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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	68344426	175800	None	0	Human	Functional	pEC50	=	4.5	4.5	-4	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assay	ChEMBL	250	0	1	3	2.6	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1	nan
	CHEMBL4582048	175800	None	0	Human	Functional	pEC50	=	4.5	4.5	-4	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assay	ChEMBL	250	0	1	3	2.6	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1	nan
	23259348	170016	None	0	Human	Functional	pEC50	=	4.5	4.5	-3	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	250	0	1	3	2.6	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1	nan
	CHEMBL4440983	170016	None	0	Human	Functional	pEC50	=	4.5	4.5	-3	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	250	0	1	3	2.6	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1	nan
	1499	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	536	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	12460	253	None	0	Human	Functional	pEC50	=	2.6	2.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	163	0	1	4	-0.7	CC1=CC(=O)NS(=O)(=O)O1	15537898
	36573	253	None	0	Human	Functional	pEC50	=	2.6	2.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	163	0	1	4	-0.7	CC1=CC(=O)NS(=O)(=O)O1	15537898
	CHEMBL176687	253	None	0	Human	Functional	pEC50	=	2.6	2.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	163	0	1	4	-0.7	CC1=CC(=O)NS(=O)(=O)O1	15537898
	5143	3457	None	0	Human	Functional	pEC50	=	3.0	3.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	183	0	1	3	0.1	O=C1NS(=O)(=O)c2c1cccc2	15537898
	5432	3457	None	0	Human	Functional	pEC50	=	3.0	3.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	183	0	1	3	0.1	O=C1NS(=O)(=O)c2c1cccc2	15537898
	CHEMBL310671	3457	None	0	Human	Functional	pEC50	=	3.0	3.0	1	2	UnclassifiedUnclassified	Guide to Pharmacology	183	0	1	3	0.1	O=C1NS(=O)(=O)c2c1cccc2	15537898
	12438	471	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	UnclassifiedUnclassified	Guide to Pharmacology	341	3	1	6	3.3	COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O	15537898
	2236	471	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	UnclassifiedUnclassified	Guide to Pharmacology	341	3	1	6	3.3	COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O	15537898
	CHEMBL93353	471	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	UnclassifiedUnclassified	Guide to Pharmacology	341	3	1	6	3.3	COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O	15537898
	12470	1276	None	0	Human	Functional	pIC50	=	1.8	1.8	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	179	2	2	2	0.7	C1CCC(CC1)NS(=O)(=O)O	28919036
	7533	1276	None	0	Human	Functional	pIC50	=	1.8	1.8	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	179	2	2	2	0.7	C1CCC(CC1)NS(=O)(=O)O	28919036
	CHEMBL1206440	1276	None	0	Human	Functional	pIC50	=	1.8	1.8	-3	2	UnclassifiedUnclassified	Guide to Pharmacology	179	2	2	2	0.7	C1CCC(CC1)NS(=O)(=O)O	28919036
	412	3460	None	34	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	22059530
	73571	3460	None	34	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	22059530
	CHEMBL448297	3460	None	34	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	22059530
	DB08517	3460	None	34	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	22059530
	25099817	1802	None	0	Human	Functional	pIC50	=	5.5	5.5	1	3	UnclassifiedUnclassified	Guide to Pharmacology	198	4	1	1	3.3	CC1CCC(C1(C)C)CCCC(=O)O	20537538
	9112	1802	None	0	Human	Functional	pIC50	=	5.5	5.5	1	3	UnclassifiedUnclassified	Guide to Pharmacology	198	4	1	1	3.3	CC1CCC(C1(C)C)CCCC(=O)O	20537538

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	5379096	186513	None	55	Human	Binding	pIC50	=	5.0	5.0	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	330	3	3	7	2.6	COc1cc(-c2cc(=O)c3c(O)c(OC)c(O)cc3o2)ccc1O	10.1021/np200391c
	CHEMBL487601	186513	None	55	Human	Binding	pIC50	=	5.0	5.0	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	330	3	3	7	2.6	COc1cc(-c2cc(=O)c3c(O)c(OC)c(O)cc3o2)ccc1O	10.1021/np200391c
	44576022	187048	None	1	Human	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	372	4	2	7	3.4	COc1cc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)ccc1OC(=O)C(C)C	10.1021/np200391c
	CHEMBL490162	187048	None	1	Human	Binding	pIC50	=	5.7	5.7	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	372	4	2	7	3.4	COc1cc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)ccc1OC(=O)C(C)C	10.1021/np200391c
	44412004	78290	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	316	3	2	6	2.8	COc1cc2c(c(O)c1OC)C(=O)C[C@@H](c1ccc(O)cc1)O2	10.1021/np200391c
	CHEMBL210692	78290	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	316	3	2	6	2.8	COc1cc2c(c(O)c1OC)C(=O)C[C@@H](c1ccc(O)cc1)O2	10.1021/np200391c
	412	3460	None	34	Human	Binding	pIC50	=	5.4	5.4	-	3	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	10.1021/np200391c
	73571	3460	None	34	Human	Binding	pIC50	=	5.4	5.4	-	3	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	10.1021/np200391c
	CHEMBL448297	3460	None	34	Human	Binding	pIC50	=	5.4	5.4	-	3	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	10.1021/np200391c
	DB08517	3460	None	34	Human	Binding	pIC50	=	5.4	5.4	-	3	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunitInhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	286	2	2	5	2.8	COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O	10.1021/np200391c
	13858192	113372	None	15	Human	Binding	pIC50	=	5.1	5.1	-	0	Antagonist activity at human TAS2R31 expressed in HEK-293T cells stably expressing Galpha16gust44 assessed as inhibition receptor response to saccharin by fluorescence assayAntagonist activity at human TAS2R31 expressed in HEK-293T cells stably expressing Galpha16gust44 assessed as inhibition receptor response to saccharin by fluorescence assay	ChEMBL	362	5	1	3	5.1	C=C1CC[C@H]2C(C)(C)[C@@H](OC(C)=O)CC[C@]2(C)[C@H]1CC/C(C)=C/C(=O)O	10.1021/np5001413
	CHEMBL3315351	113372	None	15	Human	Binding	pIC50	=	5.1	5.1	-	0	Antagonist activity at human TAS2R31 expressed in HEK-293T cells stably expressing Galpha16gust44 assessed as inhibition receptor response to saccharin by fluorescence assayAntagonist activity at human TAS2R31 expressed in HEK-293T cells stably expressing Galpha16gust44 assessed as inhibition receptor response to saccharin by fluorescence assay	ChEMBL	362	5	1	3	5.1	C=C1CC[C@H]2C(C)(C)[C@@H](OC(C)=O)CC[C@]2(C)[C@H]1CC/C(C)=C/C(=O)O	10.1021/np5001413

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Main reference

Ligand source activities (1 row/activity)