MCH1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WWL

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41421-024-00754-0

PUBLICATION DATE

Nov. 13, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

86 interactions (Click to see)

LIGANDS

Melanin-concentrating hormone - Agonist

PHYSIOLOGICAL LIGANDS

melanin-concentrating hormone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 319 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 217 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 217 - G.H5 I 343 G.H5.15
Polar ICL1 W 142 - G.HN R 24 G.HN.48
Hydrophobic ICL1 W 142 - G.HN R 24 G.HN.48
Van-der-waals ICL1 W 142 - G.HN R 24 G.HN.48
Hydrophobic ICL1 N 144 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 N 144 - G.hns1 A 31 G.hns1.02
Polar TM6 T 326 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 326 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 326 6x36 G.H5 L 353 G.H5.25
Polar TM6 Q 313 6x23 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 Q 313 6x23 G.h4s6 K 317 G.h4s6.11
Polar ICL2 T 221 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 221 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 221 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 Y 380 7x53 G.H5 G 352 G.H5.24
Polar ICL1 C 143 - G.HN R 24 G.HN.48
Hydrophobic ICL1 C 143 - G.HN R 24 G.HN.48
Polar TM3 A 213 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 213 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 213 3x53 G.H5 N 347 G.H5.19
Polar TM6 Q 313 6x23 G.S6 I 319 G.S6.01
Van-der-waals TM6 Q 313 6x23 G.S6 I 319 G.S6.01
Hydrophobic TM4 P 226 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 P 226 4x39 G.HN E 28 G.HN.52
Polar TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 210 3x50 G.H5 L 353 G.H5.25
Ionic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 319 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 319 6x29 G.H5 D 341 G.H5.13
Hydrophobic ICL1 L 140 - G.HN L 23 G.HN.47
Van-der-waals ICL1 L 140 - G.HN L 23 G.HN.47
Hydrophobic ICL3 M 304 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 304 - G.H5 I 344 G.H5.16
Hydrophobic TM6 R 319 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 319 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM7 Y 380 7x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 318 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL1 C 143 - G.HN G 27 G.HN.51
Hydrophobic ICL3 V 308 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 V 308 - G.H5 D 337 G.H5.09
Hydrophobic TM5 I 300 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 322 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 322 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL1 C 143 - G.HN E 28 G.HN.52
Van-der-waals ICL1 C 143 - G.HN E 28 G.HN.52
Hydrophobic ICL3 V 308 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 A 213 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 323 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 Y 297 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 297 5x58 G.H5 L 353 G.H5.25
Ionic ICL2 K 222 - G.s2s3 D 193 G.s2s3.02
Polar ICL1 N 144 - G.HN E 28 G.HN.52
Hydrophobic TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Polar ICL3 S 306 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 217 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 V 308 - G.H5 A 338 G.H5.10
Hydrophobic ICL2 I 218 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 I 218 - G.H5 I 343 G.H5.15
Hydrophobic TM2 P 147 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 P 147 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 V 308 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 308 - G.H5 F 334 G.H5.06
Polar TM3 R 210 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 210 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 210 3x50 G.H5 C 351 G.H5.23
Polar H8 E 385 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 218 - G.S3 L 194 G.S3.01
Van-der-waals TM3 T 214 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 P 147 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL1 L 140 - G.HN D 20 G.HN.44
Polar ICL1 H 141 - G.HN R 24 G.HN.48
Hydrophobic ICL1 H 141 - G.HN R 24 G.HN.48
Van-der-waals ICL1 H 141 - G.HN R 24 G.HN.48
Hydrophobic TM6 I 330 6x40 G.H5 L 353 G.H5.25
Van-der-waals ICL1 W 142 - G.HN E 28 G.HN.52
Hydrophobic H8 C 384 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 C 384 8x47 G.H5 G 352 G.H5.24
Polar ICL3 S 306 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 306 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 306 - G.H5 D 341 G.H5.13
Van-der-waals TM6 Q 313 6x23 G.h4s6 N 311 G.h4s6.02
Hydrophobic ICL3 P 310 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 217 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 217 - G.H5 I 344 G.H5.16
Hydrophobic TM6 R 319 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 323 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 309 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 A 309 - G.H5 D 341 G.H5.13
Polar TM7 Y 380 7x53 G.H5 D 350 G.H5.22
Polar TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 M 304 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 A 309 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 A 309 - G.S6 Y 320 G.S6.02
Polar TM6 S 315 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 S 315 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 S 315 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 T 214 3x54 G.H5 I 344 G.H5.16
Ionic TM6 R 319 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 319 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL1 L 140 - G.HN R 24 G.HN.48
Van-der-waals ICL1 L 140 - G.HN R 24 G.HN.48
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