282 | 3 | 1 | 1 | 5.3 | CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 4625719 | 71249 | None | 8 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 340 | 5 | 1 | 4 | 4.1 | COc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956438 | 71249 | None | 8 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 340 | 5 | 1 | 4 | 4.1 | COc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| 4578060 | 71243 | None | 6 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 274 | 2 | 1 | 3 | 3.6 | N#Cc1c(NC(=O)C2CCCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956432 | 71243 | None | 6 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 274 | 2 | 1 | 3 | 3.6 | N#Cc1c(NC(=O)C2CCCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 847353 | 152016 | None | 7 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 288 | 2 | 1 | 3 | 4.0 | N#Cc1c(NC(=O)C2CCCCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL396627 | 152016 | None | 7 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 288 | 2 | 1 | 3 | 4.0 | N#Cc1c(NC(=O)C2CCCCC2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 16644244 | 71247 | None | 5 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956436 | 71247 | None | 5 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57393990 | 71253 | None | 0 | Rat | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 335 | 3 | 2 | 3 | 4.2 | N#Cc1c(NC(=O)Cc2cc3ccccc3[nH]2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956442 | 71253 | None | 0 | Rat | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 335 | 3 | 2 | 3 | 4.2 | N#Cc1c(NC(=O)Cc2cc3ccccc3[nH]2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 57392239 | 71248 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 340 | 5 | 1 | 4 | 4.1 | COc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956437 | 71248 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 340 | 5 | 1 | 4 | 4.1 | COc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57390395 | 71228 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(-c3ccccc3)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956417 | 71228 | None | 0 | Rat | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 358 | 4 | 1 | 1 | 6.9 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(-c3ccccc3)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 15015051 | 71227 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 300 | 3 | 1 | 1 | 5.4 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(F)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956416 | 71227 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 300 | 3 | 1 | 1 | 5.4 | CC(C)c1cc(C(C)(C)C)cc(-c2ccc(F)cc2)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 57399213 | 71246 | None | 1 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956435 | 71246 | None | 1 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 | 10.1016/j.bmcl.2012.01.082 | |||
| 57395757 | 71238 | None | 0 | Rat | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 310 | 3 | 1 | 1 | 5.9 | Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1C | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956427 | 71238 | None | 0 | Rat | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 310 | 3 | 1 | 1 | 5.9 | Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1C | 10.1016/j.bmcl.2012.01.082 | |||
| 57400906 | 71226 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1ccccc1-c1cc(C(C)(C)C)cc(C(C)C)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956415 | 71226 | None | 0 | Rat | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 312 | 4 | 1 | 2 | 5.3 | COc1ccccc1-c1cc(C(C)(C)C)cc(C(C)C)c1CO | 10.1016/j.bmcl.2012.01.082 | |||
| 775619 | 71256 | None | 12 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 312 | 4 | 1 | 4 | 3.5 | N#Cc1c(NC(=O)COc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| CHEMBL1956445 | 71256 | None | 12 | Rat | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 312 | 4 | 1 | 4 | 3.5 | N#Cc1c(NC(=O)COc2ccccc2)sc2c1CCCC2 | 10.1016/j.bmcl.2012.01.082 | |||
| 2258 | 2991 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -15 | 4 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2278 | 328 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 4168 | 3 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16133238 | 2990 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2257 | 2990 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 44134520 | 2990 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 10 | 10.0 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 10 | 10.0 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 10 | 10.0 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 10 | 10.0 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 10 | 10.0 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2278 | 328 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | 4168 | 3 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2259 | 3346 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -190 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 129887154 | 583 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -177 | 3 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 155817438 | 583 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -177 | 3 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 16214732 | 583 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -177 | 3 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2269 | 583 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -177 | 3 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2281 | 583 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -177 | 3 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2272 | 3078 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -30 | 3 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 2258 | 2991 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -15 | 4 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16133238 | 2990 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2257 | 2990 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 44134520 | 2990 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16133238 | 2990 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 2257 | 2990 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 44134520 | 2990 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -44 | 6 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 3842 | 2436 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -2 | 5 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.5 | 8.5 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 2278 | 328 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 4168 | 3 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 1152 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 16129679 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 53395115 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 91898389 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1 | 8 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 2272 | 3078 | None | 0 | Human | Functional | pEC50 | > | 5.5 | 5.5 | -30 | 3 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2276 | 3345 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | -316 | 2 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 2259 | 3346 | None | 0 | Human | Functional | pEC50 | > | 6 | 6.0 | -190 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 43708 | 220189 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Drug Central | 525 | 10 | 3 | 13 | -0.7 | CN(C)CCN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)CC1=CSC(N)=N1)C2=O)C(O)=O | None | |||
| 131850923 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 155817437 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 16154651 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 2268 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 131850923 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 155817437 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16154651 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2268 | 3077 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 131850923 | 3077 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 155817437 | 3077 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 16154651 | 3077 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| 2268 | 3077 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 5 | Guide to Pharmacology | None | None | None | None | 16930633 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| CHEMBL524658 | 218104 | None | 0 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL524658 | 218104 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.bmc.2013.03.016 | |||||
| CHEMBL1893324 | 211519 | None | 20 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.bmc.2016.03.006 | |||||
| CHEMBL3884667 | 214877 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL1893324 | 211519 | None | 20 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.bmc.2013.03.016 | |||||
| CHEMBL1893324 | 211519 | None | 20 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2013.01.044 | |||||
| 72548703 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 161661 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 127034614 | 136590 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 3246 | 105 | 48 | 45 | -10.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| CHEMBL3736230 | 136590 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 3246 | 105 | 48 | 45 | -10.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| 127034614 | 136590 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 3246 | 105 | 48 | 45 | -10.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| CHEMBL3736230 | 136590 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 3246 | 105 | 48 | 45 | -10.8 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| 2263 | 257 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| 44566111 | 257 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| CHEMBL219499 | 257 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0609059 | |||||
| CHEMBL507480 | 216823 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||||
| CHEMBL4296687 | 216002 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O | 10.1021/jm701575k | |||||
| CHEMBL524852 | 218111 | None | 7 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||||
| 127035881 | 136572 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 3264 | 105 | 48 | 45 | -10.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| CHEMBL3736134 | 136572 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 3264 | 105 | 48 | 45 | -10.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| 127035881 | 136572 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 3264 | 105 | 48 | 45 | -10.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| CHEMBL3736134 | 136572 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 3264 | 105 | 48 | 45 | -10.6 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O | 10.1016/j.ejmech.2015.09.017 | |||
| CHEMBL1893324 | 211519 | None | 20 | Human | Binding | pKi | = | 10.2 | 10.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O | 10.1016/j.ejmech.2013.01.044 | |||||
| 1155 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 16129665 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3643 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| CHEMBL1201488 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| DB00021 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3842 | 2436 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 1152 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 16129679 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 53395115 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 91898389 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3293 | 468 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 1155 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 16129665 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3643 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| CHEMBL1201488 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| DB00021 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3293 | 468 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 3842 | 2436 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437714 | |||||
| 129887154 | 583 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 155817438 | 583 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 16214732 | 583 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2269 | 583 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2281 | 583 | None | 0 | Human | Binding | pIC50 | = | 5.1 | 5.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 11978642 | |||||
| 2275 | 3113 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 1155 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 16129665 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 3643 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| CHEMBL1201488 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| DB00021 | 3572 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 16132369 | 1918 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2280 | 1918 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 53230038 | 1918 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2273 | 3109 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2259 | 3346 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 1155 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 16129665 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 3643 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| CHEMBL1201488 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| DB00021 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 6.5 | 6.5 | - | 2 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2272 | 3078 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 11068102 | |||||
| 2259 | 3346 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9145428 | |||||
| 2266 | 2894 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 3842 | 2436 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 16133238 | 2990 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 2257 | 2990 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 44134520 | 2990 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 131850923 | 3077 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 155817437 | 3077 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 16154651 | 3077 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 2268 | 3077 | None | 0 | Rat | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8 | 8.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8 | 8.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8 | 8.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8 | 8.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8 | 8.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 16132369 | 1918 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2280 | 1918 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 53230038 | 1918 | None | 0 | Rat | Binding | pIC50 | = | 8.1 | 8.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2271 | 2895 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 16133238 | 2990 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2257 | 2990 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 44134520 | 2990 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2273 | 3109 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2275 | 3113 | None | 0 | Rat | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2271 | 2895 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 1152 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 16129679 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 53395115 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 91898389 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | Guide to Pharmacology | None | None | None | None | 9726637 | |||||
| 16133238 | 2990 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 2257 | 2990 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 44134520 | 2990 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 3 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 1152 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 16129679 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 53395115 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 91898389 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 9 | 9.0 | - | 4 | Guide to Pharmacology | None | None | None | None | 9928018 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pIC50 | = | 9.3 | 9.3 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 131850923 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 131850923 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 155817437 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 155817437 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 16154651 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 16154651 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 2268 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 10570056 | |||||
| 2268 | 3077 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Guide to Pharmacology | None | None | None | None | 9437716 | |||||
| 2259 | 3346 | None | 0 | Human | Binding | pIC50 | > | 6 | 6.0 | - | 0 | Guide to Pharmacology | None | None | None | None | 11931347 | |||||
| 16132300 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 16132300.0 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 53314964 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| CHEMBL1981592 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 9.7 | 9.7 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 16132300 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 16132300.0 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 53314964 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| CHEMBL1981592 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 16132300 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 16132300.0 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 53314964 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| CHEMBL1981592 | 218808 | 125I-VIP | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 1 | 3 | PDSP KiDatabase | 3325 | 113 | 51 | 48 | -14.6 | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N | None | |||
| 243 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762.0 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3502 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| CHEMBL117287 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| DB06480 | 3202 | 125I-VIP | 61 | Human | Binding | pKi | = | 5 | 5.0 | -1096 | 34 | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9.7 | 9.7 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 8.5 | 8.5 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 8.5 | 8.5 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 8.5 | 8.5 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 8.5 | 8.5 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 8.5 | 8.5 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 2274 | 3111 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 16132353 | 1789 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 2270 | 1789 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 16132369 | 1918 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 2280 | 1918 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 53230038 | 1918 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 2278 | 328 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | 316 | 2 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 2258 | 2991 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 3 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 16133238 | 2990 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 2257 | 2990 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 44134520 | 2990 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 3 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 10801840 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9 | 9.0 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9454823 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9454823 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9454823 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9454823 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 9454823 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8390245 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8390245 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8390245 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8390245 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9.1 | 9.1 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8390245 | |||||
| 1152 | 3995 | None | 15 | Human | Binding | pKi | = | 9.8 | 9.8 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 16129679 | 3995 | None | 15 | Human | Binding | pKi | = | 9.8 | 9.8 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 53395115 | 3995 | None | 15 | Human | Binding | pKi | = | 9.8 | 9.8 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 91898389 | 3995 | None | 15 | Human | Binding | pKi | = | 9.8 | 9.8 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Binding | pKi | = | 9.8 | 9.8 | 5 | 4 | Guide to Pharmacology | None | None | None | None | 8074647 | |||||
| 2276 | 3345 | None | 0 | Human | Binding | pKi | > | 5.5 | 5.5 | -316 | 2 | Guide to Pharmacology | None | None | None | None | 9152366 | |||||
| 1155 | 3572 | None | 0 | Human | Binding | pKi | > | 5 | 5.0 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 16129665 | 3572 | None | 0 | Human | Binding | pKi | > | 5 | 5.0 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| 3643 | 3572 | None | 0 | Human | Binding | pKi | > | 5 | 5.0 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| CHEMBL1201488 | 3572 | None | 0 | Human | Binding | pKi | > | 5 | 5.0 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||
| DB00021 | 3572 | None | 0 | Human | Binding | pKi | > | 5 | 5.0 | -3162 | 2 | Guide to Pharmacology | None | None | None | None | 8791009 | |||||