Refined structure (9IY8) of G13 - GPR55

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2025-03-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (57.3%), 161 from model (42.7%)
Residue sidechains - 198 from structure (52.5%), 179 from model (47.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 A G.HN.02 AF2 AF2
G.HN 3 D G.HN.03 AF2 AF2
G.HN 4 F G.HN.04 AF2 AF2
G.HN 5 L G.HN.05 AF2 AF2
G.HN 6 P G.HN.06 AF2 AF2
G.HN 7 S G.HN.09 AF2 AF2
G.HN 8 R G.HN.10 AF2 AF2
G.HN 9 S G.HN.11 AF2 AF2
G.HN 10 V G.HN.12 AF2 AF2
G.HN 11 L G.HN.13 AF2 AF2
G.HN 12 S G.HN.14 AF2 AF2
G.HN 13 V G.HN.15 AF2 AF2
G.HN 14 C G.HN.16 AF2 AF2
G.HN 15 F G.HN.17 AF2 AF2
G.HN 16 P G.HN.18 AF2 AF2
G.HN 17 G G.HN.19 AF2 AF2
G.HN 18 C G.HN.20 AF2 AF2
G.HN 19 L G.HN.21 Structure AF2
G.HN 20 L G.HN.22 Structure Structure
G.HN 21 T G.HN.23 Structure AF2
G.HN 22 S G.HN.24 Structure AF2
G.HN 23 G G.HN.25 Structure AF2
G.HN 24 E G.HN.33 Structure AF2
G.HN 25 A G.HN.34 Structure AF2
G.HN 26 E G.HN.35 Structure AF2
G.HN 27 Q G.HN.36 Structure AF2
G.HN 28 Q G.HN.37 Structure AF2
G.HN 29 R G.HN.38 Structure AF2
G.HN 30 K G.HN.39 Structure AF2
G.HN 31 S G.HN.40 Structure Structure
G.HN 32 K G.HN.41 Structure Structure
G.HN 33 E G.HN.42 Structure Structure
G.HN 34 I G.HN.43 Structure Structure
G.HN 35 D G.HN.44 Structure Structure
G.HN 36 K G.HN.45 Structure Structure
G.HN 37 C G.HN.46 Structure Structure
G.HN 38 L G.HN.47 Structure Structure
G.HN 39 S G.HN.48 Structure Structure
G.HN 40 R G.HN.49 Structure Structure
G.HN 41 E G.HN.50 Structure Structure
G.HN 42 K G.HN.51 Structure Structure
G.HN 43 T G.HN.52 Structure Structure
G.HN 44 Y G.HN.53 Structure Structure
G.hns1 45 V G.hns1.01 Structure Structure
G.hns1 46 K G.hns1.02 Structure Structure
G.hns1 47 R G.hns1.03 Structure Structure
G.S1 48 L G.S1.01 Structure Structure
G.S1 49 V G.S1.02 Structure Structure
G.S1 50 K G.S1.03 Structure Structure
G.S1 51 I G.S1.04 Structure Structure
G.S1 52 L G.S1.05 Structure Structure
G.S1 53 L G.S1.06 Structure Structure
G.S1 54 L G.S1.07 Structure Structure
G.s1h1 55 G G.s1h1.01 Structure Structure
G.s1h1 56 A G.s1h1.02 Structure Structure
G.s1h1 57 G G.s1h1.03 Structure AF2
G.s1h1 58 E G.s1h1.04 Structure AF2
G.s1h1 59 S G.s1h1.05 Structure Structure
G.s1h1 60 G G.s1h1.06 Structure Structure
G.H1 61 K G.H1.01 Structure Structure
G.H1 62 S G.H1.02 Structure Structure
G.H1 63 T G.H1.03 Structure Structure
G.H1 64 F G.H1.04 Structure Structure
G.H1 65 L G.H1.05 Structure Structure
G.H1 66 K G.H1.06 Structure Structure
G.H1 67 Q G.H1.07 Structure Structure
G.H1 68 M G.H1.08 Structure Structure
G.H1 69 R G.H1.09 Structure Structure
G.H1 70 I G.H1.10 Structure Structure
G.H1 71 I G.H1.11 Structure Structure
G.H1 72 H G.H1.12 AF2 AF2
G.h1ha 73 G G.h1ha.01 AF2 AF2
G.h1ha 74 Q G.h1ha.02 AF2 AF2
G.h1ha 75 D G.h1ha.03 AF2 AF2
G.h1ha 76 F G.h1ha.04 AF2 AF2
G.h1ha 77 D G.h1ha.05 AF2 AF2
H.HA 78 Q H.HA.01 AF2 AF2
H.HA 79 R H.HA.02 AF2 AF2
H.HA 80 A H.HA.03 AF2 AF2
H.HA 81 R H.HA.04 AF2 AF2
H.HA 82 E H.HA.05 AF2 AF2
H.HA 83 E H.HA.06 AF2 AF2
H.HA 84 F H.HA.07 AF2 AF2
H.HA 85 R H.HA.08 AF2 AF2
H.HA 86 P H.HA.09 AF2 AF2
H.HA 87 T H.HA.10 AF2 AF2
H.HA 88 I H.HA.11 AF2 AF2
H.HA 89 Y H.HA.12 AF2 AF2
H.HA 90 S H.HA.13 AF2 AF2
H.HA 91 N H.HA.14 AF2 AF2
H.HA 92 V H.HA.15 AF2 AF2
H.HA 93 I H.HA.16 AF2 AF2
H.HA 94 K H.HA.17 AF2 AF2
H.HA 95 G H.HA.18 AF2 AF2
H.HA 96 M H.HA.19 AF2 AF2
H.HA 97 R H.HA.20 AF2 AF2
H.HA 98 V H.HA.21 AF2 AF2
H.HA 99 L H.HA.22 AF2 AF2
H.HA 100 V H.HA.23 AF2 AF2
H.HA 101 D H.HA.24 AF2 AF2
H.HA 102 A H.HA.25 AF2 AF2
H.HA 103 R H.HA.26 AF2 AF2
H.HA 104 E H.HA.27 AF2 AF2
H.HA 105 K H.HA.28 AF2 AF2
H.HA 106 L H.HA.29 AF2 AF2
H.hahb 107 H H.hahb.01 AF2 AF2
H.hahb 108 I H.hahb.04 AF2 AF2
H.hahb 109 P H.hahb.05 AF2 AF2
H.hahb 110 W H.hahb.06 AF2 AF2
H.hahb 111 G H.hahb.07 AF2 AF2
H.hahb 112 D H.hahb.08 AF2 AF2
H.hahb 113 N H.hahb.09 AF2 AF2
H.HB 114 S H.HB.01 AF2 AF2
H.HB 115 N H.HB.02 AF2 AF2
H.HB 116 Q H.HB.03 AF2 AF2
H.HB 117 Q H.HB.04 AF2 AF2
H.HB 118 H H.HB.05 AF2 AF2
H.HB 119 G H.HB.06 AF2 AF2
H.HB 120 D H.HB.07 AF2 AF2
H.HB 121 K H.HB.08 AF2 AF2
H.HB 122 M H.HB.09 AF2 AF2
H.HB 123 M H.HB.10 AF2 AF2
H.HB 124 S H.HB.11 AF2 AF2
H.HB 125 F H.HB.12 AF2 AF2
H.HB 126 D H.HB.13 AF2 AF2
H.HB 127 T H.HB.14 AF2 AF2
H.hbhc 128 R H.hbhc.01 AF2 AF2
H.hbhc 129 A H.hbhc.02 AF2 AF2
H.hbhc 130 P H.hbhc.03 AF2 AF2
H.hbhc 131 M H.hbhc.04 AF2 AF2
H.hbhc 132 A H.hbhc.05 AF2 AF2
H.hbhc 133 A H.hbhc.06 AF2 AF2
H.hbhc 134 Q H.hbhc.07 AF2 AF2
H.hbhc 135 G H.hbhc.08 AF2 AF2
H.hbhc 136 M H.hbhc.09 AF2 AF2
H.hbhc 137 V H.hbhc.10 AF2 AF2
H.hbhc 138 E H.hbhc.11 AF2 AF2
H.hbhc 139 T H.hbhc.12 AF2 AF2
H.hbhc 140 R H.hbhc.13 AF2 AF2
H.hbhc 141 V H.hbhc.14 AF2 AF2
H.hbhc 142 F H.hbhc.15 AF2 AF2
H.HC 143 L H.HC.01 AF2 AF2
H.HC 144 Q H.HC.02 AF2 AF2
H.HC 145 Y H.HC.03 AF2 AF2
H.HC 146 L H.HC.04 AF2 AF2
H.HC 147 P H.HC.05 AF2 AF2
H.HC 148 A H.HC.06 AF2 AF2
H.HC 149 I H.HC.07 AF2 AF2
H.HC 150 R H.HC.08 AF2 AF2
H.HC 151 A H.HC.09 AF2 AF2
H.HC 152 L H.HC.10 AF2 AF2
H.HC 153 W H.HC.11 AF2 AF2
H.HC 154 A H.HC.12 AF2 AF2
H.hchd 155 D H.hchd.01 AF2 AF2
H.HD 156 S H.HD.01 AF2 AF2
H.HD 157 G H.HD.02 AF2 AF2
H.HD 158 I H.HD.03 AF2 AF2
H.HD 159 Q H.HD.04 AF2 AF2
H.HD 160 N H.HD.05 AF2 AF2
H.HD 161 A H.HD.06 AF2 AF2
H.HD 162 Y H.HD.07 AF2 AF2
H.HD 163 D H.HD.08 AF2 AF2
H.HD 164 R H.HD.09 AF2 AF2
H.HD 165 R H.HD.10 AF2 AF2
H.HD 166 R H.HD.11 AF2 AF2
H.HD 167 E H.HD.12 AF2 AF2
H.hdhe 168 F H.hdhe.01 AF2 AF2
H.hdhe 169 Q H.hdhe.02 AF2 AF2
H.hdhe 170 L H.hdhe.03 AF2 AF2
H.hdhe 171 G H.hdhe.04 AF2 AF2
H.hdhe 172 E H.hdhe.05 AF2 AF2
H.HE 173 S H.HE.01 AF2 AF2
H.HE 174 V H.HE.02 AF2 AF2
H.HE 175 K H.HE.03 AF2 AF2
H.HE 176 Y H.HE.04 AF2 AF2
H.HE 177 F H.HE.05 AF2 AF2
H.HE 178 L H.HE.06 AF2 AF2
H.HE 179 D H.HE.07 AF2 AF2
H.HE 180 N H.HE.08 AF2 AF2
H.HE 181 L H.HE.09 AF2 AF2
H.HE 182 D H.HE.10 AF2 AF2
H.HE 183 K H.HE.11 AF2 AF2
H.HE 184 L H.HE.12 AF2 AF2
H.HE 185 G H.HE.13 AF2 AF2
H.hehf 186 E H.hehf.01 AF2 AF2
H.hehf 187 P H.hehf.02 AF2 AF2
H.hehf 188 D H.hehf.03 AF2 AF2
H.hehf 189 Y H.hehf.04 AF2 AF2
H.hehf 190 I H.hehf.05 AF2 AF2
H.hehf 191 P H.hehf.06 AF2 AF2
H.hehf 192 S H.hehf.07 AF2 AF2
H.HF 193 Q H.HF.01 AF2 AF2
H.HF 194 Q H.HF.02 AF2 AF2
H.HF 195 D H.HF.03 AF2 AF2
H.HF 196 I H.HF.04 AF2 AF2
H.HF 197 L H.HF.05 AF2 AF2
H.HF 198 L H.HF.06 AF2 AF2
G.hfs2 199 A G.hfs2.01 AF2 AF2
G.hfs2 200 R G.hfs2.02 AF2 AF2
G.hfs2 201 R G.hfs2.03 AF2 AF2
G.hfs2 202 P G.hfs2.04 AF2 AF2
G.hfs2 203 T G.hfs2.05 AF2 AF2
G.hfs2 204 K G.hfs2.06 AF2 AF2
G.hfs2 205 G G.hfs2.07 Structure Structure
G.S2 206 I G.S2.01 Structure Structure
G.S2 207 H G.S2.02 Structure Structure
G.S2 208 E G.S2.03 Structure Structure
G.S2 209 Y G.S2.04 Structure Structure
G.S2 210 D G.S2.05 Structure Structure
G.S2 211 F G.S2.06 Structure Structure
G.S2 212 E G.S2.07 Structure Structure
G.S2 213 I G.S2.08 Structure Structure
G.s2s3 214 K G.s2s3.01 Structure Structure
G.s2s3 215 N G.s2s3.02 Structure Structure
G.S3 216 V G.S3.01 Structure Structure
G.S3 217 P G.S3.02 Structure Structure
G.S3 218 F G.S3.03 Structure Structure
G.S3 219 K G.S3.04 Structure Structure
G.S3 220 M G.S3.05 Structure Structure
G.S3 221 V G.S3.06 Structure Structure
G.S3 222 D G.S3.07 Structure Structure
G.S3 223 V G.S3.08 Structure Structure
G.s3h2 224 G G.s3h2.01 Structure Structure
G.s3h2 225 G G.s3h2.02 Structure Structure
G.s3h2 226 Q G.s3h2.03 Structure Structure
G.H2 227 R G.H2.01 Structure Structure
G.H2 228 S G.H2.02 Structure Structure
G.H2 229 E G.H2.03 Structure Structure
G.H2 230 R G.H2.04 Structure Structure
G.H2 231 K G.H2.05 Structure Structure
G.H2 232 R G.H2.06 Structure Structure
G.H2 233 W G.H2.07 Structure Structure
G.H2 234 F G.H2.08 Structure Structure
G.H2 235 E G.H2.09 Structure Structure
G.H2 236 C G.H2.10 Structure Structure
G.h2s4 237 F G.h2s4.01 Structure Structure
G.h2s4 238 D G.h2s4.02 Structure Structure
G.h2s4 239 S G.h2s4.03 Structure Structure
G.h2s4 240 V G.h2s4.04 Structure Structure
G.h2s4 241 T G.h2s4.05 Structure Structure
G.S4 242 S G.S4.01 Structure Structure
G.S4 243 I G.S4.02 Structure Structure
G.S4 244 L G.S4.03 Structure Structure
G.S4 245 F G.S4.04 Structure Structure
G.S4 246 L G.S4.05 Structure Structure
G.S4 247 V G.S4.06 Structure Structure
G.S4 248 S G.S4.07 Structure AF2
G.s4h3 249 S G.s4h3.01 Structure Structure
G.s4h3 250 S G.s4h3.02 Structure Structure
G.s4h3 251 E G.s4h3.03 Structure AF2
G.s4h3 252 F G.s4h3.04 Structure Structure
G.s4h3 253 D G.s4h3.05 AF2 AF2
G.s4h3 254 Q G.s4h3.06 AF2 AF2
G.s4h3 255 V G.s4h3.07 AF2 AF2
G.s4h3 256 L G.s4h3.08 AF2 AF2
G.s4h3 257 M G.s4h3.09 AF2 AF2
G.s4h3 258 E G.s4h3.10 AF2 AF2
G.s4h3 259 D G.s4h3.11 AF2 AF2
G.s4h3 260 R G.s4h3.12 AF2 AF2
G.s4h3 261 L G.s4h3.13 AF2 AF2
G.s4h3 262 T G.s4h3.14 AF2 AF2
G.s4h3 263 N G.s4h3.15 Structure Structure
G.H3 264 R G.H3.01 Structure Structure
G.H3 265 L G.H3.02 Structure Structure
G.H3 266 T G.H3.03 Structure Structure
G.H3 267 E G.H3.04 Structure Structure
G.H3 268 S G.H3.05 Structure Structure
G.H3 269 L G.H3.06 Structure Structure
G.H3 270 N G.H3.07 Structure Structure
G.H3 271 I G.H3.08 Structure AF2
G.H3 272 F G.H3.09 Structure Structure
G.H3 273 E G.H3.10 Structure Structure
G.H3 274 T G.H3.11 Structure Structure
G.H3 275 I G.H3.12 Structure Structure
G.H3 276 V G.H3.13 Structure Structure
G.H3 277 N G.H3.14 Structure Structure
G.H3 278 N G.H3.15 Structure Structure
G.H3 279 R G.H3.16 Structure Structure
G.H3 280 V G.H3.17 Structure Structure
G.H3 281 F G.H3.18 Structure Structure
G.h3s5 282 S G.h3s5.01 Structure Structure
G.h3s5 283 N G.h3s5.02 Structure Structure
G.h3s5 284 V G.h3s5.03 Structure Structure
G.S5 285 S G.S5.01 Structure Structure
G.S5 286 I G.S5.02 Structure Structure
G.S5 287 I G.S5.03 Structure Structure
G.S5 288 L G.S5.04 Structure Structure
G.S5 289 F G.S5.05 Structure Structure
G.S5 290 L G.S5.06 Structure Structure
G.S5 291 N G.S5.07 Structure Structure
G.s5hg 292 K G.s5hg.01 Structure Structure
G.HG 293 T G.HG.01 Structure Structure
G.HG 294 D G.HG.02 Structure Structure
G.HG 295 L G.HG.03 Structure Structure
G.HG 296 L G.HG.04 Structure Structure
G.HG 297 E G.HG.05 Structure Structure
G.HG 298 E G.HG.06 Structure Structure
G.HG 299 K G.HG.07 Structure Structure
G.HG 300 V G.HG.08 Structure Structure
G.HG 301 Q G.HG.09 Structure Structure
G.HG 302 I G.HG.12 Structure Structure
G.HG 303 V G.HG.13 Structure Structure
G.HG 304 S G.HG.14 Structure Structure
G.HG 305 I G.HG.15 Structure Structure
G.HG 306 K G.HG.16 Structure Structure
G.HG 307 D G.HG.17 Structure Structure
G.hgh4 308 Y G.hgh4.01 Structure Structure
G.hgh4 309 F G.hgh4.02 Structure Structure
G.hgh4 310 L G.hgh4.03 Structure Structure
G.hgh4 311 E G.hgh4.04 Structure Structure
G.hgh4 312 F G.hgh4.05 Structure Structure
G.hgh4 313 E G.hgh4.06 Structure Structure
G.hgh4 314 G G.hgh4.07 Structure Structure
G.hgh4 315 D G.hgh4.08 Structure Structure
G.H4 316 P G.H4.01 Structure Structure
G.H4 317 H G.H4.02 Structure Structure
G.H4 318 C G.H4.03 Structure Structure
G.H4 319 L G.H4.04 Structure Structure
G.H4 320 R G.H4.05 Structure Structure
G.H4 321 D G.H4.06 Structure Structure
G.H4 322 V G.H4.07 Structure Structure
G.H4 323 Q G.H4.08 Structure Structure
G.H4 324 K G.H4.09 Structure Structure
G.H4 325 F G.H4.10 Structure Structure
G.H4 326 L G.H4.11 Structure Structure
G.H4 327 V G.H4.12 Structure Structure
G.H4 328 E G.H4.13 Structure Structure
G.H4 329 C G.H4.14 Structure Structure
G.H4 330 F G.H4.15 Structure Structure
G.H4 331 R G.H4.16 Structure Structure
G.H4 332 N G.H4.17 Structure Structure
G.h4s6 333 K G.h4s6.01 Structure Structure
G.h4s6 334 R G.h4s6.08 Structure Structure
G.h4s6 335 R G.h4s6.09 Structure Structure
G.h4s6 336 D G.h4s6.10 Structure Structure
G.h4s6 337 Q G.h4s6.11 Structure Structure
G.h4s6 338 Q G.h4s6.12 Structure Structure
G.h4s6 339 Q G.h4s6.13 Structure Structure
G.h4s6 340 K G.h4s6.19 Structure Structure
G.h4s6 341 P G.h4s6.20 Structure Structure
G.S6 342 L G.S6.01 Structure Structure
G.S6 343 Y G.S6.02 Structure Structure
G.S6 344 H G.S6.03 Structure Structure
G.S6 345 H G.S6.04 Structure Structure
G.S6 346 F G.S6.05 Structure Structure
G.s6h5 347 T G.s6h5.01 Structure Structure
G.s6h5 348 T G.s6h5.02 Structure Structure
G.s6h5 349 A G.s6h5.03 Structure Structure
G.s6h5 350 I G.s6h5.04 Structure Structure
G.s6h5 351 N G.s6h5.05 Structure Structure
G.H5 352 T G.H5.01 Structure Structure
G.H5 353 E G.H5.02 Structure Structure
G.H5 354 N G.H5.03 Structure Structure
G.H5 355 I G.H5.04 Structure AF2
G.H5 356 R G.H5.05 Structure Structure
G.H5 357 L G.H5.06 Structure Structure
G.H5 358 V G.H5.07 Structure AF2
G.H5 359 F G.H5.08 Structure Structure
G.H5 360 R G.H5.09 Structure Structure
G.H5 361 D G.H5.10 Structure Structure
G.H5 362 V G.H5.11 Structure Structure
G.H5 363 K G.H5.12 Structure Structure
G.H5 364 D G.H5.13 Structure Structure
G.H5 365 T G.H5.14 Structure Structure
G.H5 366 I G.H5.15 Structure Structure
G.H5 367 L G.H5.16 Structure Structure
G.H5 368 H G.H5.17 Structure Structure
G.H5 369 D G.H5.18 Structure Structure
G.H5 370 N G.H5.19 Structure Structure
G.H5 371 L G.H5.20 Structure Structure
G.H5 372 K G.H5.21 Structure Structure
G.H5 373 Q G.H5.22 Structure Structure
G.H5 374 L G.H5.23 Structure Structure
G.H5 375 M G.H5.24 Structure Structure
G.H5 376 L G.H5.25 Structure Structure
G.H5 377 Q G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 291 from structure (92.1%), 25 from model (7.9%)
Residue sidechains - 290 from structure (91.8%), 26 from model (8.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 C - AF2 AF2
N-term 11 L - AF2 AF2
TM1 12 F 1.24x24 Structure Structure
TM1 13 D 1.25x25 Structure Structure
TM1 14 G 1.26x26 Structure Structure
TM1 15 V 1.27x27 Structure Structure
TM1 16 N 1.28x28 Structure Structure
TM1 17 E 1.29x29 Structure Structure
TM1 18 L 1.30x30 Structure Structure
TM1 19 M 1.31x31 Structure Structure
TM1 20 K 1.32x32 Structure Structure
TM1 21 T 1.33x33 Structure Structure
TM1 22 L 1.34x34 Structure Structure
TM1 23 Q 1.35x35 Structure Structure
TM1 24 F 1.36x36 Structure Structure
TM1 25 A 1.37x37 Structure Structure
TM1 26 V 1.38x38 Structure Structure
TM1 27 H 1.39x39 Structure Structure
TM1 28 I 1.40x40 Structure Structure
TM1 29 P 1.41x41 Structure Structure
TM1 30 T 1.42x42 Structure Structure
TM1 31 F 1.43x43 Structure Structure
TM1 32 V 1.44x44 Structure Structure
TM1 33 L 1.45x45 Structure Structure
TM1 34 G 1.46x46 Structure Structure
TM1 35 L 1.47x47 Structure Structure
TM1 36 L 1.48x48 Structure Structure
TM1 37 L 1.49x49 Structure Structure
TM1 38 N 1.50x50 Structure Structure
TM1 39 L 1.51x51 Structure Structure
TM1 40 L 1.52x52 Structure Structure
TM1 41 A 1.53x53 Structure Structure
TM1 42 I 1.54x54 Structure Structure
TM1 43 H 1.55x55 Structure Structure
TM1 44 G 1.56x56 Structure Structure
TM1 45 F 1.57x57 Structure Structure
TM1 46 S 1.58x58 Structure Structure
TM1 47 T 1.59x59 Structure Structure
TM1 48 F 1.60x60 Structure Structure
TM1 49 L 1.61x61 Structure Structure
TM1 50 K 1.62x62 Structure Structure
TM1 51 N 1.63x63 Structure Structure
TM1 52 R 1.64x64 Structure Structure
ICL1 53 W - Structure Structure
ICL1 54 P - Structure Structure
ICL1 55 D - Structure Structure
ICL1 56 Y - Structure Structure
TM2 57 A 2.37x37 Structure Structure
TM2 58 A 2.38x38 Structure Structure
TM2 59 T 2.39x39 Structure Structure
TM2 60 S 2.40x40 Structure Structure
TM2 61 I 2.41x41 Structure Structure
TM2 62 Y 2.42x42 Structure Structure
TM2 63 M 2.43x43 Structure Structure
TM2 64 I 2.44x44 Structure Structure
TM2 65 N 2.45x45 Structure Structure
TM2 66 L 2.46x46 Structure Structure
TM2 67 A 2.47x47 Structure Structure
TM2 68 V 2.48x48 Structure Structure
TM2 69 F 2.49x49 Structure Structure
TM2 70 D 2.50x50 Structure Structure
TM2 71 L 2.51x51 Structure Structure
TM2 72 L 2.52x52 Structure Structure
TM2 73 L 2.53x53 Structure Structure
TM2 74 V 2.54x54 Structure Structure
TM2 75 L 2.55x55 Structure Structure
TM2 76 S 2.56x56 Structure Structure
TM2 77 L 2.57x57 Structure Structure
TM2 78 P 2.58x58 Structure Structure
TM2 79 F 2.59x59 Structure Structure
TM2 80 K 2.60x60 Structure Structure
TM2 81 M 2.61x61 Structure Structure
TM2 82 V 2.62x62 Structure Structure
TM2 83 L 2.63x63 Structure Structure
TM2 84 S 2.64x64 Structure Structure
TM2 85 Q 2.65x65 Structure Structure
TM2 86 V 2.66x66 Structure Structure
ECL1 87 Q - Structure Structure
ECL1 88 S - Structure Structure
ECL1 89 P - Structure Structure
TM3 90 F 3.21x21 Structure Structure
TM3 91 P 3.22x22 Structure Structure
TM3 92 S 3.23x23 Structure Structure
TM3 93 L 3.24x24 Structure Structure
TM3 94 C 3.25x25 Structure Structure
TM3 95 T 3.26x26 Structure Structure
TM3 96 L 3.27x27 Structure Structure
TM3 97 V 3.28x28 Structure Structure
TM3 98 E 3.29x29 Structure Structure
TM3 99 C 3.30x30 Structure Structure
TM3 100 L 3.31x31 Structure Structure
TM3 101 Y 3.32x32 Structure Structure
TM3 102 F 3.33x33 Structure Structure
TM3 103 V 3.34x34 Structure Structure
TM3 104 S 3.35x35 Structure Structure
TM3 105 M 3.36x36 Structure Structure
TM3 106 Y 3.37x37 Structure Structure
TM3 107 G 3.38x38 Structure Structure
TM3 108 S 3.39x39 Structure Structure
TM3 109 V 3.40x40 Structure Structure
TM3 110 F 3.41x41 Structure Structure
TM3 111 T 3.42x42 Structure Structure
TM3 112 I 3.43x43 Structure AF2
TM3 113 C 3.44x44 Structure Structure
TM3 114 F 3.45x45 Structure Structure
TM3 115 I 3.46x46 Structure Structure
TM3 116 S 3.47x47 Structure Structure
TM3 117 M 3.48x48 Structure Structure
TM3 118 D 3.49x49 Structure Structure
TM3 119 R 3.50x50 Structure Structure
TM3 120 F 3.51x51 Structure Structure
TM3 121 L 3.52x52 Structure Structure
TM3 122 A 3.53x53 Structure Structure
TM3 123 I 3.54x54 Structure Structure
TM3 124 R 3.55x55 Structure Structure
TM3 125 Y 3.56x56 Structure Structure
ICL2 126 P 34.50x50 Structure Structure
ICL2 127 L 34.51x51 Structure Structure
ICL2 128 L 34.52x52 Structure Structure
ICL2 129 V 34.53x53 Structure Structure
ICL2 130 S 34.54x54 Structure Structure
ICL2 131 H 34.55x55 Structure Structure
ICL2 132 L 34.56x56 Structure Structure
ICL2 133 R 34.57x57 Structure Structure
TM4 134 S 4.38x38 Structure Structure
TM4 135 P 4.39x39 Structure Structure
TM4 136 R 4.40x40 Structure Structure
TM4 137 K 4.41x41 Structure Structure
TM4 138 I 4.42x42 Structure Structure
TM4 139 F 4.43x43 Structure Structure
TM4 140 G 4.44x44 Structure Structure
TM4 141 I 4.45x45 Structure Structure
TM4 142 C 4.46x46 Structure Structure
TM4 143 C 4.47x47 Structure Structure
TM4 144 T 4.48x48 Structure Structure
TM4 145 I 4.49x49 Structure Structure
TM4 146 W 4.50x50 Structure Structure
TM4 147 V 4.51x51 Structure Structure
TM4 148 L 4.52x52 Structure Structure
TM4 149 V 4.53x53 Structure Structure
TM4 150 W 4.54x54 Structure Structure
TM4 151 T 4.55x55 Structure Structure
TM4 152 G 4.56x56 Structure Structure
TM4 153 S 4.57x57 Structure Structure
TM4 154 I 4.58x59 Structure Structure
TM4 155 P 4.59x60 Structure Structure
TM4 156 I 4.60x61 Structure Structure
TM4 157 Y 4.61x62 Structure Structure
TM4 158 S 4.62x63 Structure Structure
TM4 159 F 4.63x64 Structure Structure
TM4 160 H 4.64x65 Structure Structure
TM4 161 G 4.65x66 Structure Structure
TM4 162 K 4.66x67 Structure Structure
TM4 163 V 4.67x68 Structure Structure
TM4 164 E 4.68x69 Structure Structure
ECL2 165 K - Structure Structure
ECL2 166 Y - Structure Structure
ECL2 167 M - Structure Structure
ECL2 168 C 45.50x50 Structure Structure
ECL2 169 F 45.51x51 Structure Structure
ECL2 170 H 45.52x52 Structure Structure
ECL2 171 N - Structure Structure
ECL2 172 M - Structure Structure
ECL2 173 S - Structure Structure
ECL2 174 D - Structure Structure
ECL2 175 D - Structure Structure
ECL2 176 T - Structure Structure
ECL2 177 W - Structure Structure
TM5 178 S 5.35x36 Structure Structure
TM5 179 A 5.36x37 Structure Structure
TM5 180 K 5.37x38 Structure Structure
TM5 181 V 5.38x39 Structure Structure
TM5 182 F 5.39x40 Structure Structure
TM5 183 F 5.40x41 Structure Structure
TM5 184 P 5.41x42 Structure Structure
TM5 185 L 5.42x43 Structure Structure
TM5 186 E 5.43x44 Structure Structure
TM5 187 V 5.44x45 Structure Structure
TM5 188 F 5.45x46 Structure Structure
TM5 189 G 5.46x461 Structure Structure
TM5 190 F 5.47x47 Structure Structure
TM5 191 L 5.48x48 Structure Structure
TM5 192 L 5.49x49 Structure Structure
TM5 193 P 5.50x50 Structure Structure
TM5 194 M 5.51x51 Structure Structure
TM5 195 G 5.52x52 Structure Structure
TM5 196 I 5.53x53 Structure Structure
TM5 197 M 5.54x54 Structure Structure
TM5 198 G 5.55x55 Structure Structure
TM5 199 F 5.56x56 Structure Structure
TM5 200 C 5.57x57 Structure Structure
TM5 201 C 5.58x58 Structure Structure
TM5 202 S 5.59x59 Structure Structure
TM5 203 R 5.60x60 Structure Structure
TM5 204 S 5.61x61 Structure Structure
TM5 205 I 5.62x62 Structure Structure
TM5 206 H 5.63x63 Structure Structure
TM5 207 I 5.64x64 Structure Structure
TM5 208 L 5.65x65 Structure Structure
TM5 209 L 5.66x66 Structure Structure
TM5 210 G 5.67x67 Structure Structure
TM5 211 R 5.68x68 Structure Structure
TM5 212 R 5.69x69 Structure Structure
TM5 213 D 5.70x70 Structure Structure
TM5 214 H 5.71x71 Structure Structure
ICL3 215 T - Structure Structure
ICL3 216 Q - Structure Structure
ICL3 217 D - Structure Structure
ICL3 218 W - Structure Structure
ICL3 219 V - Structure Structure
ICL3 220 Q - Structure Structure
TM6 221 Q 6.30x30 Structure Structure
TM6 222 K 6.31x31 Structure Structure
TM6 223 A 6.32x32 Structure Structure
TM6 224 C 6.33x33 Structure Structure
TM6 225 I 6.34x34 Structure Structure
TM6 226 Y 6.35x35 Structure Structure
TM6 227 S 6.36x36 Structure Structure
TM6 228 I 6.37x37 Structure Structure
TM6 229 A 6.38x38 Structure Structure
TM6 230 A 6.39x39 Structure Structure
TM6 231 S 6.40x40 Structure Structure
TM6 232 L 6.41x41 Structure Structure
TM6 233 A 6.42x42 Structure Structure
TM6 234 V 6.43x43 Structure Structure
TM6 235 F 6.44x44 Structure Structure
TM6 236 V 6.45x45 Structure Structure
TM6 237 V 6.46x46 Structure Structure
TM6 238 S 6.47x47 Structure Structure
TM6 239 F 6.48x48 Structure Structure
TM6 240 L 6.49x49 Structure Structure
TM6 241 P 6.50x50 Structure Structure
TM6 242 V 6.51x51 Structure Structure
TM6 243 H 6.52x52 Structure Structure
TM6 244 L 6.53x53 Structure Structure
TM6 245 G 6.54x54 Structure Structure
TM6 246 F 6.55x55 Structure Structure
TM6 247 F 6.56x56 Structure Structure
TM6 248 L 6.57x57 Structure Structure
TM6 249 Q 6.58x58 Structure Structure
TM6 250 F 6.59x59 Structure Structure
TM6 251 L 6.60x60 Structure Structure
TM6 252 V 6.61x61 Structure Structure
TM6 253 R 6.62x62 Structure Structure
TM6 254 N 6.63x63 Structure Structure
TM6 255 S 6.64x64 Structure Structure
ECL3 256 F - Structure Structure
ECL3 257 I - Structure Structure
ECL3 258 V - Structure Structure
TM7 259 E 7.24x23 Structure Structure
TM7 260 C 7.25x24 Structure Structure
TM7 261 R 7.26x25 Structure Structure
TM7 262 A 7.27x26 Structure Structure
TM7 263 K 7.28x27 Structure Structure
TM7 264 Q 7.29x28 Structure Structure
TM7 265 S 7.30x29 Structure Structure
TM7 266 I 7.31x30 Structure Structure
TM7 267 S 7.32x31 Structure Structure
TM7 268 F 7.33x32 Structure Structure
TM7 269 F 7.34x33 Structure Structure
TM7 270 L 7.35x34 Structure Structure
TM7 271 Q 7.36x35 Structure Structure
TM7 272 L 7.37x36 Structure Structure
TM7 273 S 7.38x37 Structure Structure
TM7 274 M 7.39x38 Structure Structure
TM7 275 C 7.40x39 Structure Structure
TM7 276 F 7.41x40 Structure Structure
TM7 277 S 7.42x41 Structure Structure
TM7 278 N 7.43x42 Structure Structure
TM7 279 V 7.44x43 Structure Structure
TM7 280 N 7.45x45 Structure Structure
TM7 281 C 7.46x46 Structure Structure
TM7 282 C 7.47x47 Structure Structure
TM7 283 L 7.48x48 Structure Structure
TM7 284 D 7.49x49 Structure Structure
TM7 285 V 7.50x50 Structure Structure
TM7 286 F 7.51x51 Structure Structure
TM7 287 C 7.52x52 Structure Structure
TM7 288 Y 7.53x53 Structure Structure
TM7 289 Y 7.54x54 Structure Structure
TM7 290 F 7.55x55 Structure Structure
TM7 291 V 7.56x56 Structure Structure
H8 292 I 8.47x47 Structure Structure
H8 293 K 8.48x48 Structure Structure
H8 294 E 8.49x49 Structure Structure
H8 295 F 8.50x50 Structure Structure
H8 296 R 8.51x51 Structure Structure
H8 297 M 8.52x52 Structure Structure
H8 298 N 8.53x53 Structure Structure
H8 299 I 8.54x54 Structure Structure
H8 300 R 8.55x55 Structure Structure
H8 301 A 8.56x56 Structure Structure
H8 302 H 8.57x57 Structure Structure
H8 303 R 8.58x58 AF2 AF2
H8 304 P 8.59x59 AF2 AF2
H8 305 S 8.60x60 AF2 AF2
H8 306 R 8.61x61 AF2 AF2
C-term 307 V - AF2 AF2
C-term 308 Q - AF2 AF2
C-term 309 L - AF2 AF2
C-term 310 V - AF2 AF2
C-term 311 L - AF2 AF2
C-term 312 Q - AF2 AF2
C-term 313 D - AF2 AF2
C-term 314 T - AF2 AF2
C-term 315 T - AF2 AF2
C-term 316 I - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 208 5x65 G.H5 L 367 G.H5.16
Hydrophobic TM6 I 228 6x37 G.H5 L 376 G.H5.25
Van-der-waals TM6 I 228 6x37 G.H5 L 376 G.H5.25
Polar ICL2 S 130 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 S 130 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 I 207 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 R 133 34x57 G.H5 L 374 G.H5.23
Polar ICL2 R 133 34x57 G.H5 Q 373 G.H5.22
Polar TM6 Q 221 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 Q 221 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 A 223 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 A 223 6x32 G.H5 Q 377 G.H5.26
Hydrophobic H8 I 292 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 I 292 8x47 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 127 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM5 R 211 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 R 211 5x68 G.H5 L 367 G.H5.16
Hydrophobic ICL1 Y 56 - G.H5 K 372 G.H5.21
Van-der-waals ICL1 Y 56 - G.H5 K 372 G.H5.21
Polar TM6 C 224 6x33 G.H5 Q 377 G.H5.26
Hydrophobic TM6 C 224 6x33 G.H5 Q 377 G.H5.26
Hydrophobic TM2 M 63 2x43 G.H5 M 375 G.H5.24
Van-der-waals TM2 M 63 2x43 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 127 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL3 D 217 - G.h4s6 P 341 G.h4s6.20
Polar ICL3 Q 220 - G.h4s6 Q 339 G.h4s6.13
Van-der-waals ICL3 Q 220 - G.h4s6 Q 339 G.h4s6.13
Hydrophobic ICL1 Y 56 - G.H5 M 375 G.H5.24
Hydrophobic TM6 C 224 6x33 G.H5 L 371 G.H5.20
Hydrophobic ICL2 S 130 34x54 G.H5 N 370 G.H5.19
Polar TM6 S 227 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM6 S 227 6x36 G.H5 L 376 G.H5.25
Van-der-waals TM6 S 227 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 376 G.H5.25
Polar ICL3 Q 216 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 Q 216 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 T 215 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 T 215 - G.S6 Y 343 G.S6.02
Hydrophobic TM3 D 118 3x49 G.H5 L 374 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 L 374 G.H5.23
Hydrophobic H8 I 292 8x47 G.H5 Q 377 G.H5.26
Hydrophobic TM5 H 214 5x71 G.H5 R 360 G.H5.09
Hydrophobic TM3 A 122 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 L 374 G.H5.23
Polar TM3 A 122 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM1 F 48 1x60 G.H5 M 375 G.H5.24
Hydrophobic ICL2 P 126 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL1 D 55 - G.H5 Q 373 G.H5.22
Van-der-waals ICL1 D 55 - G.H5 Q 373 G.H5.22
Polar ICL2 P 126 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 N 370 G.H5.19
Ionic ICL3 D 217 - G.h4s6 R 334 G.h4s6.08
Polar ICL3 D 217 - G.h4s6 R 334 G.h4s6.08
Hydrophobic ICL3 D 217 - G.h4s6 R 334 G.h4s6.08
Van-der-waals ICL3 D 217 - G.h4s6 R 334 G.h4s6.08
Hydrophobic ICL3 T 215 - G.S6 L 342 G.S6.01
Van-der-waals ICL3 T 215 - G.S6 L 342 G.S6.01
Hydrophobic ICL2 P 126 34x50 G.H5 L 367 G.H5.16
Hydrophobic ICL2 H 131 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 H 131 34x55 G.hns1 R 47 G.hns1.03
Polar TM2 T 59 2x39 G.H5 Q 373 G.H5.22
Van-der-waals TM2 T 59 2x39 G.H5 Q 373 G.H5.22
Hydrophobic TM3 I 123 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 367 G.H5.16
Hydrophobic ICL2 P 126 34x50 G.H5 K 363 G.H5.12
Hydrophobic TM3 R 119 3x50 G.H5 L 376 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 371 G.H5.20
Polar ICL2 H 131 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 131 34x55 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 H 131 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 127 34x51 G.H5 F 359 G.H5.08
Hydrophobic TM2 S 60 2x40 G.H5 M 375 G.H5.24
Van-der-waals TM2 S 60 2x40 G.H5 M 375 G.H5.24
Hydrophobic TM6 Q 221 6x30 G.H5 L 371 G.H5.20
Van-der-waals TM6 Q 221 6x30 G.H5 L 371 G.H5.20
Ionic TM5 R 211 5x68 G.H5 D 364 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 R 211 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 364 G.H5.13
Ionic ICL3 D 217 - G.H4 R 331 G.H4.16
Polar ICL3 D 217 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 D 217 - G.H4 R 331 G.H4.16
Polar ICL3 D 217 - G.S6 L 342 G.S6.01
Polar TM6 C 224 6x33 G.H5 L 376 G.H5.25
Hydrophobic TM6 C 224 6x33 G.H5 L 376 G.H5.25
Van-der-waals TM6 C 224 6x33 G.H5 L 376 G.H5.25
Polar ICL3 T 215 - G.H5 D 364 G.H5.13
Ionic TM5 H 214 5x71 G.H5 D 364 G.H5.13
Polar TM5 H 214 5x71 G.H5 D 364 G.H5.13
Van-der-waals TM5 H 214 5x71 G.H5 D 364 G.H5.13
Hydrophobic TM2 T 59 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 T 59 2x39 G.H5 L 374 G.H5.23
Polar ICL3 Q 220 - G.H5 Q 377 G.H5.26
Hydrophobic ICL3 Q 220 - G.H5 Q 377 G.H5.26
Van-der-waals ICL3 Q 220 - G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 127 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 V 216 G.S3.01
Polar ICL3 Q 220 - G.h4s6 Q 337 G.h4s6.11
Van-der-waals ICL3 Q 220 - G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM3 R 119 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM2 Y 62 2x42 G.H5 L 374 G.H5.23
Hydrophobic TM2 T 59 2x39 G.H5 M 375 G.H5.24
Van-der-waals TM2 T 59 2x39 G.H5 M 375 G.H5.24
Polar TM6 Q 221 6x30 G.H5 Q 377 G.H5.26
Van-der-waals TM6 Q 221 6x30 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 S 130 34x54 G.H5 I 366 G.H5.15
Hydrophobic ICL3 T 215 - G.h4s6 P 341 G.h4s6.20
Polar H8 K 293 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 293 8x48 G.H5 Q 377 G.H5.26
Polar ICL3 Q 220 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 Q 220 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 Q 220 - G.H5 H 368 G.H5.17
Hydrophobic TM1 F 45 1x57 G.H5 M 375 G.H5.24
Van-der-waals TM1 F 45 1x57 G.H5 M 375 G.H5.24
Hydrophobic TM5 L 208 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 208 5x65 G.H5 L 371 G.H5.20
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